公开(公告)号：WO2012114347A1

公开(公告)日：2012-08-30

申请号：PCT/IN2011/000295

申请日：2011-04-29

Applicant: AVRA LABORATORIES PVT. LTD. ,  RAMARAO, Chandrashekar ,  NANDIPATI, Ramadevi ,  NAVAKOTI, Rajasekhar ,  KOTTAMASU, Ramanjaneyulu

Inventor： RAMARAO, Chandrashekar ,  NANDIPATI, Ramadevi ,  NAVAKOTI, Rajasekhar ,  KOTTAMASU, Ramanjaneyulu

IPC: C07D493/00 ,  C07D309/00 ,  C07D319/06 ,  C07D319/14

CPC classification number: C07D319/20 ,  C07F9/65522

Abstract: Disclosed herein is a compound of formula (A), its salts, enantiomers, and diastereomers thereof; wherein, Rl and R2 can be (C1-C6) alkyl groups, a phenyl group, a (C5-C7) cycloalkyl groups; X and Y individually selected from H, -N02, -NH2, -OH, -halo, -CHO, -COOH, - COOR, boronic acid-potassium bifluoride boronate salts, boronate esters, aryl, substituted aryl, alkyl or aryl carbamoyl, substituted alkyl or aryl carbamoyl; phosphines(R3R3P) and phosphine oxide of the formula R3R3P=0, where R3 represents an aryl group that can be substituted by one or more (C1-C5) alkyl group, a (C5-C7) cycloalkyl group, (Cl- C4) alkoxy group or di (C1-C4) alkyl amino groups, cyclic hetero aryl group preferably, a 5 membered ring or a halogen.(The R3 groups are normally identical and preferably phenyl groups); wherein both X and Y can be substituted in ortho, para or meta position of the phenyl ring w.r.t the diacetal/ ketal functional group in compound A. The invention also discloses process for preparation of the same.

Abstract translation: 本文公开了式（A）的化合物，其盐，对映异构体和非对映异构体; 其中，R1和R2可以是（C1-C6）烷基，苯基，（C5-C7）环烷基; 分别选自H，-NO 2，-NH 2，-OH， - 卤代，-CHO，-COOH，-COOR，硼酸 - 二氟硼酸钾盐，硼酸酯，芳基，取代的芳基，烷基或芳基氨基甲酰基， 取代的烷基或芳基氨基甲酰基; 膦（R3R3P）和式R3R3P的氧化膦= 0，其中R3表示可被一个或多个（C1-C5）烷基取代的芳基，（C5-C7）环烷基，（C1-C4） 烷氧基或二（C1-C4）烷基氨基，环状杂芳基优选为5元环或卤素（R3基团通常相同，优选为苯基）; 其中X和Y可以在化合物A中的二缩醛/缩酮官能团的苯环的邻位，对位或间位取代。本发明还公开了制备其的方法。

公开(公告)号：WO2016024286A2

公开(公告)日：2016-02-18

申请号：PCT/IN2015/000318

申请日：2015-08-11

Applicant: AVRA LABORATORIES PVT. LTD.

Inventor： RAO, Ramakrishna ,  NANDIPATI, Ramadevi ,  GOODA, Ravi ,  SHEWALKAR, Mukesh, Padmakar ,  BHADKE, Venkat, Vasantrao

CPC classification number: C07D401/04

Abstract: Disclosed herein is an improved process for preparation of Lenalidomide and crystalline polymorphic forms thereof.

Abstract translation: 本文公开了一种改进的来那度胺及其结晶多晶型的制备方法。

公开(公告)号：WO2018042460A1

公开(公告)日：2018-03-08

申请号：PCT/IN2017/050376

申请日：2017-09-01

Applicant: AVRA LABORATORIES PVT. LTD.

Inventor： RAMARAO, Chandrashekar ,  KAMARAJU, Venkata Purnima ,  KANCHARLA, Johny ,  NANDIPATI, Ramadevi

IPC: C08G18/00 ,  C08G71/02 ,  C09J175/02 ,  B01D71/54 ,  C07C335/00 ,  C09D175/00 ,  C12P13/12

CPC classification number: C08G18/3876 ,  C08G18/0866 ,  C08G18/18 ,  C08G18/2018 ,  C08G18/2081 ,  C08G18/3859 ,  C08G18/7607 ,  C08G18/7621 ,  C08G18/7664

Abstract: The present invention discloses sulphur functionalized polyurea composite of Formula (I) and Formula (II) that provides an insoluble solid support for effective removal of metal residues from solvent streams and other reservoirs and to the process for preparation of same thereof.

Abstract translation: 本发明公开了式（I）和式（II）的硫官能化聚脲复合物，其提供了用于有效地从溶剂流和其它储存器中除去金属残余物的不溶性固体载体以及制备方法 的相同。

公开(公告)号：WO2017072790A1

公开(公告)日：2017-05-04

申请号：PCT/IN2016/050362

申请日：2016-10-26

Applicant: AVRA LABORATORIES PVT. LTD.

Inventor： RAO, Ramakrishna ,  NANDIPATI, Ramadevi ,  SHEWALKAR, Mukesh Padmakar ,  BOGIREDDY, Veerabhadra Reddy

IPC: A61K31/519 ,  C07D405/12 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention discloses an improved and cost effective process for preparation of Ticagrelor in good yield and purity. The invention further discloses novel Polymorphic Form of Ticagrelor and its process for preparation thereof.

Abstract translation: 本发明公开了一种以良好收率和纯度制备替格瑞洛的改进的和成本有效的方法。 本发明进一步公开了替格瑞洛的新型多晶型物及其制备方法。

公开(公告)号：WO2012032531A1

公开(公告)日：2012-03-15

申请号：PCT/IN2010/000754

申请日：2010-11-19

Applicant: AVRA LABORATORIES PVT. LTD. ,  ALLA, Venkata, Rama, Rao ,  RAO, Ramakrishna ,  RAMARAO, Chandrashekar ,  NANDIPATI, Ramadevi ,  CHAMLE, Vinay, Avinash

Inventor： ALLA, Venkata, Rama, Rao ,  RAO, Ramakrishna ,  RAMARAO, Chandrashekar ,  NANDIPATI, Ramadevi ,  CHAMLE, Vinay, Avinash

IPC: A01N43/42

CPC classification number: C07D491/22

Abstract: Disclosed herein is a highly safe and easily scalable process for the production of 7-Ethyl- 10-hydroxycamptothecin and its conversion to Irinotecan hydrochloride by total synthesis.

Abstract translation: 本文公开了一种用于生产7-乙基-10-羟基喜树碱及其通过全合成转化为盐酸伊立替康的高度安全且易于扩展的方法。