公开(公告)号：WO2008063202A3

公开(公告)日：2008-05-29

申请号：PCT/US2007/002352

申请日：2007-01-30

Applicant: ARRAY BIOPHARMA INC. ,  BLAKE, James, F. ,  BOYD, Steven ,  DE MEESE, Jason ,  GAUDINO, John, J. ,  MARLOW, Allison, L. ,  SEO, Jeongbeob ,  THOMAS, Allen, A. ,  TIAN, Hongqi

Inventor： BLAKE, James, F. ,  BOYD, Steven ,  DE MEESE, Jason ,  GAUDINO, John, J. ,  MARLOW, Allison, L. ,  SEO, Jeongbeob ,  THOMAS, Allen, A. ,  TIAN, Hongqi

IPC: C07D495/04 ,  C07D519/00 ,  A61K31/4353 ,  A61P35/00

Abstract: Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：WO2007146824A2

公开(公告)日：2007-12-21

申请号：PCT/US2007/070787

申请日：2007-06-08

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  GAUDINO, John ,  BOYD, Steven Armen ,  MARLOW, Allison L. ,  KAPLAN, Tomas ,  FONG, Kin Chiu ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  BLAKE, James ,  KOCH, Kevin

Inventor： GAUDINO, John ,  BOYD, Steven Armen ,  MARLOW, Allison L. ,  KAPLAN, Tomas ,  FONG, Kin Chiu ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  BLAKE, James ,  KOCH, Kevin

IPC: C07D215/22

CPC classification number: C07D401/14 ,  C07D215/22 ,  C07D401/12

Abstract: Compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof, are useful for inhibiting receptor tyrosine kinases and for treating hyperproliferative disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. [ Formula I]

Abstract translation: 式I化合物和立体异构体，几何异构体，互变异构体，溶剂合物，代谢物，盐和药学上可接受的前药可用于抑制受体酪氨酸激酶和用于治疗由此介导的过度增殖性疾病。 使用式I化合物及其立体异构体，几何异构体，互变异构体，溶剂合物及其药学上可接受的盐在哺乳动物细胞或相关病理状况下的体外，原位和体内诊断，预防或治疗这些病症的方法是 披露。 [公式I]

公开(公告)号：WO2009111279A1

公开(公告)日：2009-09-11

申请号：PCT/US2009/035381

申请日：2009-02-27

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  AHRENDT, Kateri A. ,  BUCKMELTER, Alexandre J. ,  DE MEESE, Jason ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen R. ,  LUNGHOFER, Paul ,  MORENO, David ,  NEWHOUSE, Brad ,  REN, Li ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  WENGLOWSKY, Steven Mark ,  FENG, Bainian ,  GUNZNER, Janet ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy B.

Inventor： AHRENDT, Kateri A. ,  BUCKMELTER, Alexandre J. ,  DE MEESE, Jason ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen R. ,  LUNGHOFER, Paul ,  MORENO, David ,  NEWHOUSE, Brad ,  REN, Li ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  WENGLOWSKY, Steven Mark ,  FENG, Bainian ,  GUNZNER, Janet ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy B.

IPC: C07D471/04 ,  C07C311/08 ,  A61K31/437 ,  A61P13/12 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07C311/08

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式I化合物可用于抑制Raf激酶。 公开了使用式I化合物和立体异构体，互变异构体，前药和其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：WO2007103308A3

公开(公告)日：2007-09-13

申请号：PCT/US2007/005583

申请日：2007-03-06

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  BLAKE, James F. ,  BOYD, Steven Armen ,  COHEN, Frederick ,  DE MEESE, Jason ,  FONG, Kin Chiu ,  GAUDINO, John J. ,  KAPLAN, Tomas ,  MARLOW, Allison L. ,  SEO, Jeongbeob ,  THOMAS, Allen A. ,  TIAN, Hongqi ,  YOUNG, Wendy B.

Inventor： BLAKE, James F. ,  BOYD, Steven Armen ,  COHEN, Frederick ,  DE MEESE, Jason ,  FONG, Kin Chiu ,  GAUDINO, John J. ,  KAPLAN, Tomas ,  MARLOW, Allison L. ,  SEO, Jeongbeob ,  THOMAS, Allen A. ,  TIAN, Hongqi ,  YOUNG, Wendy B.

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: Compounds of Formulas (Ia) and (Ib), and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP2265610A1

公开(公告)日：2010-12-29

申请号：EP09718306.5

申请日：2009-02-27

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： AHRENDT, Kateri A. ,  BUCKMELTER, Alexandre J. ,  DE MEESE, Jason ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen R. ,  LUNGHOFER, Paul ,  MORENO, David ,  NEWHOUSE, Brad ,  REN, Li ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  WENGLOWSKY, Steven Mark ,  FENG, Bainian ,  GUNZNER, Janet ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy B.

IPC: C07D471/04 ,  C07C311/08 ,  A61K31/437 ,  A61P13/12 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07C311/08

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro,
in situ, and
in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP2001880A2

公开(公告)日：2008-12-17

申请号：EP07752297.7

申请日：2007-03-06

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： BLAKE, James F. ,  BOYD, Steven Armen ,  COHEN, Frederick ,  DE MEESE, Jason ,  FONG, Kin Chiu ,  GAUDINO, John J. ,  KAPLAN, Tomas ,  MARLOW, Allison L. ,  SEO, Jeongbeob ,  THOMAS, Allen A. ,  TIAN, Hongqi ,  YOUNG, Wendy B.

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: Compounds of Formulas (Ia) and (Ib), and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP1989211A2

公开(公告)日：2008-11-12

申请号：EP07870652.0

申请日：2007-01-30

Applicant: Array Biopharma, Inc.

Inventor： BLAKE, James, F. ,  BOYD, Steven ,  DE MEESE, Jason ,  GAUDINO, John J. ,  MARLOW, Allison L. ,  SEO, Jeongbeob ,  THOMAS, Allen A. ,  TIAN, Hongqi

IPC: C07D495/04

CPC classification number: C07D495/04 ,  C07D519/00

Abstract: Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP2193130A1

公开(公告)日：2010-06-09

申请号：EP08799257.4

申请日：2008-09-05

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： DEMEESE, Jason ,  GAUDINO, John ,  NEITZEL, Alicia, Tarin ,  LUNGHOFER, Paul ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  YOUNG, Wendy, B. ,  SUTHERLIN, Daniel, P.

IPC: C07D471/04 ,  A61P35/00 ,  A61K31/437

CPC classification number: C07D471/04

Abstract: Compounds of Formulas Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP2265610B1

公开(公告)日：2012-12-12

申请号：EP09718306.5

申请日：2009-02-27

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： AHRENDT, Kateri A. ,  BUCKMELTER, Alexandre J. ,  DE MEESE, Jason ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen R. ,  LUNGHOFER, Paul ,  MORENO, David ,  NEWHOUSE, Brad ,  REN, Li ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  WENGLOWSKY, Steven Mark ,  FENG, Bainian ,  GUNZNER, Janet ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy B.

IPC: C07D471/04 ,  C07C311/08 ,  A61K31/437 ,  A61P13/12 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07C311/08

公开(公告)号：EP2032538A2

公开(公告)日：2009-03-11

申请号：EP07798333.6

申请日：2007-06-08

Applicant: Array Biopharma, Inc.

Inventor： GAUDINO, John ,  BOYD, Steven Armen ,  MARLOW, Allison L. ,  KAPLAN, Tomas ,  FONG, Kin Chiu ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  BLAKE, James ,  KOCH, Kevin

IPC: C07D215/22

CPC classification number: C07D401/14 ,  C07D215/22 ,  C07D401/12

Abstract: Compounds of Formula (I), and stereoisomers, geometric isomers, tautomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof, are useful for inhibiting receptor tyrosine kinases and for treating hyperproliferative disorders mediated thereby. Methods of using compounds of Formula (I), and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.