公开(公告)号：HU0002902A2

公开(公告)日：2001-02-28

申请号：HU0002902

申请日：1998-05-29

Applicant: BASF AG

Inventor： DR BACH ALFRED ,  DULLWEBER UTA ,  DR EMLING FRANZ ,  GARCIA-LADONA FRANCISCO-JAVIER ,  STARCK DOROTHEA ,  DR STEINER GERD ,  DR TESCHENDORF HANS-JUERGEN ,  DR WICKE KARSTEN

IPC: A61K31/495 ,  A61K31/519 ,  A61P25/00 ,  A61P25/24 ,  A61P43/00 ,  C07D495/04

Abstract: PCT No. PCT/EP98/03230 Sec. 371 Date Dec. 6, 1999 Sec. 102(e) Date Dec. 6, 1999 PCT Filed May 29, 1998 PCT Pub. No. WO98/56792 PCT Pub. Date Dec. 17, 19983-Substituted 3,4-dihydrothieno[2,3-d]pyrimidine derivatives of the formula I where R1 and R2 are a hydrogen atom or a C1-C4-alkyl group, R3 is a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which is unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, trifluoromethyl, trifluoromethoxy, hydroxyl, C1-C4-alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and which may be fused to a benzene nucleus which may be unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, hydroxyl, trifluoromethyl, C1-C4-alkoxy, amino, cyano or nitro groups, and may contain 1 nitrogen atom, or to a 5- or 6-membered ring, which may contain 1-2 oxygen atoms, A is NH or an oxygen atom, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z is a nitrogen atom, carbon atom or CH, it being possible for the linkage between Y and Z also to be a double bond, and n is 2, 3 or 4, and the physiologically tolerated salts thereof.

公开(公告)号：HU0103358A2

公开(公告)日：2002-05-29

申请号：HU0103358

申请日：1999-07-20

Applicant: BASF AG

Inventor： DR HOEGER THOMAS ,  JUCHELKA FRIEDER ,  DR STEINER GERD ,  DR TESCHENDORF HANS-JUERGEN ,  DR UNGER LILIANE

IPC: A61K31/425 ,  A61K31/428 ,  A61P25/00 ,  C07D417/06

Abstract: Compounds of the formula I:in which R1, R2, R3 and R4 have the meanings stated in the description, are described.The novel compounds are suitable for controlling diseases.

公开(公告)号：HU0104416A2

公开(公告)日：2002-04-29

申请号：HU0104416

申请日：1999-11-12

Applicant: BASF AG

Inventor： GROSS GERHARD ,  DR MUNSCHAUER RAINER ,  DR STEINER GERD ,  DR TESCHENDORF HANS-JUERGEN ,  TRAUT MARTIN ,  DR UNGER LILIANE

IPC: C07D403/06 ,  A61K31/403 ,  A61K31/4045 ,  A61K31/407 ,  A61K31/4184 ,  A61K31/424 ,  A61K31/427 ,  A61K31/4709 ,  A61K31/505 ,  A61K31/506 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/542 ,  A61P25/00 ,  A61P25/28 ,  A61P25/30 ,  A61P25/36 ,  C07D209/52 ,  C07D407/12 ,  C07D409/12 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04

Abstract: The invention relates to the use of N-substituted 3-azabicycloalkane derivatives of formula (I), wherein B, R , R and n have the meanings given in the description, for combating diseases of addiction and other diseases of the central nervous system.

公开(公告)号：HU0003758A2

公开(公告)日：2001-10-28

申请号：HU0003758

申请日：1998-10-05

Applicant: BASF AG

Inventor： DR BACH ALFRED ,  DULLWEBER UTA ,  DR EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  DR LUBISCH WILFRIED ,  STARCK DOROTHEA ,  DR STEINER GERD ,  DR TESCHENDORF HANS-JUERGEN ,  DR WICKE KARSTEN

IPC: A61K31/428 ,  A61P25/24 ,  A61P43/00 ,  C07D275/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

Abstract: where the substituents have the meanings indicated in the description, their preparation and use as serotonin antagonists.

公开(公告)号：HU0200520A2

公开(公告)日：2002-07-29

申请号：HU0200520

申请日：1999-12-22

Applicant: BASF AG

Inventor： DR EMLING FRANZ ,  GARCIA-LADONA FRANCISCO JAVIER ,  DR HOFMANN HANS-PETER ,  HOLZENKAMP UTA ,  LUBISCH WILFRIED ,  SCHELLHAAS KURT ,  STARCK DOROTHEA ,  DR STEINER GERD ,  DR SZABO LASZLO ,  DR UNGER LILIANE

IPC: C07D275/06 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/55 ,  A61K31/551 ,  A61P9/10 ,  A61P25/28 ,  C07D401/12 ,  C07D417/12 ,  C07D471/04

Abstract: The invention relates to the utilisation of compounds of formula (I) wherein the substituents have the meanings given in the description. The invention also relates to the salts thereof comprising pharmacologically compatible acids for producing medicaments for the prophylaxis and therapy of cerebral ischaemia and strokes.

公开(公告)号：HU0103099A2

公开(公告)日：2002-03-28

申请号：HU0103099

申请日：1999-07-20

Applicant: BASF AG

Inventor： HOEGER THOMAS ,  JUCHELKA FRIEDER ,  DR STEINER GERD ,  TESCHENDORF HANS-JUERGEN ,  DR UNGER LILIANE

IPC: A61K31/4184 ,  A61P25/20 ,  A61P25/24 ,  A61P25/30 ,  C07D403/06

Abstract: The invention relates to compounds of formula (1), wherein R , R and R have the meaning cited in the description. The novel substances are suitable for use in disease control.

公开(公告)号：HU0002736A2

公开(公告)日：2001-02-28

申请号：HU0002736

申请日：1998-05-29

Applicant: BASF AG

Inventor： DR BACH ALFRED ,  DULLWEBER UTA ,  DR EMLING FRANZ ,  GARCIA-LADONA FRANCISCO-JAVIER ,  STARCK DOROTHEA ,  DR STEINER GERD ,  DR TESCHENDORF HANS-JUERGEN ,  DR WICKE KARSTEN

IPC: A61K31/505 ,  A61K31/519 ,  A61P25/00 ,  A61P25/24 ,  A61P43/00 ,  C07D495/14

Abstract: PCT No. PCT/EP98/03231 Sec. 371 Date Dec. 8, 1999 Sec. 102(e) Date Dec. 8, 1999 PCT Filed May 29, 1998 PCT Pub. No. WO98/56793 PCT Pub. Date Dec. 17, 19983-Substituted 3,4,5,6,7,8-hexahydropyrido [3',4':4,5]-thieno[2,3-d]pyrimidine derivatives of the formula I where R1 is a hydrogen atom, a C1-C4-alkyl group, an acetyl group, a phenylalkyl C1-C4 radical, the aromatic system being unsubstituted or substituted by halogen, C1-C4-alkyl, trifluoromethyl, hydroxyl, C1-C4-alkoxy, amino, cyano or nitro groups, or is a phenylalkanone radical, it being possible for the phenyl group to be substituted by halogen, R2 is a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which is unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, trifluoromethyl, trifluoromethoxy, hydroxyl, C1-C4-alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and which may be fused to a benzene nucleus which can be unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, hydroxyl, trifluoromethyl, C1-C4-alkoxy, amino, cyano or nitro groups and may contain 1 nitrogen atom, or to a 5- or 6-membered ring which may contain 1-2 oxygen atoms, A is NH or an oxygen atom, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z is a nitrogen atom, carbon atom or CH, it also being possible for the linkage between Y and Z to be a double bond, and n is 2, 3 or 4, and the physiologically tolerated salts thereof.