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公开(公告)号：WO2011025938A2
公开(公告)日：2011-03-03
申请号：PCT/US2010/046952
申请日：2010-08-27
Applicant: ARRAY BIOPHARMA INC. , GENENTECH, INC. , ALIAGAS, Ignacio , GRADL, Stefan , GUNZNER, Janet , LEE, Wendy , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , ZHAO, Guiling , BUCKMELTER, Alexandre J. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen , MORENO, David , REN, Li , WENGLOWSKY, Steven Mark
Inventor： ALIAGAS, Ignacio , GRADL, Stefan , GUNZNER, Janet , LEE, Wendy , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , ZHAO, Guiling , BUCKMELTER, Alexandre J. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen , MORENO, David , REN, Li , WENGLOWSKY, Steven Mark
IPC: A61K31/5377 , C07D487/02
CPC classification number: C07D239/94 , C07D403/12 , C07D405/12 , C07D471/04
Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 式I化合物可用于抑制Raf激酶。 使用式I化合物及其立体异构体，互变异构体，前药和药学上可接受的盐用于体外，原位和体内诊断，预防或治疗的方法 披露了哺乳动物细胞中的病症或相关的病理学病症。
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公开(公告)号：WO2009111278A3
公开(公告)日：2009-09-11
申请号：PCT/US2009/035380
申请日：2009-02-27
Applicant: ARRAY BIOPHARMA INC. , GENENTECH, INC. , AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , MORENO, David , NEWHOUSE, Brad , REN, Li , WENGLOWSKY, Steven Mark , FENG, Bainian , GUNZNER, Janet , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B.
Inventor： AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , MORENO, David , NEWHOUSE, Brad , REN, Li , WENGLOWSKY, Steven Mark , FENG, Bainian , GUNZNER, Janet , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B.
IPC: C07D471/04 , C07C311/08 , A61P35/00 , A61K31/437
Abstract: Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I) and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：WO2009111279A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/035381
申请日：2009-02-27
Applicant: ARRAY BIOPHARMA INC. , GENENTECH, INC. , AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , DE MEESE, Jason , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , LUNGHOFER, Paul , MORENO, David , NEWHOUSE, Brad , REN, Li , SEO, Jeongbeob , TIAN, Hongqi , WENGLOWSKY, Steven Mark , FENG, Bainian , GUNZNER, Janet , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B.
Inventor： AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , DE MEESE, Jason , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , LUNGHOFER, Paul , MORENO, David , NEWHOUSE, Brad , REN, Li , SEO, Jeongbeob , TIAN, Hongqi , WENGLOWSKY, Steven Mark , FENG, Bainian , GUNZNER, Janet , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B.
IPC: C07D471/04 , C07C311/08 , A61K31/437 , A61P13/12 , A61P35/00
CPC classification number: C07D471/04 , C07C311/08
Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 式I化合物可用于抑制Raf激酶。 公开了使用式I化合物和立体异构体，互变异构体，前药和其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：WO2008028141A3
公开(公告)日：2008-03-06
申请号：PCT/US2007/077411
申请日：2007-08-31
Applicant: ARRAY BIOPHARMA INC. , BUCKMELTER, Alexandre J. , LYSSIKATOS, Joseph P. , MIKNIS, Greg , REN, Li , WENGLOWSKY, Steven Mark
Inventor： BUCKMELTER, Alexandre J. , LYSSIKATOS, Joseph P. , MIKNIS, Greg , REN, Li , WENGLOWSKY, Steven Mark
IPC: C07D491/04 , A61K31/4741 , A61P35/00
Abstract: Compounds of Formulas (I), (IIA) and (IIIA) are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formulas (I), (IIA) and (IIIA) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：WO2007027855A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/033976
申请日：2006-08-31
Applicant: ARRAY BIOPHARMA INC. , MIKNIS, Greg , LYSSIKATOS, Joseph P. , LAIRD, Ellen , TARLTON, Eugene , BUCKMELTER, Alexandre J. , REN, Li , RAST, Bryson , SCHLACTER, Stephen T. , WENGLOWSKY, Steven Mark
Inventor： MIKNIS, Greg , LYSSIKATOS, Joseph P. , LAIRD, Ellen , TARLTON, Eugene , BUCKMELTER, Alexandre J. , REN, Li , RAST, Bryson , SCHLACTER, Stephen T. , WENGLOWSKY, Steven Mark
CPC classification number: C07D491/04 , C07D495/04
Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 式I的化合物可用于抑制Raf激酶和用于治疗由此介导的病症。 使用式I化合物及其立体异构体，几何异构体，互变异构体，溶剂合物及其药学上可接受的盐的方法用于在哺乳动物细胞或相关病理状况下的体外，原位和体内诊断，预防或治疗这些疾病。 披露。
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Patent Agency Ranking6.发明申请N- (6-AMINOPYRIDIN-3-YL) -3- (SULFONAMIDO) BENZAMIDE DERIVATIVES AS B-RAF INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开作为治疗癌症的B-RAF抑制剂的N-（6-氨基吡啶-3-基）-3-（磺酰胺基）苯甲酰胺衍生物
公开(公告)号：WO2009111280A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/035383
申请日：2009-02-27
Applicant: ARRAY BIOPHARMA INC. , GENENTECH, INC. , AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , NEWHOUSE, Brad , REN, Li , WENGLOWSKY, Steven Mark , FENG, Bainian , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B. , MORENO, David, A.
Inventor： AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , NEWHOUSE, Brad , REN, Li , WENGLOWSKY, Steven Mark , FENG, Bainian , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B. , MORENO, David, A.
IPC: C07C311/08 , C07D213/75 , A61K31/44 , A61P35/00
CPC classification number: C07D213/75 , C07C311/48 , C07D213/80 , C07D213/82 , C07D213/85 , C07D401/04 , C07D401/06 , C07D405/04 , C07D417/04
Abstract: Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 式（I）的化合物可用于抑制Raf激酶。 公开了使用式I化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：EP2265608A2
公开(公告)日：2010-12-29
申请号：EP09716491.7
申请日：2009-02-27
Applicant: Array Biopharma, Inc. , Genentech, Inc.
Inventor： AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , MORENO, David , NEWHOUSE, Brad , REN, Li , WENGLOWSKY, Steven Mark , FENG, Bainian , GUNZNER, Janet , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B.
IPC: C07D471/04
CPC classification number: C07D471/04 , C07C311/08
Abstract: Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I) and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：EP2265610A1
公开(公告)日：2010-12-29
申请号：EP09718306.5
申请日：2009-02-27
Applicant: Array Biopharma, Inc. , Genentech, Inc.
Inventor： AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , DE MEESE, Jason , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , LUNGHOFER, Paul , MORENO, David , NEWHOUSE, Brad , REN, Li , SEO, Jeongbeob , TIAN, Hongqi , WENGLOWSKY, Steven Mark , FENG, Bainian , GUNZNER, Janet , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B.
IPC: C07D471/04 , C07C311/08 , A61K31/437 , A61P13/12 , A61P35/00
CPC classification number: C07D471/04 , C07C311/08
Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro,
in situ, and
in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.-
公开(公告)号：EP2057168A2
公开(公告)日：2009-05-13
申请号：EP07841737.5
申请日：2007-08-31
Applicant: Array Biopharma, Inc.
Inventor： BUCKMELTER, Alexandre J. , LYSSIKATOS, Joseph P. , MIKNIS, Greg , REN, Li , WENGLOWSKY, Steven Mark ,
IPC: C07D491/04 , A61K31/4741 , A61P35/00
CPC classification number: C07D491/04
Abstract: Compounds of Formulas (I), (IIA) and (IIIA) are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formulas (I), (IIA) and (IIIA) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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10.发明公开N- (6-AMINOPYRIDIN-3-YL) -3- (SULFONAMIDO) BENZAMIDE DERIVATIVES AS B-RAF INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开N-（6-氨基吡啶-3-基）-3-（磺酰氨基）苯甲酰胺衍生物AS B-RAF抑制剂用于治疗癌症的
公开(公告)号：EP2265574A1
公开(公告)日：2010-12-29
申请号：EP09716477.6
申请日：2009-02-27
Applicant: Array Biopharma, Inc. , Genentech, Inc.
Inventor： AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , NEWHOUSE, Brad , REN, Li , WENGLOWSKY, Steven Mark , FENG, Bainian , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B. , MORENO, David, A.
IPC: C07C311/08 , C07D213/75 , A61K31/44 , A61P35/00
CPC classification number: C07D213/75 , C07C311/48 , C07D213/80 , C07D213/82 , C07D213/85 , C07D401/04 , C07D401/06 , C07D405/04 , C07D417/04
Abstract: Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for
in vitro ,
in situ , and
in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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