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    Process for the preparation of 1,4-diazabicyclo[2.2.2]octanes
    2.
    发明专利
    Process for the preparation of 1,4-diazabicyclo[2.2.2]octanes 未知

    公开(公告)号：DE3634258A1

    公开(公告)日：1988-04-21

    申请号：DE3634258

    申请日：1986-10-08

    Applicant: BASF AG

    Inventor： HOELDERICH WOLFGANG DR ,  SCHNEIDER KURT DR ,  BEST WALTER DR

    IPC: C07D487/08 ,  B01J27/18

    Abstract: The invention relates to a process for the preparation of 1,4-diazabicyclo[2.2.2]octane and C-substituted 1,4-diazabicyclo[2.2.2]octanes of the formula (I) in which R and R can denote hydrogen radicals, alkyl radicals having from 1 to 4 C atoms or alkenyl radicals having from 1 to 4 C atoms, by reacting heterocyclic amines of the formula (II) in which R and R have the abovementioned meaning and R denotes hydrogen, hydroxyethyl or aminoethyl radicals and X denotes hydroxyl, amino, hydroxyethyl or aminoethyl radicals, in the presence of zirconium phosphates as catalysts. Examples of preferred starting materials are monohydroxyethylpiperazine and/or dihydroxyethylpiperazine.

    Process for the preparation of 1,4-diazabicyclo[2.2.2]octanes
    3.
    发明专利
    Process for the preparation of 1,4-diazabicyclo[2.2.2]octanes 未知

    公开(公告)号：DE3634257A1

    公开(公告)日：1988-04-21

    申请号：DE3634257

    申请日：1986-10-08

    Applicant: BASF AG

    Inventor： HOELDERICH WOLFGANG DR ,  SCHNEIDER KURT DR ,  BEST WALTER DR

    IPC: C07D487/08 ,  B01J29/04

    Abstract: The invention relates to a process for the preparation of 1,4-diazabicyclo[2.2.2]octane and C-substituted 1,4-diazabicyclo[2.2.2]octanes of the formula (I) in which R and R can denote hydrogen radicals, alkyl radicals having from 1 to 4 C atoms or alkenyl radicals having from 1 to 4 C atoms, by reacting heterocyclic amines of the formula (II) in which R and R have the abovementioned meaning and R denotes hydrogen, hydroxyethyl or aminoethyl radicals and X denotes hydroxyl, amino, hydroxyethyl or aminoethyl radicals, in the presence of L-zeolites as catalysts.

    Process for the preparation of 1,4-diazabicyclo[2.2.2]octanes
    7.
    发明专利
    Process for the preparation of 1,4-diazabicyclo[2.2.2]octanes 未知

    公开(公告)号：DE3634260A1

    公开(公告)日：1988-04-21

    申请号：DE3634260

    申请日：1986-10-08

    Applicant: BASF AG

    Inventor： HOELDERICH WOLFGANG DR ,  SCHNEIDER KURT DR ,  LERMER HELMUT DR ,  BEST WALTER DR

    IPC: C07D487/08 ,  B01J27/14 ,  B01J27/18

    Abstract: The invention relates to a process for the preparation of 1,4-diazabicyclo[2.2.2]octane and C-substituted 1,4-diazabicyclo[2.2.2]octanes of the formula (I) in which R and R can denote hydrogen radicals, alkyl radicals having from 1 to 4 C atoms or alkenyl radicals having from 1 to 4 C atoms, by reacting heterocyclic amines of the formula (II) in which R and R have the abovementioned meaning and R denotes hydrogen, hydroxyethyl or aminoethyl radicals and X denotes hydroxyl, amino, hydroxyethyl or aminoethyl radicals, in the presence of phosphates which have a zeolite structure as catalysts.

    9.
    发明专利
    未知

    公开(公告)号：DE3777743D1

    公开(公告)日：1992-04-30

    申请号：DE3777743

    申请日：1987-10-05

    Applicant: BASF AG

    Inventor： HOELDERICH WOLFGANG DR ,  SCHNEIDER KURT DR ,  LERMER HELMUT DR ,  BEST WALTER DR

    IPC: C07D487/08

    Abstract: Opt. substd. 1,4-diazabicyclo(2,2,2)-octanes of formula (I) in which R1 and R2 = H, 1-4C alkyl or 1-4 C alkylene, are prepd. by conversion of heterocyclic amines of formula (II) in which R1 and R2 are as above, R3 = H, hydroxy or aminoethyl and X = hydroxyl, amino, hydroxy or aminoethyl gp., in the presence of L-zeolites, phosphates with a zeolite structure, or Zr phosphates as catalyst. Zeolites are used as catalyst in conversion of heterocyclic amines (II) into 1,4-diazabicyclo(2,2,2)-octanes.

    10.
    发明专利
    未知

    公开(公告)号：DE3773535D1

    公开(公告)日：1991-11-14

    申请号：DE3773535

    申请日：1987-05-16

    Applicant: BASF AG

    Inventor： ECKHARDT HEINZ DR ,  GRAMLICH WALTER DR ,  BEST WALTER DR ,  HALBRITTER KLAUS DR

    IPC: B01J27/10 ,  B01J27/18 ,  B01J27/232 ,  B01J31/02 ,  C07B61/00 ,  C07D307/32 ,  C07D307/33 ,  C07D315/00

    Abstract: Prodn. of gamma-butyrolactone derivs. of formula (I) comprises reacting alkylene oxide (II) and acylacetate ester (III) in the presence of 0.001-0.1 mole per mole (II) of a catalyst (A) at 20-200 deg.C and 1-50 bars. (A) is an alkali, ammonium (pref. quat. ammonium) or phosphonium halide, alkali phosphate or alkali carbonate. (R1 = H or 1-4C alkyl (opt. substd. by lower alkoxy or acyloxy); R2 = 1-2C alkyl (opt. substd. by a functional gp. such as lower alkoxy, acyloxy, amido, OH, aryl or halo) or aryl; R3 and R4 = 1-6C alkyl or aryl, and R4 can also be H; R5 = H or R2). A mixt. of solvent, catalyst (esp. 0.003-0.5 mole per mole (II)) and (III) is pref. treated with (II) over 1-10 hr. at reaction temp. To improve yields, a small amt. (0.1-0.5 mole per mole (III)) of strong base is added after reaction, and then this neutralised with inorganic acid.

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