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1.发明申请SUBSTITUTED OCTAHYDROCYCLOPENTA[c]PYRROLES AS CALCIUM CHANNEL MODULATORS 审中-公开取代的OCTAHYDROCYCLOPENTA [c] PYRROLES作为钙通道调节剂
公开(公告)号：WO2011149993A2
公开(公告)日：2011-12-01
申请号：PCT/US2011/037818
申请日：2011-05-24
Applicant: ABBOTT LABORATORIES , SEARLE, Xenia B. , YEUNG, Ming C. , SCHRIMPF, Michael R.
Inventor： SEARLE, Xenia B. , YEUNG, Ming C. , SCHRIMPF, Michael R.
IPC: C07D209/52 , A61P29/00 , A61K31/404
CPC classification number: C07D209/52
Abstract: The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein a, R 1 , R 2 , R 3 , and R 4 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
Abstract translation: 本申请涉及含有式（I）化合物的钙通道抑制剂，其中a，R1，R2，R3和R4如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：WO2011084433A2
公开(公告)日：2011-07-14
申请号：PCT/US2010/060343
申请日：2010-12-14
Applicant: ABBOTT LABORATORIES , SHI, Lei , BUNNELLE, William H. , LI, Tao , SCANIO, Marc J. , SCHRIMPF, Michael R. , LEE, CHIH-Hung
Inventor： SHI, Lei , BUNNELLE, William H. , LI, Tao , SCANIO, Marc J. , SCHRIMPF, Michael R. , LEE, CHIH-Hung
IPC: C07D471/18 , C07D487/18 , A61K31/407 , A61K31/439 , A61P25/28 , A61P25/18
CPC classification number: C07D471/18 , A61K31/439 , A61K31/4439 , A61K31/4709 , C07D487/08
Abstract: The present application relates to indole and indoline derivatives of formula (I) wherein a, R 1 , R 2 , R 3 , h, i, j, m, n, L, Q, and X are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions.
Abstract translation: 本发明涉及式（I）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，h，i，j，m，n，L，Q和X如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法。
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公开(公告)号：WO2010036998A2
公开(公告)日：2010-04-01
申请号：PCT/US2009/058553
申请日：2009-09-28
Applicant: ABBOTT LABORATORIES , SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana , HU, Min
Inventor： SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana , HU, Min
IPC: A61K31/439 , C12Q1/02 , C07D471/08
CPC classification number: G01N33/5058 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/6896 , G01N2800/28 , G01N2800/30
Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R 1 , R 2 , R 3 , R 4 , R 5 , U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Abstract translation: 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。
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4.发明申请BRIDGEHEAD AMINE RING -FUSED INDOLES AND INDOLINES USEFUL TO TREAT NEURODEGENERATIVE AND NEUROPSYCHIATRY DISORDERS 审中-公开用于治疗神经损伤和神经损伤疾病的BRIDGEHEAD AMINE RING-FUSED INDOLES和INDOLINES
公开(公告)号：WO2011075487A1
公开(公告)日：2011-06-23
申请号：PCT/US2010/060346
申请日：2010-12-14
Applicant: ABBOTT LABORATORIES , SHI, Lei , BUNNELLE, William H. , LI, Tao , SCANIO, Marc J. , SCHRIMPF, Michael R. , LEE, CHIH-Hung
Inventor： SHI, Lei , BUNNELLE, William H. , LI, Tao , SCANIO, Marc J. , SCHRIMPF, Michael R. , LEE, CHIH-Hung
IPC: C07D471/18 , C07D487/18 , A61K31/407 , A61P25/28
CPC classification number: C07D471/18 , C07D487/18
Abstract: The present application relates to indole and indoline derivatives of formula (I), formula (II), formula (III), or formula (IV) wherein a, R 2 , R 3 , h, k, m, n, L, Q, X, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and their medicaments for treating neurodegeneration and neuropsychiatric disorders.
Abstract translation: 本申请涉及式（I），式（II），式（III）或式（IV）的吲哚和二氢吲哚衍生物，其中a，R2，R3，h，k，m，n，L，Q，X ，Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物及其用于治疗神经变性和神经精神障碍的药物。
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公开(公告)号：WO2010151815A3
公开(公告)日：2010-12-29
申请号：PCT/US2010/040064
申请日：2010-06-25
Applicant: ABBOTT LABORATORIES , SCHRIMPF, Michael R. , NERSESIAN, Diana L. , LEE, Chih-Hung , FAGHIH, Ramin , GFESSER, Gregory A.
Inventor： SCHRIMPF, Michael R. , NERSESIAN, Diana L. , LEE, Chih-Hung , FAGHIH, Ramin , GFESSER, Gregory A.
IPC: C07D487/10 , C07D471/02 , A61K31/438 , A61P25/28
Abstract: Compounds of formula (I) are useful in treating conditions or disorders ameliorated by α4β2 postive allosteric modulators. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
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Patent Agency Ranking6.发明申请AMIDE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF 审中-公开作为阳性调节剂的酰胺衍生物及其使用方法
公开(公告)号：WO2009100294A2
公开(公告)日：2009-08-13
申请号：PCT/US2009/033329
申请日：2009-02-06
Applicant: ABBOTT LABORATORIES , MORTELL, Kathleen H. , NERSESIAN, Diana L. , SCHRIMPF, Michael R. , LEE, Chih-Hung , GOPALAKRISHNAN, Murali
Inventor： MORTELL, Kathleen H. , NERSESIAN, Diana L. , SCHRIMPF, Michael R. , LEE, Chih-Hung , GOPALAKRISHNAN, Murali
IPC: C07D401/12
CPC classification number: C07D401/12 , C07D209/08 , C07D403/12 , C07D471/04
Abstract: The invention relates to novel amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
Abstract translation: 本发明涉及作为神经元烟碱性受体的PAM的新型酰胺衍生物，包含该酰胺衍生物的组合物，制备该化合物的方法，以及使用这些化合物和组合物的方法。
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公开(公告)号：WO2011090669A1
公开(公告)日：2011-07-28
申请号：PCT/US2010/061713
申请日：2010-12-22
Applicant: ABBOTT LABORATORIES , LEE, CHIH-Hung , SCHRIMPF, Michael R. , ESBENSHADE, Timothy A. , ZHU, Chang Z.
Inventor： LEE, CHIH-Hung , SCHRIMPF, Michael R. , ESBENSHADE, Timothy A. , ZHU, Chang Z.
CPC classification number: A61K31/46 , A61K31/55 , A61K45/06 , A61K2300/00
Abstract: The present invention is directed to methods of treating pain by administering a therapeutically effective amount of an α7 nAChR ligand or a pharmaceutically acceptable salt thereof, to a mammal in need of treatment thereof and to pharmaceutical compositions comprising such a compound or salt.
Abstract translation: 本发明涉及通过向需要治疗的哺乳动物施用治疗有效量的a7 nAChR配体或其药学上可接受的盐和包含这种化合物或盐的药物组合物来治疗疼痛的方法。
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公开(公告)号：WO2011008312A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/027931
申请日：2010-03-19
Applicant: ABBOTT LABORATORIES , SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana L. , HU, Min
Inventor： SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana L. , HU, Min
IPC: C07D487/18
CPC classification number: C07D471/18 , C07D487/18
Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a , R 1 , R 2 , R 3 , R 4 , R 5 , U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Abstract translation: 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和吲哚啉衍生物， R 1，R 2，R 3，R 4，R 5，R 5，R 5，R 4， U，V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含此类化合物的组合物，以及使用此类化合物和组合物治疗疾病状况的方法以及鉴定此类化合物的方法。
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9.发明公开BRIDGEHEAD AMINE RING -FUSED INDOLES AND INDOLINES USEFUL TO TREAT NEURODEGENERATIVE AND NEUROPSYCHIATRY DISORDERS 有权BRIDGED AMINE稠环的吲哚和二氢吲哚神经变性的治疗和精神病学障碍NEURO
公开(公告)号：EP2516440A1
公开(公告)日：2012-10-31
申请号：EP10801031.5
申请日：2010-12-14
Applicant: Abbott Laboratories
Inventor： SHI, Lei , BUNNELLE, William H. , LI, Tao , SCANIO, Marc J. , SCHRIMPF, Michael R. , LEE, CHIH-Hung
IPC: C07D471/18 , C07D487/18 , A61K31/407 , A61P25/28
CPC classification number: C07D471/18 , C07D487/18
Abstract: The present application relates to indole and indoline derivatives of formula (I), formula (II), formula (III), or formula (IV) wherein a, R
2 , R
3 , h, k, m, n, L, Q, X, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and their medicaments for treating neurodegeneration and neuropsychiatric disorders.-
公开(公告)号：EP2101763A2
公开(公告)日：2009-09-23
申请号：EP07869109.4
申请日：2007-12-12
Applicant: ABBOTT LABORATORIES
Inventor： GOPALAKRISHNAN, Murali , HONORE, Marie P. , LEE, Chih-hung , MALYSZ, John , JI, Jianguo , LI, Tao , SCHRIMPF, Michael R. , SIPPY, Kevin B. , ANDERSON, David J.
IPC: A61K31/4245 , A61P25/28 , A61K45/06
CPC classification number: A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
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