公开(公告)号：BG63360B1

公开(公告)日：2001-11-30

申请号：BG10361199

申请日：1999-07-28

Applicant: BALKANFARMA DUPNITSA AD

Inventor： PARALANOVA DANIELA I ,  STANEVA TINKA D ,  KAFEDZHIJSKI STEFAN K

IPC: A61K31/00 ,  A61K31/14 ,  C07C209/12 ,  C07C211/63

Abstract: The method finds application in the chemical industry. The cetyl-trimethyl ammonium bromide is used as a disinfectant in the human and veterinary medicine, as birth control means, as well as in testing of foods in the food industry, By the method the cetyl-trimethyl ammonium bromide is produced with high yield and purity in reaction with cetyl bromide, produced in the bromation of cetyl alcohol with dual residue of hydrogen bromide in sulphur-acid medium with alcohol solution of trimethylamine. After the end of the process the alcohol is distilled under vacuum, the residue is cooled and mixed with acetone with intensive agitation. The mixture produced is filtered, and the separated sediment of the cetyl-trimethyl ammonium bromide is dried. 1 claim

公开(公告)号：BG103611A

公开(公告)日：2001-02-28

申请号：BG10361199

申请日：1999-07-28

Applicant: BALKANFARMA DUPNITSA AD

Inventor： PARALANOVA DANIELA I ,  STANEVA TINKA D ,  KAFEDZHIJSKI STEFAN K

IPC: A61K31/00 ,  A61K31/14 ,  C07C209/12 ,  C07C211/63

Abstract: The invention relates to a method for the synthesis of cetyl-trimethyl ammonium bromide with the formula The compound has strong bacterial effect and finds wide application in hygiene, birth control and foodstuffs testing for the content of dyestuffs. The cetyl-trimethyl ammonium bromide is produced by the reaction between cetylbromide and trimethylamine in alcohol medium with an yield of about 90 %. Each of the initial reagents is being produced at a high yield (85 %) and purity (98 %) and is being used for the synthesis of the end compound. The cetylbromide is produced from cetyl alcohol and hydrogen bromide, and the trimethylamine from paraformaldehyde and ammonium bromide. The methods for the synthesis of the intermediate products and the end compound are industrially applicable. 3 claims

公开(公告)号：BG105640A

公开(公告)日：2003-01-31

申请号：BG10564001

申请日：2001-06-22

Applicant: BALKANFARMA DUPNITSA AD

Inventor： STANEVA TINKA D ,  KAFEDZHIJSKI STEFAN K ,  NACHEVA ELIZABETA B ,  PARALANOVA DANIELA I ,  STANEV STANCHO R ,  KATSARSKI DIMITAR E

IPC: C07C255/49

Abstract: The method is used in the pharmaceutical industry for the production of 4-hydroxy-3-iodo-5-nitrobenzonitrile, known by its generic name of Nitroxynil, which is used in the veterinary pharmaceutical practice for the treatment of helminthic infections. The compound has high yield and purity and is produced by the method of nitration of 4-hydroxybenzonitrile with water solution of sodium or ammonium nitrate, in saline-acidic medium at 80 degrees C and continuous agitation. The 4-hydroxy-5-netrobenzonitrile produced is iodized at 80 to 110 degrees C, after which the reaction mixture is cooled to 10-15 degrees C. The precipitation of 4-hydroxy-3-iodo-5-benzonitrile is filtered, rinsed in water, re-crystallized in ethanol and is dried. 3 claims