公开(公告)号：BG105640A

公开(公告)日：2003-01-31

申请号：BG10564001

申请日：2001-06-22

Applicant: BALKANFARMA DUPNITSA AD

Inventor： STANEVA TINKA D ,  KAFEDZHIJSKI STEFAN K ,  NACHEVA ELIZABETA B ,  PARALANOVA DANIELA I ,  STANEV STANCHO R ,  KATSARSKI DIMITAR E

IPC: C07C255/49

Abstract: The method is used in the pharmaceutical industry for the production of 4-hydroxy-3-iodo-5-nitrobenzonitrile, known by its generic name of Nitroxynil, which is used in the veterinary pharmaceutical practice for the treatment of helminthic infections. The compound has high yield and purity and is produced by the method of nitration of 4-hydroxybenzonitrile with water solution of sodium or ammonium nitrate, in saline-acidic medium at 80 degrees C and continuous agitation. The 4-hydroxy-5-netrobenzonitrile produced is iodized at 80 to 110 degrees C, after which the reaction mixture is cooled to 10-15 degrees C. The precipitation of 4-hydroxy-3-iodo-5-benzonitrile is filtered, rinsed in water, re-crystallized in ethanol and is dried. 3 claims