公开(公告)号：WO2007103308A3

公开(公告)日：2007-09-13

申请号：PCT/US2007/005583

申请日：2007-03-06

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  BLAKE, James F. ,  BOYD, Steven Armen ,  COHEN, Frederick ,  DE MEESE, Jason ,  FONG, Kin Chiu ,  GAUDINO, John J. ,  KAPLAN, Tomas ,  MARLOW, Allison L. ,  SEO, Jeongbeob ,  THOMAS, Allen A. ,  TIAN, Hongqi ,  YOUNG, Wendy B.

Inventor： BLAKE, James F. ,  BOYD, Steven Armen ,  COHEN, Frederick ,  DE MEESE, Jason ,  FONG, Kin Chiu ,  GAUDINO, John J. ,  KAPLAN, Tomas ,  MARLOW, Allison L. ,  SEO, Jeongbeob ,  THOMAS, Allen A. ,  TIAN, Hongqi ,  YOUNG, Wendy B.

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: Compounds of Formulas (Ia) and (Ib), and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：WO2012118850A1

公开(公告)日：2012-09-07

申请号：PCT/US2012/027009

申请日：2012-02-28

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  BLAKE, James F. ,  CHEN, Huifen ,  CHICARELLI, Mark Joseph ,  DEMEESE, Jason ,  GARREY, Rustam ,  GAUDINO, John J. ,  KAUS, Robert J. ,  KOLAKOWSKI, Gabrielle R. ,  MARLOW, Allison L. ,  MOHR, Peter J. ,  REN, Li ,  SCHWARZ, Jacob ,  SIEDEM, Christopher S. ,  THOMAS, Allen A. ,  WALLACE, Eli ,  WENGLOWSKY, Steven Mark

Inventor： BLAKE, James F. ,  CHEN, Huifen ,  CHICARELLI, Mark Joseph ,  DEMEESE, Jason ,  GARREY, Rustam ,  GAUDINO, John J. ,  KAUS, Robert J. ,  KOLAKOWSKI, Gabrielle R. ,  MARLOW, Allison L. ,  MOHR, Peter J. ,  REN, Li ,  SCHWARZ, Jacob ,  SIEDEM, Christopher S. ,  THOMAS, Allen A. ,  WALLACE, Eli ,  WENGLOWSKY, Steven Mark

IPC: C07D471/04 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D471/04 ,  A61K31/519 ,  A61K45/06 ,  C07D491/052

Abstract: Compounds having the formula I wherein Z, Z 1 Z 2 Z 3 , R 3a , R 3b and R b and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.

Abstract translation: 具有式I的化合物，其中Z，Z 1 Z 2 Z 3，R 3a，R 3b和R b如本文所定义是ERK激酶的抑制剂。 还公开了用于治疗过度增殖性疾病的组合物和方法。

公开(公告)号：WO2013078254A1

公开(公告)日：2013-05-30

申请号：PCT/US2012/066153

申请日：2012-11-20

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  SKELTON, Nicholas ,  GRADL, Stefan ,  BLAKE, James F. ,  GRAHAM, James M. ,  GUNAWARDANA, Indrani W. ,  HENTEMANN, Martin ,  MARLOW, Allison L. ,  TANG, Tony P.

Inventor： SKELTON, Nicholas ,  GRADL, Stefan ,  BLAKE, James F. ,  GRAHAM, James M. ,  GUNAWARDANA, Indrani W. ,  HENTEMANN, Martin ,  MARLOW, Allison L. ,  TANG, Tony P.

IPC: C07D471/04 ,  C07D487/04 ,  A61K31/4188 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula 1: wherein Het, X, R 1 and R 2 are as defined herein.

Abstract translation: 本发明提供包括拆分的对映异构体，分解的非对映异构体，溶剂化物和药学上可接受的盐的化合物，其包含式1：其中Het，X，R 1和R 2如本文所定义。

公开(公告)号：WO2007146824A2

公开(公告)日：2007-12-21

申请号：PCT/US2007/070787

申请日：2007-06-08

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  GAUDINO, John ,  BOYD, Steven Armen ,  MARLOW, Allison L. ,  KAPLAN, Tomas ,  FONG, Kin Chiu ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  BLAKE, James ,  KOCH, Kevin

Inventor： GAUDINO, John ,  BOYD, Steven Armen ,  MARLOW, Allison L. ,  KAPLAN, Tomas ,  FONG, Kin Chiu ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  BLAKE, James ,  KOCH, Kevin

IPC: C07D215/22

CPC classification number: C07D401/14 ,  C07D215/22 ,  C07D401/12

Abstract: Compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof, are useful for inhibiting receptor tyrosine kinases and for treating hyperproliferative disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. [ Formula I]

Abstract translation: 式I化合物和立体异构体，几何异构体，互变异构体，溶剂合物，代谢物，盐和药学上可接受的前药可用于抑制受体酪氨酸激酶和用于治疗由此介导的过度增殖性疾病。 使用式I化合物及其立体异构体，几何异构体，互变异构体，溶剂合物及其药学上可接受的盐在哺乳动物细胞或相关病理状况下的体外，原位和体内诊断，预防或治疗这些病症的方法是 披露。 [公式I]

公开(公告)号：EP2032538A2

公开(公告)日：2009-03-11

申请号：EP07798333.6

申请日：2007-06-08

Applicant: Array Biopharma, Inc.

Inventor： GAUDINO, John ,  BOYD, Steven Armen ,  MARLOW, Allison L. ,  KAPLAN, Tomas ,  FONG, Kin Chiu ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  BLAKE, James ,  KOCH, Kevin

IPC: C07D215/22

CPC classification number: C07D401/14 ,  C07D215/22 ,  C07D401/12

Abstract: Compounds of Formula (I), and stereoisomers, geometric isomers, tautomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof, are useful for inhibiting receptor tyrosine kinases and for treating hyperproliferative disorders mediated thereby. Methods of using compounds of Formula (I), and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP2681215A1

公开(公告)日：2014-01-08

申请号：EP12709429.0

申请日：2012-02-28

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： BLAKE, James F. ,  CHEN, Huifen ,  CHICARELLI, Mark Joseph ,  DEMEESE, Jason ,  GARREY, Rustam ,  GAUDINO, John J. ,  KAUS, Robert J. ,  KOLAKOWSKI, Gabrielle R. ,  MARLOW, Allison L. ,  MOHR, Peter J. ,  REN, Li ,  SCHWARZ, Jacob ,  SIEDEM, Christopher S. ,  THOMAS, Allen A. ,  WALLACE, Eli ,  WENGLOWSKY, Steven Mark

IPC: C07D471/04 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D471/04 ,  A61K31/519 ,  A61K45/06 ,  C07D491/052

Abstract: Compounds having the formula I wherein Z, Z1 Z2 Z, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.

公开(公告)号：EP2681215B1

公开(公告)日：2015-04-22

申请号：EP12709429.0

申请日：2012-02-28

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： BLAKE, James F. ,  CHEN, Huifen ,  CHICARELLI, Mark Joseph ,  DEMEESE, Jason ,  GARREY, Rustam ,  GAUDINO, John J. ,  KAUS, Robert J. ,  KOLAKOWSKI, Gabrielle R. ,  MARLOW, Allison L. ,  MOHR, Peter J. ,  REN, Li ,  SCHWARZ, Jacob ,  SIEDEM, Christopher S. ,  THOMAS, Allen A. ,  WALLACE, Eli ,  WENGLOWSKY, Steven Mark ,  BOYD, Steven

IPC: C07D471/04 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D471/04 ,  A61K31/519 ,  A61K45/06 ,  C07D491/052

公开(公告)号：EP2001880A2

公开(公告)日：2008-12-17

申请号：EP07752297.7

申请日：2007-03-06

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： BLAKE, James F. ,  BOYD, Steven Armen ,  COHEN, Frederick ,  DE MEESE, Jason ,  FONG, Kin Chiu ,  GAUDINO, John J. ,  KAPLAN, Tomas ,  MARLOW, Allison L. ,  SEO, Jeongbeob ,  THOMAS, Allen A. ,  TIAN, Hongqi ,  YOUNG, Wendy B.

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: Compounds of Formulas (Ia) and (Ib), and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP1989211A2

公开(公告)日：2008-11-12

申请号：EP07870652.0

申请日：2007-01-30

Applicant: Array Biopharma, Inc.

Inventor： BLAKE, James, F. ,  BOYD, Steven ,  DE MEESE, Jason ,  GAUDINO, John J. ,  MARLOW, Allison L. ,  SEO, Jeongbeob ,  THOMAS, Allen A. ,  TIAN, Hongqi

IPC: C07D495/04

CPC classification number: C07D495/04 ,  C07D519/00

Abstract: Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.