公开(公告)号：WO2019143977A1

公开(公告)日：2019-07-25

申请号：PCT/US2019/014248

申请日：2019-01-18

Applicant: ARRAY BIOPHARMA INC.

Inventor： BLAKE, James F. ,  DAI, Donghua ,  HAAS, Julia ,  JIANG, Yutong ,  KOLAKOWSKI, Gabrielle R. ,  MCFADDIN, Elizabeth A. ,  MCKENNEY, Megan L. ,  METCALF, Andrew T. ,  MORENO, David A. ,  PRIGARO, Brett ,  RAMANN, Ginelle A. ,  REN, Li

IPC: C07D487/04 ,  A61P35/00 ,  A61K31/519

CPC classification number: C07D487/04 ,  A61P35/00

Abstract: Provided herein are compounds of the Formula I: [INSERT FORMULA I] and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2 and Ry have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

公开(公告)号：WO2020055672A1

公开(公告)日：2020-03-19

申请号：PCT/US2019/049859

申请日：2019-09-06

Applicant: ARRAY BIOPHARMA INC.

Inventor： BLAKE, James F. ,  DAI, Donghua ,  HAAS, Julia ,  JIANG, Yutong ,  KAHN, Dean ,  KOLAKOWSKI, Gabrielle R. ,  MCFADDIN, Elizabeth A. ,  MCKENNEY, Megan L. ,  METCALF, Andrew T. ,  MORENO, David A. ,  PRIGARO, Brett ,  RAMANN, Ginelle A. ,  REN, Li ,  WALLS, Shane M. ,  ZHANG, Hailong

IPC: C07D487/14 ,  C07D487/22 ,  C07D498/14 ,  C07D498/22 ,  A61P35/00 ,  A61K31/551

Abstract: Provided herein are compounds of the Formula (I): (I) and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein R x , R y , W, X, Y, Z, Ring A and (AA) have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

公开(公告)号：WO2019143994A1

公开(公告)日：2019-07-25

申请号：PCT/US2019/014277

申请日：2019-01-18

Applicant: ARRAY BIOPHARMA INC.

Inventor： WALLS, Shane M. ,  REN, Li ,  RAMANN, Ginelle A. ,  MORENO, David A. ,  METCALF, Andrew T. ,  MCFADDIN, Elizabeth A. ,  KOLAKOWSKI, Gabrielle R. ,  BLAKE, James F. ,  DAI, Donghua ,  HAAS, Julia ,  JIANG, Yutong ,  KAHN, Dean

IPC: C07D471/04 ,  A61P35/00 ,  A61K31/437

Abstract: Provided herein are compounds of the Formula I: and tautomers and pharmaceutically acceptable salts and solvates thereof, wherein R 1 , R 2 and R 3 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

公开(公告)号：EP3523301A1

公开(公告)日：2019-08-14

申请号：EP17787843.6

申请日：2017-10-10

Applicant: Array Biopharma Inc.

Inventor： ANDREWS, Steven W. ,  ARONOW, Sean ,  BLAKE, James F. ,  BRANDHUBER, Barbara J. ,  COOK, Adam ,  HAAS, Julia ,  JIANG, Yutong ,  KOLAKOWSKI, Gabrielle R. ,  MCFADDIN, Elizabeth A. ,  MCKENNEY, Megan L. ,  MCNULTY, Oren T. ,  METCALF, Andrew T. ,  MORENO, David A. ,  TANG, Tony P. ,  REN, Li

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

公开(公告)号：EP3523301B1

公开(公告)日：2020-05-27

申请号：EP17787843.6

申请日：2017-10-10

Applicant: Array Biopharma Inc.

Inventor： ANDREWS, Steven W. ,  ARONOW, Sean ,  BLAKE, James F. ,  BRANDHUBER, Barbara J. ,  COOK, Adam ,  HAAS, Julia ,  JIANG, Yutong ,  KOLAKOWSKI, Gabrielle R. ,  MCFADDIN, Elizabeth A. ,  MCKENNEY, Megan L. ,  MCNULTY, Oren T. ,  METCALF, Andrew T. ,  MORENO, David A. ,  TANG, Tony P. ,  REN, Li

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

公开(公告)号：EP3849986A1

公开(公告)日：2021-07-21

申请号：EP19773595.4

申请日：2019-09-06

Applicant: Array Biopharma, Inc.

Inventor： BLAKE, James F. ,  DAI, Donghua ,  HAAS, Julia ,  JIANG, Yutong ,  KAHN, Dean ,  KOLAKOWSKI, Gabrielle R. ,  MCFADDIN, Elizabeth A. ,  MCKENNEY, Megan L. ,  METCALF, Andrew T. ,  MORENO, David A. ,  PRIGARO, Brett ,  RAMANN, Ginelle A. ,  REN, Li ,  WALLS, Shane M. ,  ZHANG, Hailong

IPC: C07D487/14 ,  C07D487/22 ,  C07D498/14 ,  C07D498/22 ,  A61P35/00 ,  A61K31/551

公开(公告)号：EP3740486A1

公开(公告)日：2020-11-25

申请号：EP19703912.6

申请日：2019-01-18

Applicant: Array Biopharma, Inc.

Inventor： WALLS, Shane M. ,  REN, Li ,  RAMANN, Ginelle A. ,  MORENO, David A. ,  METCALF, Andrew T. ,  MCFADDIN, Elizabeth A. ,  KOLAKOWSKI, Gabrielle R. ,  BLAKE, James F. ,  DAI, Donghua ,  HAAS, Julia ,  JIANG, Yutong ,  KAHN, Dean

IPC: C07D471/04 ,  A61P35/00 ,  A61K31/437

公开(公告)号：EP3740491A1

公开(公告)日：2020-11-25

申请号：EP19703907.6

申请日：2019-01-18

Applicant: Array Biopharma, Inc.

Inventor： BLAKE, James F. ,  DAI, Donghua ,  HAAS, Julia ,  JIANG, Yutong ,  KOLAKOWSKI, Gabrielle R. ,  MCFADDIN, Elizabeth A. ,  MCKENNEY, Megan L. ,  METCALF, Andrew T. ,  MORENO, David A. ,  PRIGARO, Brett ,  RAMANN, Ginelle A. ,  REN, Li

IPC: C07D487/04 ,  A61P35/00 ,  A61K31/519

公开(公告)号：EP3694854A1

公开(公告)日：2020-08-19

申请号：EP18796243.6

申请日：2018-10-10

Applicant: Array Biopharma, Inc.

Inventor： METCALF, Andrew T. ,  FRY, David ,  MCFADDIN, Elizabeth A. ,  KOLAKOWSKI, Gabrielle R. ,  HAAS, Julia ,  TANG, Tony P. ,  JIANG, Yutong

IPC: C07D471/04 ,  A61P35/00 ,  A61K31/437