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    3-SUBSTITUTED PYRIDO [3',4':4,5]THIENO[2,3-D]PYRIMIDINE DERIVATIVES, AND THEIR USE FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS
    3.
    发明专利
    3-SUBSTITUTED PYRIDO [3',4':4,5]THIENO[2,3-D]PYRIMIDINE DERIVATIVES, AND THEIR USE FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS 未知

    公开(公告)号：HU0002736A2

    公开(公告)日：2001-02-28

    申请号：HU0002736

    申请日：1998-05-29

    Applicant: BASF AG

    Inventor： DR BACH ALFRED ,  DULLWEBER UTA ,  DR EMLING FRANZ ,  GARCIA-LADONA FRANCISCO-JAVIER ,  STARCK DOROTHEA ,  DR STEINER GERD ,  DR TESCHENDORF HANS-JUERGEN ,  DR WICKE KARSTEN

    IPC: A61K31/505 ,  A61K31/519 ,  A61P25/00 ,  A61P25/24 ,  A61P43/00 ,  C07D495/14

    Abstract: PCT No. PCT/EP98/03231 Sec. 371 Date Dec. 8, 1999 Sec. 102(e) Date Dec. 8, 1999 PCT Filed May 29, 1998 PCT Pub. No. WO98/56793 PCT Pub. Date Dec. 17, 19983-Substituted 3,4,5,6,7,8-hexahydropyrido [3',4':4,5]-thieno[2,3-d]pyrimidine derivatives of the formula I where R1 is a hydrogen atom, a C1-C4-alkyl group, an acetyl group, a phenylalkyl C1-C4 radical, the aromatic system being unsubstituted or substituted by halogen, C1-C4-alkyl, trifluoromethyl, hydroxyl, C1-C4-alkoxy, amino, cyano or nitro groups, or is a phenylalkanone radical, it being possible for the phenyl group to be substituted by halogen, R2 is a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which is unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, trifluoromethyl, trifluoromethoxy, hydroxyl, C1-C4-alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and which may be fused to a benzene nucleus which can be unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, hydroxyl, trifluoromethyl, C1-C4-alkoxy, amino, cyano or nitro groups and may contain 1 nitrogen atom, or to a 5- or 6-membered ring which may contain 1-2 oxygen atoms, A is NH or an oxygen atom, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z is a nitrogen atom, carbon atom or CH, it also being possible for the linkage between Y and Z to be a double bond, and n is 2, 3 or 4, and the physiologically tolerated salts thereof.

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