Patent search ap:("ARRAY BIOPHARMA INC") AND inv:"NEWHOUSE BRAD" Page 1

1.

发明申请
RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
Title translation: RAF抑制剂化合物及其使用方法

公开(公告)号：WO2009111278A2

公开(公告)日：2009-09-11

申请号：PCT/US2009035380

申请日：2009-02-27

Applicant: ARRAY BIOPHARMA INC , GENENTECH INC , AHRENDT KATERI A , BUCKMELTER ALEXANDRE J , GRINA JONAS , HANSEN JOSHUA D , LAIRD ELLEN R , MORENO DAVID , NEWHOUSE BRAD , REN LI , WENGLOWSKY STEVEN MARK , FENG BAINIAN , GUNZNER JANET , MALESKY KIM , MATHIEU SIMON , RUDOLPH JOACHIM , WEN ZHAOYANG , YOUNG WENDY B

Inventor： AHRENDT KATERI A , BUCKMELTER ALEXANDRE J , GRINA JONAS , HANSEN JOSHUA D , LAIRD ELLEN R , MORENO DAVID , NEWHOUSE BRAD , REN LI , WENGLOWSKY STEVEN MARK , FENG BAINIAN , GUNZNER JANET , MALESKY KIM , MATHIEU SIMON , RUDOLPH JOACHIM , WEN ZHAOYANG , YOUNG WENDY B

IPC: A61K31/4745

CPC classification number: C07D471/04 , C07C311/08

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式I化合物可用于抑制Raf激酶。公开了使用式I化合物和立体异构体，互变异构体，前药和其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

2.

发明申请
IMDIZO [4. 5-B] PYRIDINE DERIVATIVES USED AS RAF INHIBITORS 审中-公开
Title translation: IMDIZO [4。 5-B]吡啶衍生物用作RAF抑制剂

公开(公告)号：WO2009111277A1

公开(公告)日：2009-09-11

申请号：PCT/US2009035379

申请日：2009-02-27

Applicant: ARRAY BIOPHARMA INC , GENENTECH INC , AHRENDT KATERI A , BUCKMELTER ALEXANDRE J , GRINA JONAS , HANSEN JOSHUA D , LAIRD ELLEN R , NEWHOUSE BRAD , REN LI , WENGLOWSKY STEVEN M , FENG BAINIAN , MALESKY KIM , MATHIEU SIMON , RUDOLPH JOACHIM , WEN ZHAOYANG , YOUNG WENDY B , MORENO DAVID A

Inventor： AHRENDT KATERI A , BUCKMELTER ALEXANDRE J , GRINA JONAS , HANSEN JOSHUA D , LAIRD ELLEN R , NEWHOUSE BRAD , REN LI , WENGLOWSKY STEVEN M , FENG BAINIAN , MALESKY KIM , MATHIEU SIMON , RUDOLPH JOACHIM , WEN ZHAOYANG , YOUNG WENDY B , MORENO DAVID A

IPC: C07D471/04 , A61K31/437 , A61P13/12 , A61P35/00 , C07C311/08

CPC classification number: C07D471/04 , C07C311/48

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式I化合物可用于抑制Raf激酶。公开了使用式I化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

3.

发明申请
SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS 审中-公开
Title translation: 作为类似感受体调节剂的替代苯扎林

公开(公告)号：WO2011022508A2

公开(公告)日：2011-02-24

申请号：PCT/US2010045934

申请日：2010-08-18

Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC , HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON

Inventor： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON

IPC: C07D401/14 , A61K31/4025 , A61K31/454 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D403/10

CPC classification number: A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。

4.

发明申请
RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
Title translation: RAF抑制剂化合物及其使用方法

公开(公告)号：WO2006125101A2

公开(公告)日：2006-11-23

申请号：PCT/US2006019280

申请日：2006-05-18

Applicant: ARRAY BIOPHARMA INC , LAIRD ELLEN , TOPALOV GEORGE , LYSSIKATOS JOSEPH P , WELCH MIKE , GRINA JONAS , HANSEN JOSH , NEWHOUSE BRAD

Inventor： LAIRD ELLEN , TOPALOV GEORGE , LYSSIKATOS JOSEPH P , WELCH MIKE , GRINA JONAS , HANSEN JOSH , NEWHOUSE BRAD

CPC classification number: C07D487/04

Abstract: Compounds of Formula (I) are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula (I), and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式（I）的化合物可用于抑制Raf激酶和用于治疗由此介导的病症。公开了使用式（I）化合物及其立体异构体，互变异构体，溶剂合物及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理学病症中的这种病症的方法。

5.

发明申请
RAF INHIBITOR COMPOUNDS AND METHODS 审中-公开
Title translation: RAF抑制剂化合物和方法

公开(公告)号：WO2006084015A2

公开(公告)日：2006-08-10

申请号：PCT/US2006003654

申请日：2006-02-02

Applicant: GENENTECH INC , ARRAY BIOPHARMA INC , LAIRD ELLEN , LYSSIKATOS JOSEPH P , WELCH MIKE , GRINA JONAS , HANSEN JOSH , NEWHOUSE BRAD , OLIVERO ALAN , TOPOLAV GEORGE

Inventor： LAIRD ELLEN , LYSSIKATOS JOSEPH P , WELCH MIKE , GRINA JONAS , HANSEN JOSH , NEWHOUSE BRAD , OLIVERO ALAN , TOPOLAV GEORGE

IPC: C07D401/04 , A61K31/415 , A61P3/10 , A61P9/00 , A61P17/06 , A61P25/00 , A61P35/00 , A61P37/00 , C07D401/14 , C07D471/04

CPC classification number: C07D405/14 , C07D401/04 , C07D401/14 , C07D403/02 , C07D487/04

Abstract: Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式Ia和Ib的吡唑基化合物可用于抑制Raf激酶并用于治疗由其介导的病症。公开了使用吡唑基化合物体外，原位和体内诊断，预防或治疗哺乳动物细胞中的此类病症或相关病理学病症的方法。

6.

发明公开
SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS 有权

公开(公告)号：EP2467377A4

公开(公告)日：2013-01-02

申请号：EP10810563

申请日：2010-08-18

Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC

Inventor： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON

IPC: C07D401/14 , A61K31/4025 , A61K31/454 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D403/10

CPC classification number: A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10

7.

发明专利
SERINE/THREONINE KINASE INHIBITORS 未知

公开(公告)号：CA2934709C

公开(公告)日：2022-08-30

申请号：CA2934709

申请日：2014-12-29

Applicant: ARRAY BIOPHARMA INC , GENENTECH INC

Inventor： BLAKE JAMES F , COOK ADAM , GAUDINO JOHN , GUNAWARDANA INDRANI W , HICKEN ERIK JAMES , HUNT KEVIN W , LYON MICHAEL , METCALF ANDREW T , MOHR PETER J , MORENO DAVID A , NEWHOUSE BRAD , REN LI , SCHWARZ JACOB , CHEN HUIFEN , GAZZARD LEWIS , SCHMIDT JANE , DO STEVE

IPC: C07D487/04 , A61K31/444 , A61K31/506 , A61P29/00

Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are selective inhibitors of ERK and are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro , in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.