公开(公告)号：EP3523301B1

公开(公告)日：2020-05-27

申请号：EP17787843.6

申请日：2017-10-10

Applicant: Array Biopharma Inc.

Inventor： ANDREWS, Steven W. ,  ARONOW, Sean ,  BLAKE, James F. ,  BRANDHUBER, Barbara J. ,  COOK, Adam ,  HAAS, Julia ,  JIANG, Yutong ,  KOLAKOWSKI, Gabrielle R. ,  MCFADDIN, Elizabeth A. ,  MCKENNEY, Megan L. ,  MCNULTY, Oren T. ,  METCALF, Andrew T. ,  MORENO, David A. ,  TANG, Tony P. ,  REN, Li

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

公开(公告)号：EP3523301A1

公开(公告)日：2019-08-14

申请号：EP17787843.6

申请日：2017-10-10

Applicant: Array Biopharma Inc.

Inventor： ANDREWS, Steven W. ,  ARONOW, Sean ,  BLAKE, James F. ,  BRANDHUBER, Barbara J. ,  COOK, Adam ,  HAAS, Julia ,  JIANG, Yutong ,  KOLAKOWSKI, Gabrielle R. ,  MCFADDIN, Elizabeth A. ,  MCKENNEY, Megan L. ,  MCNULTY, Oren T. ,  METCALF, Andrew T. ,  MORENO, David A. ,  TANG, Tony P. ,  REN, Li

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

公开(公告)号：EP3523302A1

公开(公告)日：2019-08-14

申请号：EP17787844.4

申请日：2017-10-10

Applicant: Array Biopharma, Inc. ,  McFaddin, Elizabeth A. ,  McKenney, Megan L. ,  McNulty, Oren T. ,  Metcalf, Andrew T. ,  Moreno, David A. ,  Ramann, Ginelle A. ,  Tang, Tony P. ,  Ren, Li ,  Walls, Shane M.

Inventor： ANDREWS, Steven W. ,  ARONOW, Sean ,  BLAKE, James F. ,  BRANDENHUBER, Barbara J. ,  COLLIER, James ,  COOK, Adam ,  HAAS, Julia ,  JIANG, Yutong ,  KOLAKOWSKI, Gabrielle R.

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00