公开(公告)号：WO2020055672A1

公开(公告)日：2020-03-19

申请号：PCT/US2019/049859

申请日：2019-09-06

Applicant: ARRAY BIOPHARMA INC.

Inventor： BLAKE, James F. ,  DAI, Donghua ,  HAAS, Julia ,  JIANG, Yutong ,  KAHN, Dean ,  KOLAKOWSKI, Gabrielle R. ,  MCFADDIN, Elizabeth A. ,  MCKENNEY, Megan L. ,  METCALF, Andrew T. ,  MORENO, David A. ,  PRIGARO, Brett ,  RAMANN, Ginelle A. ,  REN, Li ,  WALLS, Shane M. ,  ZHANG, Hailong

IPC: C07D487/14 ,  C07D487/22 ,  C07D498/14 ,  C07D498/22 ,  A61P35/00 ,  A61K31/551

Abstract: Provided herein are compounds of the Formula (I): (I) and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein R x , R y , W, X, Y, Z, Ring A and (AA) have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

公开(公告)号：WO2019143994A1

公开(公告)日：2019-07-25

申请号：PCT/US2019/014277

申请日：2019-01-18

Applicant: ARRAY BIOPHARMA INC.

Inventor： WALLS, Shane M. ,  REN, Li ,  RAMANN, Ginelle A. ,  MORENO, David A. ,  METCALF, Andrew T. ,  MCFADDIN, Elizabeth A. ,  KOLAKOWSKI, Gabrielle R. ,  BLAKE, James F. ,  DAI, Donghua ,  HAAS, Julia ,  JIANG, Yutong ,  KAHN, Dean

IPC: C07D471/04 ,  A61P35/00 ,  A61K31/437

Abstract: Provided herein are compounds of the Formula I: and tautomers and pharmaceutically acceptable salts and solvates thereof, wherein R 1 , R 2 and R 3 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

公开(公告)号：WO2019143977A1

公开(公告)日：2019-07-25

申请号：PCT/US2019/014248

申请日：2019-01-18

Applicant: ARRAY BIOPHARMA INC.

Inventor： BLAKE, James F. ,  DAI, Donghua ,  HAAS, Julia ,  JIANG, Yutong ,  KOLAKOWSKI, Gabrielle R. ,  MCFADDIN, Elizabeth A. ,  MCKENNEY, Megan L. ,  METCALF, Andrew T. ,  MORENO, David A. ,  PRIGARO, Brett ,  RAMANN, Ginelle A. ,  REN, Li

IPC: C07D487/04 ,  A61P35/00 ,  A61K31/519

CPC classification number: C07D487/04 ,  A61P35/00

Abstract: Provided herein are compounds of the Formula I: [INSERT FORMULA I] and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2 and Ry have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

公开(公告)号：WO2019113190A1

公开(公告)日：2019-06-13

申请号：PCT/US2018/064039

申请日：2018-12-05

Applicant: ARRAY BIOPHARMA INC.

Inventor： ALLEN, Shelley ,  BOYS, Mark Laurence ,  COOK, Adam ,  GAUDINO, John ,  HINKLIN, Ronald Jay ,  LAIRD, Ellen ,  MCNULTY, Oren T. ,  METCALF, Andrew T. ,  NEWHOUSE, Brad ,  ROBINSON, John E.

IPC: C07D471/04 ,  A61P35/00 ,  A61K31/437

Abstract: Provided herein are compounds of the Formula (I): and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein Ring A, X 1 , X 2 , X 3 , R 1 , R 2 and R 3 are as defined herein, which are inhibitors of one or more TAM kinases and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor.

公开(公告)号：WO2017070708A1

公开(公告)日：2017-04-27

申请号：PCT/US2016/058549

申请日：2016-10-24

Applicant: ARRAY BIOPHARMA, INC.

Inventor： ANDREWS, Steven W. ,  BLAKE, James F. ,  COOK, Adam ,  GUNAWARDANA, Indrani W. ,  HUNT, Kevin W. ,  METCALF, Andrew T. ,  MORENO, David ,  REN, Li ,  TANG, Tony P.

IPC: C07D401/14 ,  C07D403/14 ,  A61K31/444 ,  A61P35/00

CPC classification number: C07D403/14 ,  A61K31/501 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D413/14 ,  C12Q1/6886 ,  G01N33/574

Abstract: Provided herein are compounds of the general Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which X, R 1 , R 2 , R 3 , Ring A and z have the meanings given in the specification, which are inhibitors of FGFR1, FGFR2, FGFR3 and/or FGFR4 and are useful in the treatment and prevention of diseases which can be treated with an FGFR inhibitor, including diseases or disorders mediated by FGFR1, FGFR2, FGFR3 and/or FGFR4.

Abstract translation: 本文提供通式I的化合物及其立体异构体和药学上可接受的盐或溶剂化物，其中X，R 1，R 2， R 3和R 3具有在说明书中给出的含义，它们是FGFR1，FGFR2，FGFR3和/或FGFR4的抑制剂，并且可用于治疗和预防可以是 用FGFR抑制剂治疗，包括由FGFR1，FGFR2，FGFR3和/或FGFR4介导的疾病或病症。

公开(公告)号：EP3523301B1

公开(公告)日：2020-05-27

申请号：EP17787843.6

申请日：2017-10-10

Applicant: Array Biopharma Inc.

Inventor： ANDREWS, Steven W. ,  ARONOW, Sean ,  BLAKE, James F. ,  BRANDHUBER, Barbara J. ,  COOK, Adam ,  HAAS, Julia ,  JIANG, Yutong ,  KOLAKOWSKI, Gabrielle R. ,  MCFADDIN, Elizabeth A. ,  MCKENNEY, Megan L. ,  MCNULTY, Oren T. ,  METCALF, Andrew T. ,  MORENO, David A. ,  TANG, Tony P. ,  REN, Li

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

公开(公告)号：EP3849986A1

公开(公告)日：2021-07-21

申请号：EP19773595.4

申请日：2019-09-06

Applicant: Array Biopharma, Inc.

Inventor： BLAKE, James F. ,  DAI, Donghua ,  HAAS, Julia ,  JIANG, Yutong ,  KAHN, Dean ,  KOLAKOWSKI, Gabrielle R. ,  MCFADDIN, Elizabeth A. ,  MCKENNEY, Megan L. ,  METCALF, Andrew T. ,  MORENO, David A. ,  PRIGARO, Brett ,  RAMANN, Ginelle A. ,  REN, Li ,  WALLS, Shane M. ,  ZHANG, Hailong

IPC: C07D487/14 ,  C07D487/22 ,  C07D498/14 ,  C07D498/22 ,  A61P35/00 ,  A61K31/551

公开(公告)号：EP3740486A1

公开(公告)日：2020-11-25

申请号：EP19703912.6

申请日：2019-01-18

Applicant: Array Biopharma, Inc.

Inventor： WALLS, Shane M. ,  REN, Li ,  RAMANN, Ginelle A. ,  MORENO, David A. ,  METCALF, Andrew T. ,  MCFADDIN, Elizabeth A. ,  KOLAKOWSKI, Gabrielle R. ,  BLAKE, James F. ,  DAI, Donghua ,  HAAS, Julia ,  JIANG, Yutong ,  KAHN, Dean

IPC: C07D471/04 ,  A61P35/00 ,  A61K31/437

公开(公告)号：EP3740491A1

公开(公告)日：2020-11-25

申请号：EP19703907.6

申请日：2019-01-18

Applicant: Array Biopharma, Inc.

Inventor： BLAKE, James F. ,  DAI, Donghua ,  HAAS, Julia ,  JIANG, Yutong ,  KOLAKOWSKI, Gabrielle R. ,  MCFADDIN, Elizabeth A. ,  MCKENNEY, Megan L. ,  METCALF, Andrew T. ,  MORENO, David A. ,  PRIGARO, Brett ,  RAMANN, Ginelle A. ,  REN, Li

IPC: C07D487/04 ,  A61P35/00 ,  A61K31/519

公开(公告)号：EP3694853A1

公开(公告)日：2020-08-19

申请号：EP18796238.6

申请日：2018-10-10

Applicant: Array BioPharma Inc. ,  Loxo Oncology, Inc.

Inventor： EARY, Charles Todd ,  SPENCER, Stacey ,  CRANE, Zack ,  CHANDO, Katelyn ,  ASSELIN, Sylvie ,  LIU, Weidong ,  WELCH, Mike ,  COOK, Adam ,  KOLAKOWSKI, Gabrielle R. ,  METCALF, Andrew T. ,  MORENO, David A. ,  TANG, Tony P.

IPC: C07D471/04 ,  C07D519/00