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公开(公告)号：WO2022046690A1
公开(公告)日：2022-03-03
申请号：PCT/US2021/047237
申请日：2021-08-24
Applicant: AMGEN INC.
Inventor： HUCKLE, James E. , STEC, Markian , WU, Tian , REID, Darren L. , AVAREZ-NUNEZ, Fernando Antonio , BROWN, Sean P.
IPC: A61K9/14 , A61P35/00 , A61K31/553 , C07D519/00
Abstract: Provided herein are solid dispersions comprising AMG 397, methods of preparing the solid dispersion, and pharmaceutical formulations comprising AMG 397.
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公开(公告)号：WO2023004075A1
公开(公告)日：2023-01-26
申请号：PCT/US2022/037928
申请日：2022-07-21
Applicant: AMGEN INC.
Inventor： WU, Tian , AGARWAL, Prashant , ROTHELI, Andreas R. , PARK, Hyunsoo , FROHN, Michael J.
IPC: C07D401/14 , A61P35/00 , A61K31/506
Abstract: Disclosed herein is a salt, a crystalline anhydrous form, a hydrate, a solvate, or a co-crystal of a free base compound 2-(6-azaspiro[2.5]octan-6-yl)-N-[2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl]-4-[(2-hydroxyethanesulfonyl)amino]benzamide (Compound A); method of preparation, pharmaceutical compositions, and method of treating a disease mediated by a motor protein kinesin family member 18A (KIF18A) inhibition, wherein said disease is a neoplastic disease, including a cancer or a tumor.
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公开(公告)号：WO2021202452A1
公开(公告)日：2021-10-07
申请号：PCT/US2021/024779
申请日：2021-03-30
Applicant: AMGEN INC.
Inventor： ACHMATOWICZ, Michael , CUI, Sheng , HWANG, Tsang-Lin , LANGILLE, Neil Fred , TOM, Janine K. , HUCKLE, James E. , STEC, Markian , WU, Tian , BROWN, Sean P.
IPC: C07D519/00 , A61P35/00 , A61K31/553
Abstract: Disclosed herein is an improved process for the synthesis of compound (A): (A), or a salt or solvate thereof via methylation of compound (B): (B), or a salt or solvate thereof, a crystalline hydrate of compound A, and pharmaceutical formulations comprising a crystalline hydrate of compound (A).
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公开(公告)号：WO2022140497A1
公开(公告)日：2022-06-30
申请号：PCT/US2021/064773
申请日：2021-12-22
Inventor： WU, Tian , SCHNEIDER, Michael , KHALAF, Ryan , SMYTH, Hugh , BRUNAUGH, Ashlee , DING, Li
IPC: G16H20/10
Abstract: A forecasting modeling computing system includes a processors and a memory including a set of computer-executable instructions that, when executed by the processor, cause the forecasting modeling computing system to receive design parameters, determine a predicted median particle size, identify a predictive quadratic model, and display a response surface visualization. A computer-implemented method includes receiving design parameters, determining a predicted median particle size, identifying a predictive quadratic model; and display a response surface visualization.
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公开(公告)号：EP4373818A1
公开(公告)日：2024-05-29
申请号：EP22761662.0
申请日：2022-07-21
Applicant: AMGEN INC.
Inventor： WU, Tian , AGARWAL, Prashant , ROTHELI, Andreas R. , PARK, Hyunsoo , FROHN, Michael J.
IPC: C07D401/14 , A61P35/00 , A61K31/506
CPC classification number: C07D401/14 , A61P35/00
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Patent Agency Ranking
公开(公告)号：EP4268235A1
公开(公告)日：2023-11-01
申请号：EP21848381.6
申请日：2021-12-22
Inventor： WU, Tian , SCHNEIDER, Michael , KHALAF, Ryan , SMYTH, Hugh , BRUNAUGH, Ashlee , DING, Li
IPC: G16H20/10
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公开(公告)号：EP4203922A1
公开(公告)日：2023-07-05
申请号：EP21772900.3
申请日：2021-08-24
Applicant: Amgen Inc.
Inventor： HUCKLE, James E. , STEC, Markian , WU, Tian , REID, Darren L. , AVAREZ-NUNEZ, Fernando Antonio , BROWN, Sean P.
IPC: A61K9/14 , A61P35/00 , A61K31/553 , C07D519/00
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公开(公告)号：EP4472985A1
公开(公告)日：2024-12-11
申请号：EP23718377.7
申请日：2023-02-03
Applicant: Amgen Inc.
Inventor： KELLY, Ron, C. , CHAVES, Mary , TENG, Jing , PARENT, Stephan , LUU, Van , FARRELL, Robert, P. , HUCKLE, James, E. , ACHMATOWICZ, Michal , WU, Tian , REID, Darren, L , XIAO, Lingyun
IPC: C07D519/00 , A61P35/00 , A61K31/553
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公开(公告)号：EP4472984A1
公开(公告)日：2024-12-11
申请号：EP23710498.9
申请日：2023-02-03
Applicant: Amgen Inc.
Inventor： KELLY, Ron, C. , CHAVES, Mary , TENG, Jing , PARENT, Stephan , STEC, Markian , LUU, Van , FARRELL, Robert, P. , HUCKLE, James, E. , ACHMATOWICZ, Michal , WU, Tian , REID, Darren, L. , XIAO, Lingyun
IPC: C07D519/00 , A61K31/553 , A61P35/00
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公开(公告)号：EP4126883A1
公开(公告)日：2023-02-08
申请号：EP21720126.8
申请日：2021-03-30
Applicant: Amgen Inc.
Inventor： ACHMATOWICZ, Michal , CUI, Sheng , HWANG, Tsang-Lin , LANGILLE, Neil Fred , TOM, Janine K. , HUCKLE, James E. , STEC, Markian , WU, Tian , BROWN, Sean P.
IPC: C07D519/00 , A61P35/00 , A61K31/553
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