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公开(公告)号：HU221596B
公开(公告)日：2002-11-28
申请号：HU9603189
申请日：1995-05-09
Applicant: BASF AG
Inventor： DR DE POTZOLLI BERND , DR KARL ULRICH , DR MUELLER STEFAN
IPC: C07B61/00 , C07C227/18 , C07C229/12 , C07C269/06 , C07C271/22 , C07C323/59
Abstract: A process for preparing N-protected N-alkylated amino acids of the formula I:in which the substituents have the meanings stated in the description, comprises mixing a compound of the formula IIwith a solution of potassium tert-butanolate in a non-protic organic solvent, and subsequently adding a C1-2-alkyl halide.
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公开(公告)号：HU220875B1
公开(公告)日：2002-06-29
申请号：HU9603067
申请日：1995-04-26
Applicant: BASF AG
Inventor： DR AMBERG WILHELM , DR BERNARD HARALD , DR BUSCHMANN ERNST , DR DE POTZOLLI BERND , DR HAUPT ANDREAS , DR JANITSCHKE LOTHAR , DR JANSSEN BERND , DR KARL ULRICH , DR KLING ANDREAS , DR MUELLER STEFAN , DR RITTER KURT , DR THYES MARCO , DR ZIERKE THOMAS
Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.
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公开(公告)号：HU220862B1
公开(公告)日：2002-06-29
申请号：HU9603068
申请日：1995-04-26
Applicant: BASF AG
Inventor： DR AMBERG WILHELM , DR BERNARD HARALD , DR BUSCHMANN ERNST , DR DE POTZOLLI BERND , DR HAUPT ANDREAS , DR JANITSCHKE LOTHAR , DR JANSSEN BERND , DR KARL ULRICH , DR KLING ANDREAS , DR MUELLER STEFAN , DR RITTER KURT , DR THYES MARCO , DR ZIERKE THOMAS
Abstract: Compounds of the formulawhere R1, R2, R3 and R4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.
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