公开(公告)号：WO2019006231A1

公开(公告)日：2019-01-03

申请号：PCT/US2018/040176

申请日：2018-06-29

Applicant: AMGEN INC.

Inventor： CAILLE, Sebastien ,  QUASDORF, Kyle ,  ROOSEN, Philipp ,  SHI, Xianqing ,  COSBIE, Andrew ,  WANG, Fang ,  WU, Zufan ,  NEERGUNDA, Archana ,  QUAN, Bin, Peter ,  GUAN, Lianxiu

IPC: C07D295/205 ,  C07D213/75

Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates. (I)

公开(公告)号：EP3925950A1

公开(公告)日：2021-12-22

申请号：EP21174262.2

申请日：2018-06-29

Applicant: Amgen Inc.

Inventor： CAILLE, Sebastien ,  QUASDORF, Kyle ,  ROOSEN, Philipp ,  SHI, Xianqing ,  COSBIE, Andrew ,  WANG, Fang ,  WU, Zufan ,  NEERGUNDA, Archana ,  QUAN, Peter Bin ,  GUAN, Lianxiu

IPC: C07D213/75

Abstract: The invention relates to a process for preparing omecamtiv mecarbil free base and omecamtiv mecarbil dihydrochloride hydrate.

公开(公告)号：EP4265597A2

公开(公告)日：2023-10-25

申请号：EP23189293.6

申请日：2018-06-29

Applicant: Amgen Inc.

Inventor： CAILLE, Sebastien ,  QUASDORF, Kyle ,  ROOSEN, Philipp ,  SHI, Xianqing ,  COSBIE, Andrew ,  WANG, Fang ,  WU, Zufan ,  NEERGUNDA, Archana ,  QUAN, Peter Bin ,  GUAN, Lianxiu

IPC: C07D213/75

Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.

公开(公告)号：EP4265597A3

公开(公告)日：2023-11-22

申请号：EP23189293.6

申请日：2018-06-29

Applicant: Amgen Inc.

Inventor： CAILLE, Sebastien ,  QUASDORF, Kyle ,  ROOSEN, Philipp ,  SHI, Xianqing ,  COSBIE, Andrew ,  WANG, Fang ,  WU, Zufan ,  NEERGUNDA, Archana ,  QUAN, Peter Bin ,  GUAN, Lianxiu

IPC: C07D213/75

Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.

公开(公告)号：EP3645518A1

公开(公告)日：2020-05-06

申请号：EP18743314.9

申请日：2018-06-29

Applicant: Amgen Inc.

Inventor： CAILLE, Sebastien ,  QUASDORF, Kyle ,  ROOSEN, Philipp ,  SHI, Xianqing ,  COSBIE, Andrew ,  WANG, Fang ,  WU, Zufan ,  NEERGUNDA, Archana ,  QUAN, Bin, Peter ,  GUAN, Lianxiu

IPC: C07D295/205 ,  C07D213/75