公开(公告)号：DE4446025A1

公开(公告)日：1996-06-27

申请号：DE4446025

申请日：1994-12-22

Applicant: BASF AG

Inventor： KANDZIA CHRISTOF DR ,  HENNINGSEN MICHAEL DR ,  DOYE SVEN DR

IPC: C07D241/24 ,  A61K31/495 ,  A61P31/12 ,  C07D213/38 ,  C07D241/06 ,  C07D401/06 ,  C07D241/04

Abstract: Disclosed are 2-carbamoyl-1,4,5,6-tetrahydropyrazines of general formula (I), wherein R , R and R are the same or different and in each case stand for a straight-chain or branched C1-C8 alkyl group, a C5-C6 cycloalkyl group, a C6-C7 methylene cycloalkyl group, a C6-C10 aryl group or a C7-C12 aralkyl group, or wherein the radicals R and R are connected and together with the exocyclic, noncabonylic carbon atom C form a 5 to 6-membered cycloaliphatic ring and R is as above, or wherein R is hydrogen and R and R are the same or different and are as above. Disclosed also is a method for their preparation and their use.

公开(公告)号：DE19507463A1

公开(公告)日：1996-09-05

申请号：DE19507463

申请日：1995-03-03

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL DR ,  KANDZIA CHRISTOF DR ,  DOYE SVEN DR

IPC: C07D241/06 ,  B01J23/04 ,  C07B61/00 ,  C07C253/00 ,  C07C253/08 ,  C07C255/30 ,  C07C303/02 ,  C07C303/32 ,  C07C309/08 ,  C07C309/14

Abstract: An improved process is disclosed for preparing alpha , beta -diaminoacrylnitriles having the general formula (I) R R NC(R )=C(NR R )CN, in which R stands for hydrogen, substituted or non-substituted aliphatic residues with 1 to 30 carbon atoms, cycloaliphatic residues with 3 to 8 ring members or aromatic, heteroaromatic or araliphatic residues with 7 to 12 carbon atoms; R and R are the same or different and stand for hydrogen or an aliphatic residue with 1 to 15 carbon atoms, a cycloaliphatic residue with 3 to 8 ring members or an aromatic, heterocyclic or araliphatic residue with 7 to 12 carbon atoms, or residues R and R may be bound together into a 5- or 6-membered ring that may also carry another heteroatom. In this process, component (A) is reacted with components (B), (C) and (D) in any desired order. (A) is an alpha -dicarbonyl compound having the general formula R COCHO, in which R has the above-said meaning, or a reactive derivative of said carbonyl compound. (B) is a salt of sulphurous acid, sulphur dioxide or a sulphur dioxide-releasing reactive. (C) is an amine having the general formula HNR R or an aliphatic diamine having the general formula R HN-(CH2)n-NHR , in which the alkylene chain may also bear an R substituent having, like R , the above-said meaning and n equals 2 or 3, or derivatives that are converted into amine or diamine in reaction conditions. (D) is liquid or gaseous hydrocyanic acid or a hydrocyanic acid-releasing reactive. The reaction is carried out with at least 3.5 equivalent alkali compounds per mole of component A. The most part of the alkaline compound consists of potassium compounds and at least one alkali equivalent is added as a free alkaline lye, provided that the proportion of potassium equivalents be sufficiently high for all inorganic salts to remain practically completely in solution at the end of the reaction.

公开(公告)号：DE19620494A1

公开(公告)日：1997-11-27

申请号：DE19620494

申请日：1996-05-21

Applicant: BASF AG

Inventor： DOYE SVEN DR ,  BOMM VOLKER DR ,  FISCHER MARTIN DR

IPC: C07D241/06 ,  C07D401/06 ,  C07D241/04

Abstract: 1-(alkanoyl halide)-2-carboxamido-1,4,5,6-tetrahydropyrazines of general formula (I), in which R , R and R are the same or different and represent a straight or branched-chain C1 to C8 alkyl group, a C5 to C6 cycloalkyl group, a C6 to C7 methylene cycloalkyl group, a C6 to C10 aryl group or a C7 to C12 aralkyl group or in which the radicals R and R are bonded together and jointly with the exocyclic non-carbonylic carbon atom C form a 5 to 6-component cycloaliphatic ring and R has the above meaning or in which R is hydrogen and R and R are the same or different and have the above meaning, R is a C1 to C19 alkyl halide group containing one or more identical or different halogen atoms selected from fluorine and/or chlorine as the halogen substituent and in which R is hydrogen or a tertiary butyl oxycarbonyl or a benzyl oxycarbonyl group. Also described is a process for production of said compounds and the use thereof.