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1.发明专利
公开(公告)号：HU220621B1
公开(公告)日：2002-03-28
申请号：HU9701975
申请日：1995-10-07
Applicant: BASF AG
Inventor： DR AMBERG WILHELM , DR BAUMANN ERNST , DR KLING ANDREAS , DR KLINGE DAGMAR , DR MUELLER STEFAN , DR RASCHACK MANFRED , DR RHEINHEIMER JOACHIM , DR RIECHERS HARTMUT , DR UNGER LILIANE , DR VOGELBACHER UWE JOSEF , DR WERNET WOLFGANG
IPC: C07D251/30 , A61K31/505 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , C07D239/00 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/12 , C07D251/52 , C07D257/02 , C07D309/00 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048
Abstract: Heterocyclyl-substd. propanoic acids and their derivs., of formula (I), are new. R = formyl, tetrazolyl, nitrile, COOH or a gp. that can be hydrolysed to COOH; X = N or CR14; R2 = H, OH, NH2, alkylamino, dialkylamino, halo, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; R14 = H or 1-5 C alkyl; R3 = R2 or alkoxyimino; or CR3 + CR14 = 5 or 6 membered alkylene or alkenyl ring (opt. substd. by 1-2 alkyl) in which a methylene can be replaced by O, S, NH or alkylamino; R4, R5 = phenyl or naphthyl (both opt. substd. by one or more halo, NO2, CN, OH, alkyl, haloalkyl, alkoxy, haloalkyloxy, phenoxy, alkylthio, NH2, alkylamine or dialkylamino) or 3-7 C cycloalkyl; or the phenyl or naphthyl gps. are opt. bonded at the O- position (by a bond, CH2, O, S, SO2, ethylene, ethenylene or opt. alkylated amino); R6 = H, 1-8 C alkyl, 2-6 C alkenyl, 3-6 C alkynyl, 3-8 C cycloalkyl (all opt. substd. by 1 or more halo, NO2, CN, alkoxy 3-6 C alkenyloxy, 3-6 C alkynyloxy, alkylthio, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, 3-8 C alkylcarbonylalkyl, alkylamino, dialkylamino, phenyl, Ph or OPh), Ar or Het; Y = S, O or bond; Q = S, O, SO, SO2 or bond; Ph = substd. phenyl, where substits. are halo, NO2, CN, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; Ar = phenyl or naphthyl (both opt. substd. by 1 or more halo, NO2, CN, OH, NH2, alkylamino, dialkylamino or OCH2CH2O); Het = 5 or 6 membered heteroaromatic with 1-3 N atoms and/or one S or O (opt. substd. by 1-4 halo and/or 1 or 2 alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, phenyl, phenoxy or phenyl carbonyl (where the phenyl is opt. substd. by 1-5 halo and/or 1-3 alkyl, haloalkyl, alkoxy, haloalkoxy and/or alkylthio)); alkyl and alkoxy have 1-4 C unless otherwise stated; provided that R6 is not H when Q = bond.
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公开(公告)号：HU0000664A2
公开(公告)日：2001-04-28
申请号：HU0000664
申请日：1997-09-02
Applicant: BASF AG
Inventor： AMBERG WILHELM , HERGENROEDER STEFAN , JANSEN ROLF , DR KLING ANDREAS , DR KLINGE DAGMAR , RASCHACK MANFRED , DR RIECHERS HARTMUT , DR UNGER LILIANE
IPC: A61K31/505 , A61K31/506 , A61K31/519 , A61P9/04 , A61P9/08 , A61P9/12 , A61P43/00 , C07C59/66 , C07C69/734 , C07D239/34 , C07D239/52 , C07D239/60 , C07D239/70 , C07D491/04 , C07D491/048
Abstract: The invention relates to carboxylic acid derivatives of the formula Iwhere the radicals have the meanings stated in the description, and to their use as drugs.
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公开(公告)号：HU0200709A2
公开(公告)日：2002-07-29
申请号：HU0200709
申请日：2000-01-12
Applicant: BASF AG
Inventor： BLUMBACH KAI , NEUMANN-SCHULTZ BARBARA , SCHOEBEL DIETMAR , STARCK DOROTHEA , DR TREIBER HANS-JOERG , DR UNGER LILIANE
IPC: C07D249/14 , A61K31/41 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/436 , A61K31/4439 , A61K31/4725 , A61K31/473 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/55 , A61P3/04 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P43/00 , C07D249/12 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/04 , C07D491/052
Abstract: Triazole compounds of the following formulawhere R1, R2, A and B have the meanings given in the description are described. The compounds according to the invention possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to the influence of dopamine D3 ligands.
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公开(公告)号：HU0104416A2
公开(公告)日：2002-04-29
申请号：HU0104416
申请日：1999-11-12
Applicant: BASF AG
Inventor： GROSS GERHARD , DR MUNSCHAUER RAINER , DR STEINER GERD , DR TESCHENDORF HANS-JUERGEN , TRAUT MARTIN , DR UNGER LILIANE
IPC: C07D403/06 , A61K31/403 , A61K31/4045 , A61K31/407 , A61K31/4184 , A61K31/424 , A61K31/427 , A61K31/4709 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/542 , A61P25/00 , A61P25/28 , A61P25/30 , A61P25/36 , C07D209/52 , C07D407/12 , C07D409/12 , C07D417/06 , C07D471/04 , C07D498/04 , C07D513/04
Abstract: The invention relates to the use of N-substituted 3-azabicycloalkane derivatives of formula (I), wherein B, R , R and n have the meanings given in the description, for combating diseases of addiction and other diseases of the central nervous system.
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公开(公告)号：HU0003332A2
公开(公告)日：2001-06-28
申请号：HU0003332
申请日：1998-07-03
Applicant: BASF AG
Inventor： BLANK STEFAN , LE BRIS THEOPHILE-MARIE , NEUMANN-SCHULTZ BARBARA , STARCK DOROTHEA , DR TESCHENDORF HANS-JUERGEN , DR TREIBER HANS-JOERG , DR UNGER LILIANE , DR WICKE KARSTEN
IPC: A61K31/33 , A61K31/41 , A61K31/4196 , A61K31/454 , A61K31/506 , A61K31/53 , A61K31/551 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D249/08 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Triazole compounds of the following formula:where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.
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Patent Agency Ranking
公开(公告)号：HU0200520A2
公开(公告)日：2002-07-29
申请号：HU0200520
申请日：1999-12-22
Applicant: BASF AG
Inventor： DR EMLING FRANZ , GARCIA-LADONA FRANCISCO JAVIER , DR HOFMANN HANS-PETER , HOLZENKAMP UTA , LUBISCH WILFRIED , SCHELLHAAS KURT , STARCK DOROTHEA , DR STEINER GERD , DR SZABO LASZLO , DR UNGER LILIANE
IPC: C07D275/06 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/551 , A61P9/10 , A61P25/28 , C07D401/12 , C07D417/12 , C07D471/04
Abstract: The invention relates to the utilisation of compounds of formula (I) wherein the substituents have the meanings given in the description. The invention also relates to the salts thereof comprising pharmacologically compatible acids for producing medicaments for the prophylaxis and therapy of cerebral ischaemia and strokes.
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公开(公告)号：HU0103099A2
公开(公告)日：2002-03-28
申请号：HU0103099
申请日：1999-07-20
Applicant: BASF AG
Inventor： HOEGER THOMAS , JUCHELKA FRIEDER , DR STEINER GERD , TESCHENDORF HANS-JUERGEN , DR UNGER LILIANE
IPC: A61K31/4184 , A61P25/20 , A61P25/24 , A61P25/30 , C07D403/06
Abstract: The invention relates to compounds of formula (1), wherein R , R and R have the meaning cited in the description. The novel substances are suitable for use in disease control.
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公开(公告)号：HU0200522A2
公开(公告)日：2002-06-29
申请号：HU0200522
申请日：2000-01-12
Applicant: BASF AG
Inventor： BLUMBACH KAI , NEUMANN-SCHULTZ BARBARA , SCHOEBEL DIETMAR , STARCK DOROTHEA , DR TREIBER HANS-JOERG , DR UNGER LILIANE
IPC: C07D249/14 , A61K31/41 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/436 , A61K31/4439 , A61K31/4725 , A61K31/473 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/55 , A61P3/04 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P43/00 , C07D249/12 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/04 , C07D491/052
Abstract: Triazole compounds of the following formulawhere R1, R2, A and B have the meanings given in the description are described. The compounds according to the invention possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to the influence of dopamine D3 ligands.
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公开(公告)号：HU0103358A2
公开(公告)日：2002-05-29
申请号：HU0103358
申请日：1999-07-20
Applicant: BASF AG
Inventor： DR HOEGER THOMAS , JUCHELKA FRIEDER , DR STEINER GERD , DR TESCHENDORF HANS-JUERGEN , DR UNGER LILIANE
IPC: A61K31/425 , A61K31/428 , A61P25/00 , C07D417/06
Abstract: Compounds of the formula I:in which R1, R2, R3 and R4 have the meanings stated in the description, are described.The novel compounds are suitable for controlling diseases.
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公开(公告)号：HU0000553A2
公开(公告)日：2001-04-28
申请号：HU0000553
申请日：1997-12-04
Applicant: BASF AG
Inventor： AMBERG WILHELM , HERGENROEDER STEFAN , JANSEN ROLF , DR KLING ANDREAS , DR KLINGE DAGMAR , DR RASCHACK MANFRED , DR RIECHERS HARTMUT , DR UNGER LILIANE
IPC: C07D253/06 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/53 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , C07D237/14 , C07D237/16 , C07D241/18 , C07D253/07 , C07D253/075 , C07D253/10 , C07D403/12 , C07D491/04
Abstract: The present invention relates to carboxylic acid derivatives of the formula Iwhere the substituents have the meanings explained in the description, and to preparation and use as endothelin receptor antagonists.
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