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公开(公告)号：EP0927304A4
公开(公告)日：1999-12-15
申请号：EP97944374
申请日：1997-09-19
Applicant: ARNOLD LEE
Inventor： ARNOLD LEE
CPC classification number: F03D5/00 , F03B17/00 , F03B17/06 , F03D5/06 , F03D9/12 , F05B2240/124 , Y02E10/28 , Y02E10/38 , Y02E10/70 , Y02E10/72 , Y02E60/16
Abstract: Method and apparatus for converting the kinetic energy of a moving fluid stream into useful work by using a cascade of thin aero of hydro foils (2) positioned therein. The foils may be provided with at least two degrees of freedom and adjacent foils move out of phase. The foils are subjected to fluid induced oscillations known as flutter. Barriers (3, 43) may be positioned downstream, above, or at the sides of the apparatus for increasing efficiency. A system of fly wheels (17, 18) to increase inertia of the foils may be used with the hydrofoils. A cascade of aero of hydro foils may be mechanically oscillated.
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公开(公告)号：DE69729106D1
公开(公告)日：2004-06-17
申请号：DE69729106
申请日：1997-09-19
Applicant: ARNOLD LEE
Inventor： ARNOLD LEE
Abstract: Method and apparatus for converting the kinetic energy of a moving fluid stream into useful work by using a cascade of thin aero or hydro foils positioned therein. The foils may be provided with at least two degrees of freedom and adjacent foils move out of phase. The foils are subjected to fluid induced oscillations known as flutter. Barriers (3, 43) may be positioned upstream, above, or at sides of the apparatus for increasing efficiency by increasing the fluid velocity. A system of flywheels (17, 18) are used to increase inertia of the foils and are particularly useful with hydrofoils. A cascade of aero or hydro foils may be mechanically oscillated to transfer energy to a fluid.
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公开(公告)号：CA2266632A1
公开(公告)日：1998-03-26
申请号：CA2266632
申请日：1997-09-19
Applicant: ARNOLD LEE
Inventor： ARNOLD LEE
Abstract: Method and apparatus for converting the kinetic energy of a moving fluid stream into useful work by using a cascade of thin aero of hydro foils (2) positioned therein. The foils may be provided with at least two degrees of freedom and adjacent foils move out of phase. The foils are subjected to fluid induced oscillations known as flutter. Barriers (3, 43) may be positioned downstream, above, or at the sides of the apparatus for increasing efficiency. A system of fly wheels (17, 18) to increase inertia of the foils may be used with the hydrofoils. A cascade of aero of hydro foils may be mechanically oscillated.
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公开(公告)号：WO2008137834A3
公开(公告)日：2009-02-26
申请号：PCT/US2008062636
申请日：2008-05-05
Applicant: OSI PHARM INC , SGX PHARMACEUTICALS INC , FOREMAN KENNETH WILLIAM , PARK FRANCES E , ARNOLD LEE
Inventor： FOREMAN KENNETH WILLIAM , PARK FRANCES E , ARNOLD LEE
CPC classification number: C12N9/1007 , C07K2299/00 , G01N2500/04
Abstract: The invention relates to SMYD3 methyltransferase (SMYD3), SMYD3 binding pockets or SMYD3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to SMYD3 methyltransferase protein, complexes of SMYD3 methyltransferase protein, homologues thereof, or SMYD3-like protein or protein complexes.
Abstract translation: 本发明涉及SMYD3甲基转移酶（SMYD3），SMYD3结合口袋或SMYD3样结合口袋。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标来筛选和设计结合SMYD3甲基转移酶蛋白质的化合物，SMYD3甲基转移酶蛋白质的复合物，其同源物或SMYD3样蛋白质或蛋白质复合物的方法。
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公开(公告)号：WO0109121A3
公开(公告)日：2002-05-02
申请号：PCT/US0020628
申请日：2000-07-28
Applicant: BASF AG , MOSET MARINA M , BERLANGA JOSE MARIA CASTELLANO , FERNANDEZ ISABEL F , CALDERWOOD DAVID J , RAFFERTY PAUL , ARNOLD LEE
Inventor： MOSET MARINA M , BERLANGA JOSE MARIA CASTELLANO , FERNANDEZ ISABEL F , CALDERWOOD DAVID J , RAFFERTY PAUL , ARNOLD LEE
IPC: A61K31/4152 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P1/00 , A61P1/04 , A61P1/14 , A61P1/16 , A61P3/10 , A61P3/12 , A61P5/14 , A61P5/16 , A61P7/00 , A61P7/10 , A61P9/10 , A61P9/14 , A61P11/00 , A61P15/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P37/08 , A61P43/00 , C07D231/20 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
CPC classification number: C07D401/06 , C07D231/20 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Chemical compounds having structural formula (I) and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyperproliferative disorders.
Abstract translation: 具有结构式（I）的化合物及其生理上可接受的盐是丝氨酸/苏氨酸和酪氨酸激酶活性的抑制剂。 几种酪氨酸激酶（其活性被这些化合物抑制）参与血管发生过程。 因此，这些化合物可以改善其中血管生成或内皮细胞过度增殖是一个因素的疾病状态。 这些化合物可用于治疗癌症和过度增殖性疾病。
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Patent Agency Ranking
公开(公告)号：DE69729106T2
公开(公告)日：2005-05-12
申请号：DE69729106
申请日：1997-09-19
Applicant: ARNOLD LEE
Inventor： ARNOLD LEE
Abstract: Method and apparatus for converting the kinetic energy of a moving fluid stream into useful work by using a cascade of thin aero or hydro foils positioned therein. The foils may be provided with at least two degrees of freedom and adjacent foils move out of phase. The foils are subjected to fluid induced oscillations known as flutter. Barriers (3, 43) may be positioned upstream, above, or at sides of the apparatus for increasing efficiency by increasing the fluid velocity. A system of flywheels (17, 18) are used to increase inertia of the foils and are particularly useful with hydrofoils. A cascade of aero or hydro foils may be mechanically oscillated to transfer energy to a fluid.
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公开(公告)号：AT266811T
公开(公告)日：2004-05-15
申请号：AT97944374
申请日：1997-09-19
Applicant: ARNOLD LEE
Inventor： ARNOLD LEE
Abstract: Method and apparatus for converting the kinetic energy of a moving fluid stream into useful work by using a cascade of thin aero or hydro foils positioned therein. The foils may be provided with at least two degrees of freedom and adjacent foils move out of phase. The foils are subjected to fluid induced oscillations known as flutter. Barriers (3, 43) may be positioned upstream, above, or at sides of the apparatus for increasing efficiency by increasing the fluid velocity. A system of flywheels (17, 18) are used to increase inertia of the foils and are particularly useful with hydrofoils. A cascade of aero or hydro foils may be mechanically oscillated to transfer energy to a fluid.
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公开(公告)号：CA2266632C
公开(公告)日：2004-03-09
申请号：CA2266632
申请日：1997-09-19
Applicant: ARNOLD LEE
Inventor： ARNOLD LEE
Abstract: Method and apparatus for converting the kinetic energy of a moving fluid stream into useful work by using a cascade of thin aero of hydro foils (2) positioned therein. The foils may be provided with at least two degrees of freedom and adjacent foils move out of phase. The foils are subjected to fluid induced oscillations known as flutter. Barriers (3, 43) may be positioned downstream, above, or at the sides of the apparatus for increasing efficiency. A system of fly wheels (17, 18) to increase inertia of the foils may be used with the hydrofoils. A cascade of aero of hydro foils may be mechanically oscillated.
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公开(公告)号：AU4588497A
公开(公告)日：1998-04-14
申请号：AU4588497
申请日：1997-09-19
Applicant: ARNOLD LEE
Inventor： ARNOLD LEE
Abstract: Method and apparatus for converting the kinetic energy of a moving fluid stream into useful work by using a cascade of thin aero or hydro foils positioned therein. The foils may be provided with at least two degrees of freedom and adjacent foils move out of phase. The foils are subjected to fluid induced oscillations known as flutter. Barriers (3, 43) may be positioned upstream, above, or at sides of the apparatus for increasing efficiency by increasing the fluid velocity. A system of flywheels (17, 18) are used to increase inertia of the foils and are particularly useful with hydrofoils. A cascade of aero or hydro foils may be mechanically oscillated to transfer energy to a fluid.
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公开(公告)号：CA1132436A
公开(公告)日：1982-09-28
申请号：CA341760
申请日：1979-12-12
Applicant: ARNOLD LEE
Inventor： ARNOLD LEE
IPC: F03D5/06
Abstract: There is disclosed a method and apparatus for converting the kinetic energy of a moving fluid stream into useful work by means of a cascade of thin airfoils positioned therein. In one embodiment, the airfoils are provided with at least two degrees of freedom and adjacent airfoils are movable out of phase. The airfoils are subjected to the aerodynamically induced oscillations caused by the aeroelastic phenomenon known as flutter and the oscillatory movement is then harnessed to do useful work. In an alternate embodiment, a cascade of airfoils is mechanically oscillated within a moving fluid stream to increase the propulsion of the fluid. Where the fluid is a liquid, the cascade includes a plurality of hydrofoils.
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