公开(公告)号：JPS6442423A

公开(公告)日：1989-02-14

申请号：JP18567888

申请日：1988-07-27

Applicant: BASF AG

Inventor： ARUBUREHITO FURANKE ,  RAINAA SHIYURETSUKAA ,  YOOZEFU GURIISU ,  GERUDAFUON FUIRIPUSUBORUN ,  RIRIAANE UNGAA

IPC: A61K31/135 ,  A61P9/06 ,  A61P25/02

Abstract: PURPOSE: To prepare an oral or a parenteral therapeutic agent, comprising a specific amount of an antipode of propafenone as an active ingredient, having antiarrhythmic actions and useful for treating cardiopathy. CONSTITUTION: This antiarrhythmic therapeutic agent comprises (S)-propafenone or (R)propafenone represented by the formula as an active ingredient. The active ingredient has the structure represented by the formula and is effective in the form of a hydrochloride in treating cardiac and circulatory diseases, especially heart rate disorders. The content of the active substance in the therapeutic agent is usually 0.1-50mg, preferably 0.2-20mg, especially 1-5mg dose at a time based on 1kg body weight in a propafenone pharmaceutical preparation. The (S)-propafenone having a stronger β-blocking actions than those of (R,S)-propafenone is used for tachycardiac arrhythmia accompanied with a high catecholamine level and further for patients without still undergoing treatment with a β-blocker.