公开(公告)号：JPS6470480A

公开(公告)日：1989-03-15

申请号：JP20490388

申请日：1988-08-19

Applicant: BASF AG

Inventor： RAINAA SHIYURETSUKAA ,  MANFUREETO RASHIYATSUKU ,  YOOZEFU GURIISU

IPC: A61K31/34 ,  A61K31/343 ,  A61K31/40 ,  A61K31/44 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  C07D307/86 ,  C07D405/06 ,  C07D405/12

公开(公告)号：JPH01104064A

公开(公告)日：1989-04-21

申请号：JP18194988

申请日：1988-07-22

Applicant: BASF AG

Inventor： RAINAA SHIYURETSUKAA ,  HANSUUYURUGEN TETSUSHIENDORUFU ,  RIRIAANE UNGAA

IPC: A61K31/34 ,  A61K31/343 ,  A61P21/00 ,  A61P25/02 ,  A61P25/18 ,  C07D307/79 ,  C07D307/86 ,  C07D405/12

公开(公告)号：JPS5892681A

公开(公告)日：1983-06-02

申请号：JP20382782

申请日：1982-11-22

Applicant: BASF AG

Inventor： RAINAA SHIYURETSUKAA ,  RUUDOUITSUHI FURIIDORITSUHI ,  DEIITAA RENKE

IPC: A61K31/505 ,  A61P37/08 ,  C07D239/95 ,  C07D487/04 ,  C07D491/04 ,  C07D491/14 ,  C07D491/147

公开(公告)号：JPH04230248A

公开(公告)日：1992-08-19

申请号：JP14726791

申请日：1991-06-19

Applicant: BASF AG

Inventor： RAINAA SHIYURETSUKAA ,  HANSU PEETAA HOFUMAN ,  RATSURO TSUABO

IPC: A61K31/135 ,  A61K31/445 ,  A61P25/00 ,  C07C211/41 ,  C07C215/64 ,  C07C217/54 ,  C07C217/74 ,  C07C317/32 ,  C07C323/31 ,  C07D211/14

Abstract: 9-Amino-2-phenylbicyclo-[3.3.1]nonanes and 9-amino-2-phenylbicyclo[3.3.1]non-2-enes of the formula I I where R1 and R2 are identical or different and each is hydrogen, halogen, alkyl, alkoxy, dialkylamino, trifluoromethyl, hydroxyl, alkylthio, alkylsulfonyl or nitro, R3 and R4 are identical or different and each is hydrogen, alkyl or 1 to 5 or alkenyl or alkynyl of 2 to 5 carbon atoms, or benzyl, it also being possible for R3 and R4 together to form a saturated chain which contains from three to seven carbon atoms and can be substituted by phenyl, and where is a single or double bond, are used for producing drugs which act, in particular, on the central nervous system.

公开(公告)号：JPS59116282A

公开(公告)日：1984-07-05

申请号：JP21879483

申请日：1983-11-22

Applicant: Basf Ag

Inventor： RAINAA SHIYURETSUKAA ,  PEETAA SHIYUMITSUTO ,  PEETAA TSUEE TEIIME ,  DEIITAA RENKE ,  HANSUUYURUGEN TESHIENDORUFU ,  MARUTEIN TORAUTO ,  KURAUSU DEE MIYURAA ,  HANSU PEETAA HOFUMAN ,  HORUSUTO KURAISUKOTSUTO

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/365 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P37/08 ,  A61P43/00 ,  C07D311/08 ,  C07D311/16 ,  C07D311/80

CPC classification number: C07D311/80 ,  C07D311/16

公开(公告)号：JPS6471881A

公开(公告)日：1989-03-16

申请号：JP22257888

申请日：1988-09-07

Applicant: BASF AG

Inventor： ARUBUREHITO FURANKE ,  BERUNTO OSUTERUZEERUTO ,  RAINAA SHIYURETSUKAA ,  BEATORIISU BENDENBATSUHA ,  GERUDA FUON FUIRIBUSUBORUN

IPC: A61K31/505 ,  A61K31/55 ,  A61P9/06 ,  C07D471/14 ,  C07D487/14

公开(公告)号：JPS6442423A

公开(公告)日：1989-02-14

申请号：JP18567888

申请日：1988-07-27

Applicant: BASF AG

Inventor： ARUBUREHITO FURANKE ,  RAINAA SHIYURETSUKAA ,  YOOZEFU GURIISU ,  GERUDAFUON FUIRIPUSUBORUN ,  RIRIAANE UNGAA

IPC: A61K31/135 ,  A61P9/06 ,  A61P25/02

Abstract: PURPOSE: To prepare an oral or a parenteral therapeutic agent, comprising a specific amount of an antipode of propafenone as an active ingredient, having antiarrhythmic actions and useful for treating cardiopathy. CONSTITUTION: This antiarrhythmic therapeutic agent comprises (S)-propafenone or (R)propafenone represented by the formula as an active ingredient. The active ingredient has the structure represented by the formula and is effective in the form of a hydrochloride in treating cardiac and circulatory diseases, especially heart rate disorders. The content of the active substance in the therapeutic agent is usually 0.1-50mg, preferably 0.2-20mg, especially 1-5mg dose at a time based on 1kg body weight in a propafenone pharmaceutical preparation. The (S)-propafenone having a stronger β-blocking actions than those of (R,S)-propafenone is used for tachycardiac arrhythmia accompanied with a high catecholamine level and further for patients without still undergoing treatment with a β-blocker.

公开(公告)号：JPS5855474A

公开(公告)日：1983-04-01

申请号：JP15285682

申请日：1982-09-03

Applicant: BASF AG

Inventor： RAINAA SHIYURETSUKAA ,  RUUDOUITSUHI FURIIDORITSUHI ,  DEIITAA RENKE

IPC: A61K31/425 ,  A61K31/428 ,  A61P37/08 ,  C07D277/60 ,  C07D277/82 ,  C07D277/84

Abstract: Thiazolyloxamic acids and their derivatives of the general formula I processes for their preparation, and pharmaceutical formulations which contain these compounds and are useful as drugs for treating allergic disorders.

公开(公告)号：JPS56133275A

公开(公告)日：1981-10-19

申请号：JP2323781

申请日：1981-02-20

Applicant: BASF AG

Inventor： RAINAA SHIYURETSUKAA ,  FURITSUTSUUFURIIDAA FURITSUKER ,  ARUBUREHITO FURANKE ,  DEIITAA RENKE ,  YOOZEFU GURIISU

IPC: A61K31/42 ,  A61P9/00 ,  A61P9/12 ,  A61P25/02 ,  C07D261/08 ,  C07D261/10 ,  C07D261/18 ,  C07F9/653