公开(公告)号：WO2020198538A1

公开(公告)日：2020-10-01

申请号：PCT/US2020/025078

申请日：2020-03-26

Applicant: AMGEN INC.

Inventor： HWANG, Tsang-Lin ,  WIKSTROEM, Mats H.

IPC: G01N24/08 ,  G01R33/46 ,  G01R33/465 ,  G01R33/485

Abstract: Methods of fingerprinting a specific molecule in a composition using nuclear magnetic resonance (NMR) is disclosed. The disclosed NMR methods provide several modifications and improvements over existing NMR techniques. In some embodiments, the methods include applying a cycle of signal processing steps, including applying a radio frequency (RF) pulse, applying a gradient pulse having a pulse length less than or equal to 1000 µs, and applying a water suppression technique (WET). In some embodiments, the methods further include repeating the cycle for at least 3 times to acquire an enhanced signal of the composition. In some embodiments, the methods further include fingerprinting the specific molecule based on the enhanced signal of the composition.

公开(公告)号：WO2021202452A1

公开(公告)日：2021-10-07

申请号：PCT/US2021/024779

申请日：2021-03-30

Applicant: AMGEN INC.

Inventor： ACHMATOWICZ, Michael ,  CUI, Sheng ,  HWANG, Tsang-Lin ,  LANGILLE, Neil Fred ,  TOM, Janine K. ,  HUCKLE, James E. ,  STEC, Markian ,  WU, Tian ,  BROWN, Sean P.

IPC: C07D519/00 ,  A61P35/00 ,  A61K31/553

Abstract: Disclosed herein is an improved process for the synthesis of compound (A): (A), or a salt or solvate thereof via methylation of compound (B): (B), or a salt or solvate thereof, a crystalline hydrate of compound A, and pharmaceutical formulations comprising a crystalline hydrate of compound (A).

公开(公告)号：EP3948242A1

公开(公告)日：2022-02-09

申请号：EP20723233.1

申请日：2020-03-26

Applicant: Amgen Inc.

Inventor： HWANG, Tsang-Lin ,  WIKSTROEM, Mats H.

IPC: G01N24/08 ,  G01R33/46 ,  G01R33/465 ,  G01R33/485

公开(公告)号：EP4126883A1

公开(公告)日：2023-02-08

申请号：EP21720126.8

申请日：2021-03-30

Applicant: Amgen Inc.

Inventor： ACHMATOWICZ, Michal ,  CUI, Sheng ,  HWANG, Tsang-Lin ,  LANGILLE, Neil Fred ,  TOM, Janine K. ,  HUCKLE, James E. ,  STEC, Markian ,  WU, Tian ,  BROWN, Sean P.

IPC: C07D519/00 ,  A61P35/00 ,  A61K31/553