公开(公告)号：WO2022144924A1

公开(公告)日：2022-07-07

申请号：PCT/IN2021/051218

申请日：2021-12-30

Applicant: AVRA LABORATORIES PVT. LTD.

Inventor： RAO, Ramakrishna ,  SHEWALKAR, Mukesh Padmakar

IPC: A61K31/454 ,  C07D401/04 ,  C07D209/46

Abstract: The present invention discloses an improved process for preparation of Lenalidomide and crystalline polymorphic forms thereof. More particularly, the invention relates to preparation of Lenalidomide with high yields and purity and to preparation of crystalline polymorphic form A and Form B.

公开(公告)号：WO2019092752A2

公开(公告)日：2019-05-16

申请号：PCT/IN2018/050741

申请日：2018-11-13

Applicant: AVRA LABORATORIES PVT. LTD.

Inventor： ALLA, Venkata Rama Rao ,  RAMARAO, Chandrashekar ,  SHEWALKAR, Mukesh Padmakar ,  AMUDALA, Sampath

CPC classification number: C07D401/04 ,  A61P35/00

Abstract: This invention discloses a novel pharmaceutical salt of Lenalidomide. More particularly, the invention discloses crystalline Trifluroacetic acid salt of Lenalidomide; polymorphic forms thereof and process for preparation thereof. The invention further discloses pharmaceutical composition comprising crystalline Trifluroacetic acid salt of Lenalidomide in association with one or more pharmaceutical excipients.

公开(公告)号：WO2019092752A3

公开(公告)日：2019-05-16

申请号：PCT/IN2018/050741

申请日：2018-11-13

Applicant: AVRA LABORATORIES PVT. LTD.

Inventor： ALLA, Venkata Rama Rao ,  RAMARAO, Chandrashekar ,  SHEWALKAR, Mukesh Padmakar ,  AMUDALA, Sampath

IPC: C07D401/04 ,  A61K31/454

Abstract: This invention discloses a novel pharmaceutical salt of Lenalidomide. More particularly, the invention discloses crystalline Trifluroacetic acid salt of Lenalidomide; polymorphic forms thereof and process for preparation thereof. The invention further discloses pharmaceutical composition comprising crystalline Trifluroacetic acid salt of Lenalidomide in association with one or more pharmaceutical excipients.

公开(公告)号：WO2017072790A1

公开(公告)日：2017-05-04

申请号：PCT/IN2016/050362

申请日：2016-10-26

Applicant: AVRA LABORATORIES PVT. LTD.

Inventor： RAO, Ramakrishna ,  NANDIPATI, Ramadevi ,  SHEWALKAR, Mukesh Padmakar ,  BOGIREDDY, Veerabhadra Reddy

IPC: A61K31/519 ,  C07D405/12 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention discloses an improved and cost effective process for preparation of Ticagrelor in good yield and purity. The invention further discloses novel Polymorphic Form of Ticagrelor and its process for preparation thereof.

Abstract translation: 本发明公开了一种以良好收率和纯度制备替格瑞洛的改进的和成本有效的方法。 本发明进一步公开了替格瑞洛的新型多晶型物及其制备方法。