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公开(公告)号：WO2012040641A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/053118
申请日：2011-09-23
Applicant: ARRAY BIOPHARMA INC. , HUNT, Kevin W. , TANG, Tony P. , THOMAS, Allen A.
Inventor： HUNT, Kevin W. , TANG, Tony P. , THOMAS, Allen A.
IPC: C07D491/107 , C07D491/20 , A61K31/4188 , A61P25/28
CPC classification number: A61K31/4188 , C07D491/107 , C07D491/20
Abstract: The invention provides novel tricyclic compounds of Formula I' that inhibit β-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.
Abstract translation: 本发明提供抑制APP的β-分泌酶切割的新颖的式I'三环化合物，并且可用作治疗神经变性疾病的治疗剂。
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公开(公告)号：WO2013078254A1
公开(公告)日：2013-05-30
申请号：PCT/US2012/066153
申请日：2012-11-20
Applicant: ARRAY BIOPHARMA INC. , GENENTECH, INC. , SKELTON, Nicholas , GRADL, Stefan , BLAKE, James F. , GRAHAM, James M. , GUNAWARDANA, Indrani W. , HENTEMANN, Martin , MARLOW, Allison L. , TANG, Tony P.
Inventor： SKELTON, Nicholas , GRADL, Stefan , BLAKE, James F. , GRAHAM, James M. , GUNAWARDANA, Indrani W. , HENTEMANN, Martin , MARLOW, Allison L. , TANG, Tony P.
IPC: C07D471/04 , C07D487/04 , A61K31/4188 , A61P35/00
CPC classification number: C07D471/04 , C07D487/04
Abstract: The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula 1: wherein Het, X, R 1 and R 2 are as defined herein.
Abstract translation: 本发明提供包括拆分的对映异构体，分解的非对映异构体，溶剂化物和药学上可接受的盐的化合物，其包含式1：其中Het，X，R 1和R 2如本文所定义。
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公开(公告)号：WO2021041671A1
公开(公告)日：2021-03-04
申请号：PCT/US2020/048194
申请日：2020-08-27
Applicant: MIRATI THERAPEUTICS, INC. , ARRAY BIOPHARMA INC.
Inventor： WANG, Xiaolun , BURNS, Aaron Craig , CHRISTENSEN, James Gail , KETCHAM, John Michael , LAWSON, John David , MARX, Matthew Arnold , SMITH, Christopher Ronald , ALLEN, Shelley , BLAKE, James Francis , CHICARELLI, Mark Joseph , DAHLKE, Joshua Ryan , DAI, Donghua , FELL, Jay Bradford , FISCHER, John Peter , MEJIA, Macedonio J. , NEWHOUSE, Brad , NGUYEN, Phong , O'LEARY, Jacob Matthew , PAJK, Spencer , RODRIGUEZ, Martha E. , SAVECHENKOV, Pavel , TANG, Tony P. , VIGERS, Guy P. A. , ZHAO, Qian
IPC: A61K31/435 , A61K31/4375 , A61K31/517 , C07D471/00 , C07D471/02 , C07D471/04
Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.
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4.发明申请
公开(公告)号：WO2009089454A1
公开(公告)日：2009-07-16
申请号：PCT/US2009/030603
申请日：2009-01-09
Applicant: ARRAY BIOPHARMA INC. , BANKA, Anna , BENCSIK, Josef R. , BLAKE, James F. , FONG, Kin Chiu , HENTEMANN, Martin F. , MITCHELL, Ian S. , SAMMOND, Douglas McCord , TANG, Tony P. , WALLACE, Eli M. , XU, Rui
Inventor： BANKA, Anna , BENCSIK, Josef R. , BLAKE, James F. , FONG, Kin Chiu , HENTEMANN, Martin F. , MITCHELL, Ian S. , SAMMOND, Douglas McCord , TANG, Tony P. , WALLACE, Eli M. , XU, Rui
IPC: C07D471/10 , C07D487/10 , A61K31/517 , A61K31/438 , A61P35/00
CPC classification number: C07D471/10 , C07D487/10
Abstract: The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitors and for the treatment of Akt-mediated diseases, for example, hyperproliferative diseases such as cancer.
Abstract translation: 本发明提供式（I）化合物，其包括互变异构体，拆分的对映异构体，拆分的非对映体，溶剂合物，代谢物，盐和药学上可接受的前药。 还提供了使用本发明化合物作为Akt蛋白激酶抑制剂和治疗Akt介导的疾病例如过度增殖性疾病如癌症的方法。
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公开(公告)号：WO2020131627A1
公开(公告)日：2020-06-25
申请号：PCT/US2019/066278
申请日：2019-12-13
Applicant: ARRAY BIOPHARMA INC.
Inventor： BLAKE, James F. , MORENO, David A. , REN, Li , TANG, Tony P. , WALLS, Shane M.
IPC: C07D471/04 , C07D519/00 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/4995 , A61P35/00
Abstract: Provided herein are compounds of the general Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which Ring A, Ring B, Ring C, R 1 , R 2 , L, Y, and W have the meanings given in the specification, which are inhibitors of FGFR1, FGFR2, FGFR3 and/or FGFR4 and are useful in the treatment and prevention of diseases which can be treated with an FGFR inhibitor, including diseases or disorders mediated by FGFR1, FGFR2, FGFR3 and/or FGFR4.
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Patent Agency Ranking6.发明申请2-ARYL- AND 2-HETEROARYL-SUBSTITUTED 2-PYRIDAZIN-3(2H)-ONE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES 审中-公开2-芳基 - 和2-杂芳基 - 取代的2-哒嗪-3（2H） - 酮化合物作为FGFR酪氨酸激酶的抑制剂
公开(公告)号：WO2017070708A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/058549
申请日：2016-10-24
Applicant: ARRAY BIOPHARMA, INC.
Inventor： ANDREWS, Steven W. , BLAKE, James F. , COOK, Adam , GUNAWARDANA, Indrani W. , HUNT, Kevin W. , METCALF, Andrew T. , MORENO, David , REN, Li , TANG, Tony P.
IPC: C07D401/14 , C07D403/14 , A61K31/444 , A61P35/00
CPC classification number: C07D403/14 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D413/14 , C12Q1/6886 , G01N33/574
Abstract: Provided herein are compounds of the general Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which X, R 1 , R 2 , R 3 , Ring A and z have the meanings given in the specification, which are inhibitors of FGFR1, FGFR2, FGFR3 and/or FGFR4 and are useful in the treatment and prevention of diseases which can be treated with an FGFR inhibitor, including diseases or disorders mediated by FGFR1, FGFR2, FGFR3 and/or FGFR4.
Abstract translation: 本文提供通式I的化合物及其立体异构体和药学上可接受的盐或溶剂化物，其中X，R 1，R 2， R 3和R 3具有在说明书中给出的含义，它们是FGFR1，FGFR2，FGFR3和/或FGFR4的抑制剂，并且可用于治疗和预防可以是 用FGFR抑制剂治疗，包括由FGFR1，FGFR2，FGFR3和/或FGFR4介导的疾病或病症。
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7.发明申请4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS 审中-公开4,6-取代的吡唑并[1,5-a]吡啶作为JANUS KINASE INHIBITORS
公开(公告)号：WO2016090285A1
公开(公告)日：2016-06-09
申请号：PCT/US2015/064062
申请日：2015-12-04
Applicant: ARRAY BIOPHARMA INC. , CELGENE CORPORATION
Inventor： ALLEN, Shelley , BOYS, Mark Laurence , CHICARELLI, Mark J. , FELL, Jay Bradford , FISCHER, John P. , GAUDINO, John , HICKEN, Erik James , HINKLIN, Ronald Jay , KRASER, Christopher F. , LAIRD, Ellen , ROBINSON, John E. , TANG, Tony P. , BURGESS, Laurence E. , RIEGER, Robert Andrew , PHENEGER, Jed , SATOH, Yoshitaka , LEFTHERIS, Katerina , RAHEJA, Raj K. , BENNETT, Brydon L.
IPC: C07D487/04 , A61K31/4985 , A61P29/00 , A61P37/00
CPC classification number: C07D487/04 , A61K31/4985 , A61K31/5377 , A61K45/06
Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R 1 , R 2 , R 3 and R 4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
Abstract translation: 式I化合物及其立体异构体及其药学上可接受的盐和溶剂化物，其中R1，R2，R3和R4具有说明书中给出的含义，是一种或多种JAK激酶的抑制剂，并且可用于治疗JAK激酶相关 疾病和病症，例如自身免疫性疾病，炎症性疾病，移植器官，组织和细胞的排斥，以及血液系统疾病和恶性肿瘤及其并发症。
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公开(公告)号：WO2013148851A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/034129
申请日：2013-03-27
Applicant: ARRAY BIOPHARMA INC. , GENENTECH, INC.
Inventor： HICKEN, Erik James , HUNT, Kevin W. , RODRIGUEZ, Martha E. , TANG, Tony P. , SIU, Michael
IPC: C07D513/10 , A61K31/429 , A61P25/28 , A61P25/00
CPC classification number: C07D498/10 , C07D513/10
Abstract: The invention provides novel tricyclic compounds of Formula (I) that inhibit β- secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.
Abstract translation: 本发明提供抑制APP的β-分泌酶切割的新颖的式（I）三环化合物，并且可用作治疗神经变性疾病的治疗剂。
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公开(公告)号：EP3694854A1
公开(公告)日：2020-08-19
申请号：EP18796243.6
申请日：2018-10-10
Applicant: Array Biopharma, Inc.
Inventor： METCALF, Andrew T. , FRY, David , MCFADDIN, Elizabeth A. , KOLAKOWSKI, Gabrielle R. , HAAS, Julia , TANG, Tony P. , JIANG, Yutong
IPC: C07D471/04 , A61P35/00 , A61K31/437
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公开(公告)号：EP4021444A1
公开(公告)日：2022-07-06
申请号：EP20859068.7
申请日：2020-08-27
Applicant: Mirati Therapeutics, Inc. , Array BioPharma Inc.
Inventor： WANG, Xiaolun , BURNS, Aaron Craig , CHRISTENSEN, James Gail , KETCHAM, John Michael , LAWSON, John David , MARX, Matthew Arnold , SMITH, Christopher Ronald , ALLEN, Shelley , BLAKE, James Francis , CHICARELLI, Mark Joseph , DAHLKE, Joshua Ryan , DAI, Donghua , FELL, Jay Bradford , FISCHER, John Peter , MEJIA, Macedonio J. , NEWHOUSE, Brad , NGUYEN, Phong , O'LEARY, Jacob Matthew , PAJK, Spencer , RODRIGUEZ, Martha E. , SAVECHENKOV, Pavel , TANG, Tony P. , VIGERS, Guy P. A. , ZHAO, Qian , KAHN, Dean Russell , GAUDINO, John , HILTON, Michael Christopher
IPC: A61K31/435 , A61K31/4375 , A61K31/517 , C07D471/00 , C07D471/02 , C07D471/04
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