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    FERMENTATIVE PRODUCTION OF FINE CHEMICALS
    2.
    发明申请
    FERMENTATIVE PRODUCTION OF FINE CHEMICALS 审中-公开
    发酵生产精细化工

    公开(公告)号：WO2005116228A8

    公开(公告)日：2007-03-15

    申请号：PCT/EP2005005728

    申请日：2005-05-27

    Applicant: BASF AG ,  POMPEJUS MARKUS ,  FREYER STEPHAN ,  LOHSCHEIDT MARKUS ,  ZELDER OSKAR ,  BOY MATTHIAS

    Inventor： POMPEJUS MARKUS ,  FREYER STEPHAN ,  LOHSCHEIDT MARKUS ,  ZELDER OSKAR ,  BOY MATTHIAS

    IPC: C12P7/46 ,  C12N15/54 ,  C12P1/00 ,  C12P13/00 ,  C12P13/02 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/24 ,  C12P19/02 ,  C12P19/14 ,  C12P19/20 ,  C12P25/00

    CPC classification number: C12P25/00 ,  C12P7/46 ,  C12P13/02 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/24 ,  C12P19/02 ,  C12P19/14 ,  C12P19/20 ,  Y02P20/582

    Abstract: The invention relates to a method for the production of at least one microbial metabolic product having at least 3 C atoms or at least 2 C atoms and at least one N atom by means of sugar-based microbial fermentation. The inventive method involves the following steps: a) producing a sugar-containing liquid medium having a monosaccharide content of more than 20 weight percent from a starch source, wherein the sugar-containing liquid medium also comprises nonstarch-containing solid components of the starch source; b) fermenting the sugar-containing liquid medium for the production of the metabolic product(s) and c) separating or isolating at least one metabolic product from the fermentation broth, wherein the microorganism strain producing the desired metabolic product(s) is cultivated with the sugar-containing liquid medium, which is obtained by: a1) milling the starch source and a2) liquefying the ground material in an aqueous fluid in the presence of at least one starch liquefying enzyme and subsequently saccharifyng the resulting liquid using at least one saccharifying enzyme, wherein at least part of the ground material is liquefied into an aqueous liquid by continuous or discontinuous addition.

    Abstract translation: 本发明涉及一种用于具有至少3个碳原子的至少一种微生物代谢产物的制备或由至少2个碳原子和至少1个N原子通过基于糖的微生物发酵，包括：a）含含糖液体培养基的制备具有大于一个单糖含量 20重量淀粉来源的％，含糖液体介质还包括淀粉原料的非淀粉固体组分; b）该含糖液体培养基的，用于生产（的）代谢物（或多个）发酵; 和c）耗尽或从发酵液中的至少一种代谢物，其中一方面（S）所需的（S）代谢物（S）是制造与由获得的含糖液体培养基菌株培养的微生物的隔离：a1）中研磨所述淀粉原料; 和a2）液化在水性液体的地面材料中的至少一种淀粉液化酶和随后的糖化的使用至少一种糖化酶，其中液化至少一个由连续或不连续除了水性液体中的研磨材料的子集的存在。

    FERMENTATIVE PRODUCTION OF FINE CHEMICALS
    3.
    发明申请
    FERMENTATIVE PRODUCTION OF FINE CHEMICALS 审中-公开
    发酵生产精细化工

    公开(公告)号：WO2005116228A3

    公开(公告)日：2006-05-11

    申请号：PCT/EP2005005728

    申请日：2005-05-27

    Applicant: BASF AG ,  POMPEJUS MARKUS ,  FREYER STEPHAN ,  LOHSCHEIDT MARKUS ,  ZELDER OSKAR ,  BOY MATTHIAS

    Inventor： POMPEJUS MARKUS ,  FREYER STEPHAN ,  LOHSCHEIDT MARKUS ,  ZELDER OSKAR ,  BOY MATTHIAS

    IPC: C12P7/46 ,  C12N15/54 ,  C12P1/00 ,  C12P13/00 ,  C12P13/02 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/24 ,  C12P19/02 ,  C12P19/14 ,  C12P19/20 ,  C12P25/00

    CPC classification number: C12P25/00 ,  C12P7/46 ,  C12P13/02 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/24 ,  C12P19/02 ,  C12P19/14 ,  C12P19/20 ,  Y02P20/582

    Abstract: The invention relates to a method for the production of at least one microbial metabolic product having at least 3 C atoms or at least 2 C atoms and at least one N atom by means of sugar-based microbial fermentation. The inventive method involves the following steps: a) producing a sugar-containing liquid medium having a monosaccharide content of more than 20 weight percent from a starch source, wherein the sugar-containing liquid medium also comprises nonstarch-containing solid components of the starch source; b) fermenting the sugar-containing liquid medium for the production of the metabolic product(s) and c) separating or isolating at least one metabolic product from the fermentation broth, wherein the microorganism strain producing the desired metabolic product(s) is cultivated with the sugar-containing liquid medium, which is obtained by: a1) milling the starch source and a2) liquefying the ground material in an aqueous fluid in the presence of at least one starch liquefying enzyme and subsequently saccharifyng the resulting liquid using at least one saccharifying enzyme, wherein at least part of the ground material is liquefied into an aqueous liquid by continuous or discontinuous addition.

    Abstract translation: 本发明涉及一种用于具有至少3个碳原子的至少一种微生物代谢产物的制备或由至少2个碳原子和至少1个N原子通过基于糖的微生物发酵，包括：a）含含糖液体培养基的制备具有大于一个单糖含量 20重量淀粉来源的％，含糖液体介质还包括淀粉原料的非淀粉固体组分; b）该含糖液体培养基的，用于生产（的）代谢物（或多个）发酵; 和c）耗尽或从发酵液中的至少一种代谢物，其中一方面（S）所需的（S）代谢物（S）是制造与由获得的含糖液体培养基菌株培养的微生物的隔离：a1）中研磨所述淀粉原料; 和a2）液化在水性液体的地面材料中的至少一种淀粉液化酶和随后的糖化的使用至少一种糖化酶，其中液化至少一个由连续或不连续除了水性液体中的研磨材料的子集的存在。

    8.
    发明专利
    未知

    公开(公告)号：ZA200610738B

    公开(公告)日：2008-04-30

    申请号：ZA200610738

    申请日：2006-12-20

    Applicant: BASF AG

    Inventor： LOHSCHEIDT MARKUS ,  ZELDER OSKAR ,  BOY MATTHIAS ,  POMPEJUS MARKUS ,  FREYER STEPHAN

    IPC: C12N15/54 ,  C12P1/00 ,  C12P7/46 ,  C12P13/00 ,  C12P13/02 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/24 ,  C12P19/02 ,  C12P19/14 ,  C12P19/20 ,  C12P25/00

    Abstract: The invention relates to a process for the production of at least one microbial metabolite having at least 3 carbon atoms or at least 2 carbon atoms and at least 1 nitrogen atom by means of sugar-based microbial fermentation, comprising: a) the preparation of a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight from a starch feedstock, the sugar-containing liquid medium also comprising non-starchy solid constituents of the starch feedstock; b) the fermentation of the sugar-containing liquid medium for the production of the metabolite(s); and c) depletion or isolation of at least one metabolite from the fermentation liquor, wherein a microorganism strain which produces the desired metabolite(s) is cultivated with the sugar-containing liquid medium, said liquid medium being obtained by: a1) milling the starch feedstock; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where at least some of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid.

    PROCEDIMIENTO PARA LA PRODUCCION DE ACIDO D-PANTOTENICO Y/O SUS SALES COMO ADITIVO DE ALIMENTOS PARA ANIMALES.
    9.
    发明专利
    PROCEDIMIENTO PARA LA PRODUCCION DE ACIDO D-PANTOTENICO Y/O SUS SALES COMO ADITIVO DE ALIMENTOS PARA ANIMALES. 未知

    公开(公告)号：ES2274967T3

    公开(公告)日：2007-06-01

    申请号：ES02719874

    申请日：2002-02-20

    Applicant: BASF AG

    Inventor： BALDENIUS KAI-UWE ,  BECK CHRISTINE ,  FISCHER ANDREAS ,  HARZ HANS-PETER ,  LOHSCHEIDT MARKUS ,  LEEMANN MARTIN

    IPC: C12P13/00 ,  C12P13/02 ,  A23K10/12 ,  A23K20/174 ,  C12R1/10

    Abstract: Procedimiento para la producción de ácido D-pantoténico y/o sus sales, caracterizado porque e) se utiliza al menos un microorganismo que produce ácido D-pantoténico, cuya biosíntesis de ácido pantoténico (pan) y/o de isoleucina/valina (ilv) está desregulada y que forma al menos 2 g/l de sales del ácido pantoténico mediante la fermentación en un medio de cultivo, añadiéndose al medio de cultivo 0 - 20 g/l de Beta-alanina libre y/o sal de Beta-alanina, f) se conduce la solución de fermentación que contiene D-pantotenato mediante la aplicación de un campo eléctrico a través de una o varias membranas selectivas de iones, eliminándose los iones de bajo peso molecular de la solución que contiene D-pantotenato, g) se ajusta el ácido D-pantoténico libre contenido en la solución mediante la adición de una base de calcio y/o de magnesio hasta un valor de pH de 3-10, obteniéndose una solución, que contiene pantotenato de calcio y/o de magnesio y h) se somete la solución que contiene pantotenato de calcio y/o de magnesio a un secado y/o formulación.

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