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    Apparatus and method for purifying/separating particle
    1.
    发明专利
    Apparatus and method for purifying/separating particle 有权
    用于净化/分离颗粒的装置和方法

    公开(公告)号：JP2012020149A

    公开(公告)日：2012-02-02

    申请号：JP2011200448

    申请日：2011-09-14

    Applicant: Arryx Inc ,  アリックス インコーポレイテッド

    Inventor： ANDERSON AMY ,  GRUBER LEWIS ,  MUETH DANIEL ,  PLEWA JOSEPH ,  SHIREMAN JESSICA ,  ROSENBAUM NEIL HARRIS

    IPC: A61M1/02 ,  A61M1/36 ,  A61M1/38 ,  C12M3/00 ,  C12N5/076 ,  C12N5/078 ,  G01N33/483 ,  G21K1/00

    CPC classification number: A61M1/36 ,  A61M1/38 ,  B03C1/28 ,  B03C5/005 ,  B03C2201/02 ,  B03C2201/18 ,  G01N30/0005 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2001/085 ,  H05H3/04

    Abstract: PROBLEM TO BE SOLVED: To provide a method, apparatus, and system for separating blood and other types of cellular components.SOLUTION: One of the exemplary methods includes: providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps 200 may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

    Abstract translation: 要解决的问题：提供用于分离血液和其他类型的细胞组分的方法，装置和系统。 解决方案：示例性方法之一包括：提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中，同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。 然后，具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。 全息光学捕集器200还可以与各种流动结合使用，以将所选择的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。 版权所有（C）2012，JPO＆INPIT

    METHOD AND APPARATUS FOR SORTING CELLS
    3.
    发明专利
    METHOD AND APPARATUS FOR SORTING CELLS 未知

    公开(公告)号：HK1112288A1

    公开(公告)日：2008-08-29

    申请号：HK08107559

    申请日：2008-07-09

    Applicant: ARRYX INC

    Inventor： MUETH DANIEL ,  ANDERSON AMY L ,  KNUTSON CHRISTOPHER R ,  PLEWA JOSEPH

    IPC: G01N20060101

    Abstract: Apparatus for sorting and orienting sperm cells has a pair or walls (314, 316) in confronting relationship forming a flow chamber (312) having an inlet, a downstream outlet, and intermediate detector region (338). The inlet receives first and second spaced apart streams of input fluid and a third stream of sample fluid (328) containing the cells (330) to be sorted. The first and second streams have respective flow rates relative to the third stream, such that the third stream is constricted forming a relatively narrow sample stream, so that the cells (330) are oriented parallel to the walls (314, 316). A detector (340) detects desired cells (330) and a sorter (356) downstream of the detector (340) sorts the desired cells (330) from the stream.

    5.
    发明专利
    未知

    公开(公告)号：BRPI0607095A2

    公开(公告)日：2009-08-04

    申请号：BRPI0607095

    申请日：2006-02-01

    Applicant: ARRYX INC

    Inventor： MUETH DANIEL ,  ANDERSON AMY L ,  KNUTSON CHRISTOPHER R ,  PLEWA JOSEPH

    IPC: G01N21/01 ,  G01N33/00

    Abstract: Apparatus for sorting and orienting sperm cells has a pair or walls (314, 316) in confronting relationship forming a flow chamber (312) having an inlet, a downstream outlet, and intermediate detector region (338). The inlet receives first and second spaced apart streams of input fluid and a third stream of sample fluid (328) containing the cells (330) to be sorted. The first and second streams have respective flow rates relative to the third stream, such that the third stream is constricted forming a relatively narrow sample stream, so that the cells (330) are oriented parallel to the walls (314, 316). A detector (340) detects desired cells (330) and a sorter (356) downstream of the detector (340) sorts the desired cells (330) from the stream.

    SYSTEM AND METHOD FOR MANIPULATING AND PROCESSING MATERIALS USING HOLOGRAPHIC OPTICAL TRAPPING
    6.
    发明申请
    SYSTEM AND METHOD FOR MANIPULATING AND PROCESSING MATERIALS USING HOLOGRAPHIC OPTICAL TRAPPING 审中-公开
    使用全息光学跟踪处理和处理材料的系统和方法

    公开(公告)号：WO2005089437A3

    公开(公告)日：2006-10-26

    申请号：PCT/US2005008934

    申请日：2005-03-17

    Applicant: ARRYX INC ,  PLEWA JOSEPH ,  TANNER EVAN ,  MUETH DAN ,  GRUBER LEWIS ,  BRADLEY KENNETH

    Inventor： PLEWA JOSEPH ,  TANNER EVAN ,  MUETH DAN ,  GRUBER LEWIS ,  BRADLEY KENNETH

    IPC: H01S1/00 ,  G02B5/18 ,  G02B26/00 ,  G02B27/44 ,  G21K1/00 ,  H01S3/00 ,  H05H3/02 ,  H05H3/04

    CPC classification number: B82Y20/00 ,  B82Y10/00 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2225/32

    Abstract: A method and apparatus for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic; the trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.

    Abstract translation: 一种用于通过用衍射光学元件（DOE）调制激光束而形成的光阱来操纵具有一个或多个特性的微粒（微，纳米和微微）的方法和装置。 选择材料的至少一种特性; 并且产生具有与材料的至少一个所选特征对应的选定波长的激光束。 根据材料的至少一个所选特征计算DOE的值。 光束和DOE被调制以产生具有对应于至少一个所选特征的性质的全息光阱; 陷阱聚焦到光束焦点或选定的光斑尺寸; 并且束聚焦位于颗粒位置附近以将颗粒捕获在其中。

    METHOD AND APPARATUS FOR SORTING CELLS
    7.
    发明申请
    METHOD AND APPARATUS FOR SORTING CELLS 审中-公开
    分离细胞的方法和装置

    公开(公告)号：WO2006083907A3

    公开(公告)日：2006-12-21

    申请号：PCT/US2006003462

    申请日：2006-02-01

    Applicant: ARRYX INC ,  MUETH DANIEL ,  ANDERSON AMY L ,  KNUTSON CHRISTOPHER R ,  PLEWA JOSEPH

    Inventor： MUETH DANIEL ,  ANDERSON AMY L ,  KNUTSON CHRISTOPHER R ,  PLEWA JOSEPH

    IPC: G01N21/01 ,  G01N33/00

    CPC classification number: G01N21/6428 ,  C12M47/04 ,  G01N15/1404 ,  G01N15/1459 ,  G01N2015/1409 ,  G01N2015/1411 ,  G01N2015/149

    Abstract: Apparatus for sorting and orienting sperm cells has a pair or walls (314, 316) in confronting relationship forming a flow chamber (312) having inlet, a downstream outlet, and intermediate detector region (338). The inlet receives first and second spaced apart streams of input fluid and a third stream of sample fluid (328) containing the cells (330) to be sorted. The first and second streams have respective flow rates relative to third stream, such that the third stream is constricted forming a relatively narrow sample stream, so that the cells (330) are oriented parallel to the walls (314, 316). A detector (340) detect desired cells (330) and a sorter (356) downstream of the detector (340) for sorting the desired cells (330) from the stream.

    Abstract translation: 用于分选和定向精子细胞的装置具有面对关系的一对或多个壁（314,316），形成具有入口，下游出口和中间检测器区域（338）的流动室（312）。 入口接收第一和第二间隔开的输入流体流和包含要分选的单元（330）的第三流样品流体（328）。 第一和第二流具有相对于第三流的相应流速，使得第三流收缩形成相对窄的样品流，使得单元（330）平行于壁（314,316）定向。 检测器（340）检测检测器（340）下游的所需单元（330）和分选器（​​356），用于从流中分选所需单元（330）。

    APPARATUS FOR OPTICALLY-BASED SORTING WITHIN LIQUID CORE WAVEGUIDES
    10.
    发明申请
    APPARATUS FOR OPTICALLY-BASED SORTING WITHIN LIQUID CORE WAVEGUIDES 审中-公开
    用于在液体核心波形中进行光学分离的装置

    公开(公告)号：WO2006110749A3

    公开(公告)日：2007-12-13

    申请号：PCT/US2006013477

    申请日：2006-04-10

    Applicant: ARRYX INC ,  MUETH DANIEL ,  TANNER EVAN ,  PLEWA JOSEPH ,  AKCAKIR OSMAN

    Inventor： MUETH DANIEL ,  TANNER EVAN ,  PLEWA JOSEPH ,  AKCAKIR OSMAN

    IPC: G02B6/032 ,  G02B6/10 ,  H01L21/00

    CPC classification number: G01N21/05 ,  G01N21/0303 ,  G01N2015/149 ,  G01N2021/0346 ,  G02B6/032

    Abstract: The present invention is related to an apparatus for the sorting of particles in a fluid medium flowing within a liquid-core waveguide, by combining customized light intensity patterns formed inside the waveguide, and diluting the suspension of particles (i.e., cells, blood, nanoparticles, etc.) flowing within the fluid medium of the waveguide. With this customized light intensity pattern, which controls the optical forces introduced by the light confined within the waveguide, and the control of the hydrodynamic forces introduced by the liquid flow (or multiple channel liquid flows), the sorting of particles can be achieved.

    Abstract translation: 本发明涉及一种用于通过组合形成在波导内的定制的光强度图案和稀释颗粒（即细胞，血液，纳米颗粒）的悬浮液来分选在液体芯波导内流动的流体介质中的颗粒的装置 等）在波导的流体介质内流动。 通过这种定制的光强度图案，其控制由限制在波导内的光引入的光学力，以及由液体流（或多通道液体流）引入的流体动力的控制，可以实现颗粒的分选。

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