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Patent Agency Ranking
公开(公告)号：WO2011090669A1
公开(公告)日：2011-07-28
申请号：PCT/US2010/061713
申请日：2010-12-22
Applicant: ABBOTT LABORATORIES , LEE, CHIH-Hung , SCHRIMPF, Michael R. , ESBENSHADE, Timothy A. , ZHU, Chang Z.
Inventor： LEE, CHIH-Hung , SCHRIMPF, Michael R. , ESBENSHADE, Timothy A. , ZHU, Chang Z.
CPC classification number: A61K31/46 , A61K31/55 , A61K45/06 , A61K2300/00
Abstract: The present invention is directed to methods of treating pain by administering a therapeutically effective amount of an α7 nAChR ligand or a pharmaceutically acceptable salt thereof, to a mammal in need of treatment thereof and to pharmaceutical compositions comprising such a compound or salt.
Abstract translation: 本发明涉及通过向需要治疗的哺乳动物施用治疗有效量的a7 nAChR配体或其药学上可接受的盐和包含这种化合物或盐的药物组合物来治疗疼痛的方法。
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2.发明申请BRIDGEHEAD AMINE RING -FUSED INDOLES AND INDOLINES USEFUL TO TREAT NEURODEGENERATIVE AND NEUROPSYCHIATRY DISORDERS 审中-公开用于治疗神经损伤和神经损伤疾病的BRIDGEHEAD AMINE RING-FUSED INDOLES和INDOLINES
公开(公告)号：WO2011075487A1
公开(公告)日：2011-06-23
申请号：PCT/US2010/060346
申请日：2010-12-14
Applicant: ABBOTT LABORATORIES , SHI, Lei , BUNNELLE, William H. , LI, Tao , SCANIO, Marc J. , SCHRIMPF, Michael R. , LEE, CHIH-Hung
Inventor： SHI, Lei , BUNNELLE, William H. , LI, Tao , SCANIO, Marc J. , SCHRIMPF, Michael R. , LEE, CHIH-Hung
IPC: C07D471/18 , C07D487/18 , A61K31/407 , A61P25/28
CPC classification number: C07D471/18 , C07D487/18
Abstract: The present application relates to indole and indoline derivatives of formula (I), formula (II), formula (III), or formula (IV) wherein a, R 2 , R 3 , h, k, m, n, L, Q, X, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and their medicaments for treating neurodegeneration and neuropsychiatric disorders.
Abstract translation: 本申请涉及式（I），式（II），式（III）或式（IV）的吲哚和二氢吲哚衍生物，其中a，R2，R3，h，k，m，n，L，Q，X ，Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物及其用于治疗神经变性和神经精神障碍的药物。
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公开(公告)号：WO2011084433A2
公开(公告)日：2011-07-14
申请号：PCT/US2010/060343
申请日：2010-12-14
Applicant: ABBOTT LABORATORIES , SHI, Lei , BUNNELLE, William H. , LI, Tao , SCANIO, Marc J. , SCHRIMPF, Michael R. , LEE, CHIH-Hung
Inventor： SHI, Lei , BUNNELLE, William H. , LI, Tao , SCANIO, Marc J. , SCHRIMPF, Michael R. , LEE, CHIH-Hung
IPC: C07D471/18 , C07D487/18 , A61K31/407 , A61K31/439 , A61P25/28 , A61P25/18
CPC classification number: C07D471/18 , A61K31/439 , A61K31/4439 , A61K31/4709 , C07D487/08
Abstract: The present application relates to indole and indoline derivatives of formula (I) wherein a, R 1 , R 2 , R 3 , h, i, j, m, n, L, Q, and X are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions.
Abstract translation: 本发明涉及式（I）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，h，i，j，m，n，L，Q和X如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法。
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公开(公告)号：EP2525797A1
公开(公告)日：2012-11-28
申请号：EP10801767.4
申请日：2010-12-22
Applicant: Abbott Laboratories
Inventor： LEE, CHIH-Hung , SCHRIMPF, Michael R. , ESBENSHADE, Timothy A. , ZHU, Chang Z.
CPC classification number: A61K31/46 , A61K31/55 , A61K45/06 , A61K2300/00
Abstract: The present invention is directed to methods of treating pain by administering a therapeutically effective amount of an α7 nAChR ligand or a pharmaceutically acceptable salt thereof, to a mammal in need of treatment thereof and to pharmaceutical compositions comprising such a compound or salt.
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5.发明公开BRIDGEHEAD AMINE RING -FUSED INDOLES AND INDOLINES USEFUL TO TREAT NEURODEGENERATIVE AND NEUROPSYCHIATRY DISORDERS 有权BRIDGED AMINE稠环的吲哚和二氢吲哚神经变性的治疗和精神病学障碍NEURO
公开(公告)号：EP2516440A1
公开(公告)日：2012-10-31
申请号：EP10801031.5
申请日：2010-12-14
Applicant: Abbott Laboratories
Inventor： SHI, Lei , BUNNELLE, William H. , LI, Tao , SCANIO, Marc J. , SCHRIMPF, Michael R. , LEE, CHIH-Hung
IPC: C07D471/18 , C07D487/18 , A61K31/407 , A61P25/28
CPC classification number: C07D471/18 , C07D487/18
Abstract: The present application relates to indole and indoline derivatives of formula (I), formula (II), formula (III), or formula (IV) wherein a, R
2 , R
3 , h, k, m, n, L, Q, X, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and their medicaments for treating neurodegeneration and neuropsychiatric disorders.
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