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    FERMENTATIVE PRODUCTION OF FINE CHEMICALS
    1.
    发明申请
    FERMENTATIVE PRODUCTION OF FINE CHEMICALS 审中-公开
    发酵生产精细化工

    公开(公告)号：WO2005116228A8

    公开(公告)日：2007-03-15

    申请号：PCT/EP2005005728

    申请日：2005-05-27

    Applicant: BASF AG ,  POMPEJUS MARKUS ,  FREYER STEPHAN ,  LOHSCHEIDT MARKUS ,  ZELDER OSKAR ,  BOY MATTHIAS

    Inventor： POMPEJUS MARKUS ,  FREYER STEPHAN ,  LOHSCHEIDT MARKUS ,  ZELDER OSKAR ,  BOY MATTHIAS

    IPC: C12P7/46 ,  C12N15/54 ,  C12P1/00 ,  C12P13/00 ,  C12P13/02 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/24 ,  C12P19/02 ,  C12P19/14 ,  C12P19/20 ,  C12P25/00

    CPC classification number: C12P25/00 ,  C12P7/46 ,  C12P13/02 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/24 ,  C12P19/02 ,  C12P19/14 ,  C12P19/20 ,  Y02P20/582

    Abstract: The invention relates to a method for the production of at least one microbial metabolic product having at least 3 C atoms or at least 2 C atoms and at least one N atom by means of sugar-based microbial fermentation. The inventive method involves the following steps: a) producing a sugar-containing liquid medium having a monosaccharide content of more than 20 weight percent from a starch source, wherein the sugar-containing liquid medium also comprises nonstarch-containing solid components of the starch source; b) fermenting the sugar-containing liquid medium for the production of the metabolic product(s) and c) separating or isolating at least one metabolic product from the fermentation broth, wherein the microorganism strain producing the desired metabolic product(s) is cultivated with the sugar-containing liquid medium, which is obtained by: a1) milling the starch source and a2) liquefying the ground material in an aqueous fluid in the presence of at least one starch liquefying enzyme and subsequently saccharifyng the resulting liquid using at least one saccharifying enzyme, wherein at least part of the ground material is liquefied into an aqueous liquid by continuous or discontinuous addition.

    Abstract translation: 本发明涉及一种用于具有至少3个碳原子的至少一种微生物代谢产物的制备或由至少2个碳原子和至少1个N原子通过基于糖的微生物发酵，包括：a）含含糖液体培养基的制备具有大于一个单糖含量 20重量淀粉来源的％，含糖液体介质还包括淀粉原料的非淀粉固体组分; b）该含糖液体培养基的，用于生产（的）代谢物（或多个）发酵; 和c）耗尽或从发酵液中的至少一种代谢物，其中一方面（S）所需的（S）代谢物（S）是制造与由获得的含糖液体培养基菌株培养的微生物的隔离：a1）中研磨所述淀粉原料; 和a2）液化在水性液体的地面材料中的至少一种淀粉液化酶和随后的糖化的使用至少一种糖化酶，其中液化至少一个由连续或不连续除了水性液体中的研磨材料的子集的存在。

    FERMENTATIVE PRODUCTION OF FINE CHEMICALS
    2.
    发明申请
    FERMENTATIVE PRODUCTION OF FINE CHEMICALS 审中-公开
    发酵生产精细化工

    公开(公告)号：WO2005116228A3

    公开(公告)日：2006-05-11

    申请号：PCT/EP2005005728

    申请日：2005-05-27

    Applicant: BASF AG ,  POMPEJUS MARKUS ,  FREYER STEPHAN ,  LOHSCHEIDT MARKUS ,  ZELDER OSKAR ,  BOY MATTHIAS

    Inventor： POMPEJUS MARKUS ,  FREYER STEPHAN ,  LOHSCHEIDT MARKUS ,  ZELDER OSKAR ,  BOY MATTHIAS

    IPC: C12P7/46 ,  C12N15/54 ,  C12P1/00 ,  C12P13/00 ,  C12P13/02 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/24 ,  C12P19/02 ,  C12P19/14 ,  C12P19/20 ,  C12P25/00

    CPC classification number: C12P25/00 ,  C12P7/46 ,  C12P13/02 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/24 ,  C12P19/02 ,  C12P19/14 ,  C12P19/20 ,  Y02P20/582

    Abstract: The invention relates to a method for the production of at least one microbial metabolic product having at least 3 C atoms or at least 2 C atoms and at least one N atom by means of sugar-based microbial fermentation. The inventive method involves the following steps: a) producing a sugar-containing liquid medium having a monosaccharide content of more than 20 weight percent from a starch source, wherein the sugar-containing liquid medium also comprises nonstarch-containing solid components of the starch source; b) fermenting the sugar-containing liquid medium for the production of the metabolic product(s) and c) separating or isolating at least one metabolic product from the fermentation broth, wherein the microorganism strain producing the desired metabolic product(s) is cultivated with the sugar-containing liquid medium, which is obtained by: a1) milling the starch source and a2) liquefying the ground material in an aqueous fluid in the presence of at least one starch liquefying enzyme and subsequently saccharifyng the resulting liquid using at least one saccharifying enzyme, wherein at least part of the ground material is liquefied into an aqueous liquid by continuous or discontinuous addition.

    Abstract translation: 本发明涉及一种用于具有至少3个碳原子的至少一种微生物代谢产物的制备或由至少2个碳原子和至少1个N原子通过基于糖的微生物发酵，包括：a）含含糖液体培养基的制备具有大于一个单糖含量 20重量淀粉来源的％，含糖液体介质还包括淀粉原料的非淀粉固体组分; b）该含糖液体培养基的，用于生产（的）代谢物（或多个）发酵; 和c）耗尽或从发酵液中的至少一种代谢物，其中一方面（S）所需的（S）代谢物（S）是制造与由获得的含糖液体培养基菌株培养的微生物的隔离：a1）中研磨所述淀粉原料; 和a2）液化在水性液体的地面材料中的至少一种淀粉液化酶和随后的糖化的使用至少一种糖化酶，其中液化至少一个由连续或不连续除了水性液体中的研磨材料的子集的存在。

    FERMENTATIVE PRODUCTION OF NON-VOLATILE MICROBIAL METABOLISMPRODUCTS IN SOLID FORM
    5.
    发明专利
    FERMENTATIVE PRODUCTION OF NON-VOLATILE MICROBIAL METABOLISMPRODUCTS IN SOLID FORM 未知

    公开(公告)号：CA2623588A1

    公开(公告)日：2007-03-15

    申请号：CA2623588

    申请日：2006-09-06

    Applicant: BASF AG

    Inventor： LOHSCHEIDT MARKUS ,  FREYER STEPHAN ,  POMPEJUS MARKUS ,  SCHOLTEN EDZARD ,  ZELDER OSKAR ,  BOY MATTHIAS

    IPC: C12P19/14 ,  A23L7/104 ,  A23L35/00 ,  C12P13/08 ,  C12P13/14

    Abstract: The present invention relates to a method for the production of at least one nonvolatile microbial metabolite in solid form by sugar-based microbial fermentation, in which process a microorganism strain which produces the desired metabolites is grown using a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight based on the total weight of the liquid medium, and the volatile constituents of the fermentation liquor are subsequently largely removed, the sugar-containing liquid medium being prepared by: a1) milling selected starch feedstock from cereal grains; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where, for liquefaction purposes, at least a portion of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid. Furthermore, the invention relates to a solid formulation, of a nonvolatile microbial metabolite, obtainable by the method according to the invention; and to the use of such a solid formulation as additive or supplement for human or animal nutrition or for the treatment of textiles, leather, cellulose, paper or surfaces.

    Fermentative production of fine chemicals
    6.
    发明专利
    Fermentative production of fine chemicals 未知

    公开(公告)号：AU2005248061B2

    公开(公告)日：2010-02-11

    申请号：AU2005248061

    申请日：2005-05-27

    Applicant: BASF AG

    Inventor： POMPEJUS MARKUS ,  ZELDER OSKAR ,  LOHSCHEIDT MARKUS ,  BOY MATTHIAS ,  FREYER STEPHAN

    IPC: C12N15/54 ,  C12P1/00 ,  C12P7/46 ,  C12P13/00 ,  C12P13/02 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/24 ,  C12P19/02 ,  C12P19/14 ,  C12P19/20 ,  C12P25/00

    Abstract: The invention relates to a process for the production of at least one microbial metabolite having at least 3 carbon atoms or at least 2 carbon atoms and at least 1 nitrogen atom by means of sugar-based microbial fermentation, comprising: a) the preparation of a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight from a starch feedstock, the sugar-containing liquid medium also comprising non-starchy solid constituents of the starch feedstock; b) the fermentation of the sugar-containing liquid medium for the production of the metabolite(s); and c) depletion or isolation of at least one metabolite from the fermentation liquor, wherein a microorganism strain which produces the desired metabolite(s) is cultivated with the sugar-containing liquid medium, said liquid medium being obtained by: a1) milling the starch feedstock; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where at least some of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid.

    FERMENTATIVE PRODUCTION OF ORGANIC COMPOUNDS USING SUBSTANCES CONTAINING DEXTRIN
    8.
    发明专利
    FERMENTATIVE PRODUCTION OF ORGANIC COMPOUNDS USING SUBSTANCES CONTAINING DEXTRIN 未知

    公开(公告)号：CA2628748A1

    公开(公告)日：2007-05-31

    申请号：CA2628748

    申请日：2006-11-27

    Applicant: BASF AG

    Inventor： BOY MATTHIAS ,  FREYER STEPHAN

    IPC: C12P19/14 ,  C12P13/08 ,  C12P13/14

    Abstract: The invention relates to a method for producing at least one organic compound comprising at least 3 C-atoms or at least 2 C-atoms and at least 1 N-atom by fermentation. Said method comprises the following steps: a1) a starch source is ground in order to obtain a grinding material which contains at least one part of the non-starch containing solid components of the starch source; a2) the grinding material is suspended in an aqueous liquid and said grinding material contained in the aqueous liquid is liquefied in the presence of at least one enzyme which liquefies starch, an aqueous substance which contains dextrin (1), which contains at least one part of the non-starch containing solid components of the starch source, is obtained; and b) the aqueous substance which contains dextrin (1) is used in fermentation for cultivating a micro-organism which is capable of over-producing the organic compounds; enzymes, which hydrolyse the dextrin into monosaccharides, are not added or are added in an amount of less than 0.001 wt. %, in relation to the total weight of the used starch source.

    PRODUCCION FERMENTATIVA DE COMPUESTOS QUIMICOS FINOS.
    9.
    发明专利
    PRODUCCION FERMENTATIVA DE COMPUESTOS QUIMICOS FINOS. 未知

    公开(公告)号：MXPA06013512A

    公开(公告)日：2007-03-01

    申请号：MXPA06013512

    申请日：2005-05-27

    Applicant: BASF AG

    Inventor： LOHSCHEIDT MARKUS ,  ZELDER OSKAR ,  POMPEJUS MARKUS ,  BOY MATTHIAS ,  FREYER STEPHAN

    IPC: C12P13/00 ,  C12N15/54 ,  C12P1/00 ,  C12P7/46 ,  C12P13/02 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/24 ,  C12P19/02 ,  C12P19/14 ,  C12P19/20 ,  C12P25/00

    Abstract: La invencion se refiere a un proceso para la produccion de al menos un metabolito microbiano con al menos 3 atomos de carbono, o al menos 2 atomos de carbono y al menos 1 atomo de nitrogeno mediante fermentacion microbiana basada en azucar, que comprende: a) la preparacion de un medio liquido que contiene azucar con un contenido de monosacarido de mas del 20% en peso proveniente de un alimento de almidon, en donde el medio liquido que contiene azucar tambien comprende constituyentes solidos distintos de almidon del alimento de almidon; b) la fermentacion del medio liquido que contiene azucar para la produccion del (os) metabolito(s); y c) la deplecion o el aislamiento de al menos un metabolito a partir del licor de fermentacion, en donde una cepa de microorganismo que produce el(os) metabolito(s) de interes se cultiva en el medio liquido que contiene azucar, en donde el medio liquido se obtiene por: a1)molienda del aliento de almidon; y a2) licuefaccion de la base de molienda en un liquido acuoso en presencia de al menos una enzima que licua el almidon, seguido de sacarificacion con al menos una enzima sacarificante, en donde al menos parte de la base de molienda se licua por adicion continua o en tandas al liquido acuoso.

    10.
    发明专利
    未知

    公开(公告)号：DE102004026152A1

    公开(公告)日：2005-12-15

    申请号：DE102004026152

    申请日：2004-05-28

    Applicant: BASF AG

    Inventor： POMPEJUS MARKUS ,  FREYER STEPHAN ,  LOHSCHEIDT MARKUS ,  ZELDER OSKAR ,  BOY MATTHIAS

    IPC: C12N15/54 ,  C12P1/00 ,  C12P7/46 ,  C12P13/00 ,  C12P13/02 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/24 ,  C12P19/02 ,  C12P19/14 ,  C12P19/20 ,  C12P25/00

    Abstract: The invention relates to a process for the production of at least one microbial metabolite having at least 3 carbon atoms or at least 2 carbon atoms and at least 1 nitrogen atom by means of sugar-based microbial fermentation, comprising: a) the preparation of a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight from a starch feedstock, the sugar-containing liquid medium also comprising non-starchy solid constituents of the starch feedstock; b) the fermentation of the sugar-containing liquid medium for the production of the metabolite(s); and c) depletion or isolation of at least one metabolite from the fermentation liquor, wherein a microorganism strain which produces the desired metabolite(s) is cultivated with the sugar-containing liquid medium, said liquid medium being obtained by: a1) milling the starch feedstock; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where at least some of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid.

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