公开(公告)号：WO2009042435A8

公开(公告)日：2009-10-08

申请号：PCT/US2008076401

申请日：2008-09-15

Applicant: ARRAY BIOPHARMA INC ,  AICHER THOMAS DANIEL ,  BOYD STEVEN ARMEN ,  CHICARELLI MARK JOSEPH ,  CONDROSKI KEVIN RONALD ,  FELL JAY BRADFORD ,  FISCHER JOHN P ,  GUNAWARDANA INDRANI W ,  HINKLIN RONALD JAY ,  SINGH AJAY ,  TURNER TIMOTHY M ,  WALLACE ELI M

Inventor： AICHER THOMAS DANIEL ,  BOYD STEVEN ARMEN ,  CHICARELLI MARK JOSEPH ,  CONDROSKI KEVIN RONALD ,  FELL JAY BRADFORD ,  FISCHER JOHN P ,  GUNAWARDANA INDRANI W ,  HINKLIN RONALD JAY ,  SINGH AJAY ,  TURNER TIMOTHY M ,  WALLACE ELI M

IPC: C07D417/12 ,  A61K31/433 ,  A61P3/10 ,  C07D417/14

CPC classification number: C07D401/14 ,  C07D213/75 ,  C07D401/12 ,  C07D417/12 ,  C07D417/14

Abstract: Provided are compounds of Formula (I): wherein R2, R3, R13, L and D2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.

Abstract translation: 提供了式（I）的化合物：其中R 2，R 3，R 13，L和D 2如说明书中所定义，其可用于治疗和/或预防由葡萄糖激酶活性水平不足所介导的疾病或病症， 通过激活包括但不限于糖尿病，葡萄糖耐量降低，IFG（空腹葡萄糖受损）和IFG（空腹血糖受损）以及其他疾病和病症（例如本文讨论的那些）的葡萄糖激酶来治疗。

公开(公告)号：MY180558A

公开(公告)日：2020-12-02

申请号：MYPI2010001186

申请日：2008-09-15

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYD STEVEN ARMEN ,  AICHER THOMAS DANIEL ,  CONDROSKI KEVIN RONALD ,  HINKLIN RONALD JAY ,  CHICARELLI MARK JOSEPH ,  FELL JAY BRADFORD ,  FISCHER JOHN P ,  GUNAWARDANA INDRANI W ,  SINGH AJAY ,  TURNER TIMOTHY M ,  WALLACE ELI M

Abstract: PROVIDED ARE COMPOUNDS OF FORMULA I WHEREIN R2, R3, R13, L AND D2 ARE AS DEFINED IN THE SPECIFICATION, WHICH ARE USEFUL IN THE TREATMENT AND/OR PREVENTION OF DISEASES OR DISORDERS MEDIATED BY DEFICIENT LEVELS OF GLUCOKINASE ACTIVITY OR WHICH CAN BE TREATED BY ACTIVATING GLUCOKINASE INCLUDING, BUT NOT LIMITED TO, DIABETES MELLITUS, IMPAIRED GLUCOSE TOLERANCE, IFG (IMPAIRED FASTING GLUCOSE) AND IFG (IMPAIRED FASTING GLYCEMIA), AS WELL AS OTHER DISEASES AND DISORDERS SUCH AS THOSE DISCUSSED HEREIN.

公开(公告)号：SG188985A1

公开(公告)日：2013-05-31

申请号：SG2013018551

申请日：2011-09-15

Applicant: ARRAY BIOPHARMA INC

Inventor： AICHER THOMAS DANIEL ,  BENCSIK JOSEF R ,  BOYD STEVEN ARMEN ,  CONDROSKI KEVIN RONALD ,  FELL JAY BRADFORD ,  FISCHER JOHN P ,  HINKLIN RONALD JAY ,  PRATT SCOTT ALAN ,  SINGH AJAY ,  TURNER TIMOTHY M

Abstract: Compounds of Formula (I) and pharmaceutically acceptable salts thereof in which X1, X2, L, R3, R4, R5, R7 and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.

公开(公告)号：SI2209778T1

公开(公告)日：2012-12-31

申请号：SI200830746

申请日：2008-09-15

Applicant: ARRAY BIOPHARMA INC

Inventor： AICHER THOMAS DANIEL ,  BOYD STEVEN ARMEN ,  CHICARELLI MARK JOSEPH ,  CONDROSKI KEVIN RONALD ,  FELL JAY BRADFORD ,  FISCHER JOHN P ,  GUNAWARDANA INDRANI W ,  HINKLIN RONALD JAY ,  SINGH AJAY ,  TURNER TIMOTHY M ,  WALLACE ELI M

IPC: C07D417/00 ,  A61K31/00 ,  A61P3/00

公开(公告)号：ZA201102350B

公开(公告)日：2012-09-26

申请号：ZA201102350

申请日：2011-03-29

Applicant: ARRAY BIOPHARMA INC

Inventor： AICHER THOMAS DANIEL ,  BOYD STEVEN ARMEN ,  CHICARELLI MARK JOSEPH ,  CONDROSKI KEVIN RONALD ,  FELL JAY BRADFORD ,  FISCHER JOHN P ,  GUNAWARDANA INDRANI W ,  HINKLIN RONALD JAY ,  SINGH AJAY ,  TURNER TIMOTHY M ,  WALLACE ELI M

IPC: A61P20060101 ,  A61K20060101 ,  C07D20060101

Abstract: Provided are compounds of Formula I wherein R 2 , R 3 , R 13 , L and D 2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.

公开(公告)号：ZA201002206B

公开(公告)日：2011-06-29

申请号：ZA201002206

申请日：2010-03-29

Applicant: ARRAY BIOPHARMA INC

Inventor： TURNER TIMOTHY M ,  GUNAWARDANA INDRANI W ,  FISCHER JOHN P ,  FELL JAY BRADFORD ,  CONDROSKI KEVIN RONALD ,  CHICARELLI MARK JOSEPH ,  AICHER THOMAS DANIEL ,  BOYD STEVEN ARMEN ,  SINGH AJAY ,  HINKLIN RONALD JAY ,  WALLACE ELI M

Abstract: Provided are compounds of Formula I wherein R 2 , R 3 , R 13 , L and D 2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.

公开(公告)号：BR112013006344A2

公开(公告)日：2016-06-21

申请号：BR112013006344

申请日：2011-09-15

Applicant: ARRAY BIOPHARMA INC

Inventor： SINGH AJAY ,  FELL JAY BRADFORD ,  FISCHER JOHN P ,  BENCSIK JOSEF R ,  CONDROSKI KEVIN RONALD ,  HINKLIN RONALD JAY ,  PRATT SCOTT ALAN ,  BOYD STEVEN ARMEN ,  AICHER THOMAS DANIEL ,  TURNER TIMOTHY M

IPC: C07D413/14 ,  A61K31/4468 ,  A61K31/454 ,  A61P3/04

Abstract: lactamas substituídas por piperdinila como moduladores de gpr119. a presente invenção refere-se a compostos de fórmula (i) e a sais farmaceuticamente aceitáveis dos mesmos, nos quais x^ 1^, x^ 2^, l, r^ 3^, r^ 4, r^ 5^, r^ 7^ e n têm os significados dados no relatório descritivo, que são moduladores de gpr119 e são úteis no tratamento ou na prevenção de doenças, tais como, mas não limitadas a, diabetes do tipo 2, complicações diabéticas, sintomas de diabetes, metabólica, obesidade, dislipidemia e condições relacionadas.

公开(公告)号：CR20150131A

公开(公告)日：2015-04-30

申请号：CR20150131

申请日：2015-03-12

Applicant: ARRAY BIOPHARMA INC

Inventor： AICHER THOMAS DANIEL ,  BOYD STEVEN ARMEN ,  CHICARELLI MARK JOSEPH ,  CONDROSKI KEVIN RONALD ,  FELL JAY BRADFORD ,  FISCHER JOHN P ,  GUNAWARDANA INDRANI W ,  HINKLIN RONALD JAY ,  SINGH AJAY ,  TURNER TIMOTHY M ,  WALLACE ELI M

IPC: C07D417/12 ,  A61K31/433 ,  A61P3/10 ,  C07D417/14

Abstract: Se proporcionan compuestos de la Fórmula I, en donde R2, R3, R13, L y D2 son lo definido en la memoria descriptiva, que son útiles en el tratamiento y/o en la prevención de enfermedades o trastornos mediados por niveles deficientes de actividad de glucocinasa o que se pueden tratar activando glucocinasa que incluyen, en forma no taxativa, diabetes mellitus, deterioro de tolerancia de la glucosa, IFG (deterioro de glucosa en ayunas) e IFG (deterioro de glucemia en ayunas), así como otras enfermedades y trastornos tales como aquellos discutidos en la presente.

公开(公告)号：UY33614A

公开(公告)日：2013-04-05

申请号：UY33614

申请日：2011-09-16

Applicant: ARRAY BIOPHARMA INC

Inventor： AICHER THOMAS DANIEL ,  BENCSIK JOSEF ROLAND ,  FISCHER JOHN P ,  PRATT SCOTT ALAN ,  TURNER TIMOTHY M ,  BOYD STEVEN ARMEN ,  CONDROSKI KEVIN RONALD ,  FELL JAY BRADFORD ,  HINKLIN RONALD JAY ,  AJAY SINGH

IPC: A61K31/454 ,  A61K31/4545 ,  A61P3/04 ,  A61P3/10 ,  C07D413/14

Abstract: Compuestos de Fórmula I y sales farmacéuticamente aceptables de los mismos donde X1, X2, L, R3, R4, R5, R' y n tienen los significados dados en la memoria descriptiva, son moduladores de GPR119 y son útiles en el tratamiento o prevención de enfermedades tales como pero sin limitación a, diabetes tipo 2, complicaciones diabéticas, síntomas de diabetes, síndrome metabólico, obesidad, dislipidemia y afecciones relacionadas.

公开(公告)号：AU2011256455A1

公开(公告)日：2013-01-10

申请号：AU2011256455

申请日：2011-05-13

Applicant: ARRAY BIOPHARMA INC

Inventor： AICHER THOMAS DANIEL ,  BENCSIK JOSEF ROLAND ,  CONDROSKI KEVIN RONALD ,  FELL JAY BRADFORD ,  FISCHER JOHN P ,  HINKLIN RONALD JAY ,  PRATT SCOTT ALAN ,  SINGH AJAY ,  TURNER TIMOTHY M ,  BOYD STEVEN ARMEN

IPC: C07D401/14 ,  A61K31/4545 ,  A61P3/10

Abstract: Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which X