公开(公告)号：ID24669A

公开(公告)日：2000-07-27

申请号：ID20000322

申请日：1998-07-07

Applicant: BASF AG

Inventor： BERND JANSSEN ,  TERESA BARLOZZARI ,  ANDREAS HAUPT ,  THOMAS ZIERKE ,  ANDREAS KLING

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K7/06 ,  C12P19/34

Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L  (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

公开(公告)号：RU2153504C2

公开(公告)日：2000-07-27

申请号：RU96123123

申请日：1995-04-26

Applicant: BASF AG

Inventor： VIL GEL M AMBERG ,  KHARAL D BERNARD ,  EHRNST BUSHMANN ,  ANDREAS KHAUPT ,  LOTAR JANICHKE ,  BERND JANSSEN ,  UL RIKH KARL ,  ANDREAS KLING ,  SHTEFAN MJULLER ,  BERND DEH POTTSOLLI ,  KURT RITTER ,  MARKO TIES ,  TOMAS TSIRKE

IPC: A61K38/08 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  A61K38/00 ,  C07K7/06 ,  C07K14/52

Abstract: medicine. SUBSTANCE: described is pentapeptide hydrochloride of formula I: Me2Val-Val-MeVai-Pro-Pro-NHBzl.HCl (I) wherein Me is methyl and Bzl is benzyl. Compound has antitumor activity. Also described are methods of preparation thereof. EFFECT: improved properties of the title compound. 6 cl, 2 ex

公开(公告)号：HK1049001A1

公开(公告)日：2003-04-25

申请号：HK03101187

申请日：2003-02-18

Applicant: BASF AG

Inventor： ANDREAS KLING ,  HERVE GENESTE ,  UDO LANGE ,  ARNULF LAUTERBACH ,  CLAUDIA ISABELLA GRAEF ,  THOMAS SUBKOWSKI ,  UTA HOLZENKAMP ,  HELMUT MACK ,  JENS SADOWSKI ,  WILFRIED HORNBERGER ,  VOLKER LAUX

IPC: C07D20060101 ,  A61K20060101 ,  A61K31/4402 ,  A61K31/55 ,  A61K31/5513 ,  A61P20060101 ,  A61P3/14 ,  A61P5/18 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P13/12 ,  A61P17/02 ,  A61P17/06 ,  A61P19/00 ,  A61P19/08 ,  A61P19/10 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D213/74 ,  C07D223/20 ,  C07D243/38 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D495/14

公开(公告)号：RU2180335C2

公开(公告)日：2002-03-10

申请号：RU97107617

申请日：1995-10-07

Applicant: BASF AG

Inventor： KHARTMUT RIKHERS ,  DAGMAR KLINGE ,  VIL KHEL M AMBERG ,  ANDREAS KLING ,  SHTEFAN MJULLER ,  EHRNST BAUMANN ,  JOAKHIM RAJNKHAJMER ,  UVE JOZEF FOGEL BAKHER ,  VOL FGANG VERNET ,  LILIANE UNGER ,  MANFRED RASHAK

IPC: C07D251/30 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  C07D239/00 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D239/38 ,  C07D239/60 ,  C07D239/70 ,  C07D239/96 ,  C07D251/12 ,  C07D251/52 ,  C07D257/02 ,  C07D309/00 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048

Abstract: organic synthesis. SUBSTANCE: invention provides novel carboxylic acid derivatives having general formula I: (I) and containing heterocyclic moieties. Compound possess biological activity, in particular they inhibit binding of endothelin to receptors and can be used for treatment of hypertension, myocardial infarction, renal insufficiency, and other maladies. In the formula I, (i) R1 denotes tetrazole, nitrile, carboxylic group, group COOR7, in which R7 is C1-C4-alkyl or alkali of alkaliearth cation, group -CONHSO2R8, in which R8 is C1-C4-alkyl, or group -CONHSO2R9, in which R9 is C1-C4-alkyl; (ii) R2 denotes hydroxy group, amino group, di-C1-C4- alkylaino group, or C1-C4-alkoxy group; (iii) X denotes nitrogen or radical CR10, in which R10 is hydrogen or C1-C5- alkyl, or CR10 and CR3 together form 5- or 6-membered alkylene or alkenylene ring optionally substituted by 1 or 2 C1- C4-alkyl group and in which one methylene group can be substituted by oxygen, imino or C1-C4-imino group; (iv) R3 denotes mono- or di-C1-C4-alkyl group, C1- C4-alkyl, C1-C4-alkoxy, or CR3 together with CR10 form above-described ring; (v) R4 and R5 each denote phenyl optionally substituted by halogen, C1-C4-alkyl or C1-C4-alkoxy, provided that two phenyls are in ortho-position to each other and linked by an ordinary linkage, methylene or ethylene group, or C3- C7- cycloalkyl group; (vi) R6 denotes C1-C8-alkyl or C3-C6-alkenyl optionally substituted by halogen, cyano, C1-C4- alkoxy, C1-C4-alkylthio, or phenyl; phenyl optionally substituted by one or two groups selected from halogen, C1-C4- alkyl, C1-C4-alkoxyl; cycloalkyl optionally substituted by C1-C4-alkyl; or five- or six-membered heterocyclic residue containing one sulfur or oxygen atom and optionally substituted by C1-C4-alkyl; and (vii) Z denotes sulfur, oxygen, sulfinyl or sulfonyl. EFFECT: extended choice of drugs. 3 tbl, 25 ex

公开(公告)号：RU2175315C2

公开(公告)日：2001-10-27

申请号：RU98106478

申请日：1996-08-29

Applicant: BASF AG

Inventor： VIL GEL M AMBERG ,  ANDREAS KLING ,  DAGMAR KLINGE ,  KHARTMUT RIKHERS ,  LILIAN UNGER ,  MANFRED RASHAKK ,  SHTEFAN KHERGENREDER ,  BERND EHL GER ,  SABINA SHUL T

IPC: A61K31/00 ,  A61K31/19 ,  C07D317/02 ,  A61K31/192 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/35 ,  A61K31/352 ,  A61K31/357 ,  A61K31/36 ,  A61K31/435 ,  A61K31/44 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  C07C53/134 ,  C07C57/30 ,  C07C57/32 ,  C07C57/38 ,  C07C59/64 ,  C07C69/616 ,  C07C69/734 ,  C07C255/00 ,  C07D213/55 ,  C07D213/64 ,  C07D221/04 ,  C07D239/26 ,  C07D239/34 ,  C07D239/52 ,  C07D239/70 ,  C07D257/04 ,  C07D307/79 ,  C07D317/50 ,  C07D317/60 ,  C07D319/02 ,  C07D319/18

公开(公告)号：HK1045846A1

公开(公告)日：2002-12-13

申请号：HK02107037

申请日：2002-09-26

Applicant: BASF AG

Inventor： HEINZ HILLEN ,  MARTIN SCHMIDT ,  HELMUT MACK ,  WERNER SEITZ ,  ANDREAS HAUPT ,  JOHANN-CHRISTIAN ZECHEL ,  ANDREAS KLING

IPC: C07K20060101 ,  C12N9/99 ,  A61K20060101 ,  A61K38/00 ,  A61K38/55 ,  A61P20060101 ,  A61P1/04 ,  A61P1/18 ,  A61P5/14 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/02 ,  A61P19/02 ,  A61P21/04 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P37/02 ,  C07B43/00 ,  C07D20060101 ,  C07D401/12 ,  C07D409/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/068 ,  C07K5/072 ,  C07K5/078

公开(公告)号：HK1041007A1

公开(公告)日：2002-06-28

申请号：HK02101870

申请日：2002-03-12

Applicant: BASF AG

Inventor： KURT RITTER ,  BERND JANSSEN ,  ANDREAS HAUPT ,  ANDREAS KLING ,  TERESA BARLOZZARI ,  WILHELM AMBERG

IPC: A61K38/00 ,  C07K20060101 ,  A61K20060101 ,  A61K35/56 ,  A61P35/00 ,  C07K5/103 ,  C07K5/117 ,  C07K7/02