公开(公告)号：JPH01104064A

公开(公告)日：1989-04-21

申请号：JP18194988

申请日：1988-07-22

Applicant: BASF AG

Inventor： RAINAA SHIYURETSUKAA ,  HANSUUYURUGEN TETSUSHIENDORUFU ,  RIRIAANE UNGAA

IPC: A61K31/34 ,  A61K31/343 ,  A61P21/00 ,  A61P25/02 ,  A61P25/18 ,  C07D307/79 ,  C07D307/86 ,  C07D405/12

公开(公告)号：JPS63307879A

公开(公告)日：1988-12-15

申请号：JP12217288

申请日：1988-05-20

Applicant: BASF AG

Inventor： GERUTO SHIYUTAINAA ,  YURUGEN PUFUISUTAA ,  HANSUUYURUGEN TETSUSHIENDORUFU ,  RIRIAANE UNGAA ,  RUDORUFU BINDAA

IPC: A61K31/55 ,  A61P21/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/20 ,  C07D487/04

公开(公告)号：JPS6442423A

公开(公告)日：1989-02-14

申请号：JP18567888

申请日：1988-07-27

Applicant: BASF AG

Inventor： ARUBUREHITO FURANKE ,  RAINAA SHIYURETSUKAA ,  YOOZEFU GURIISU ,  GERUDAFUON FUIRIPUSUBORUN ,  RIRIAANE UNGAA

IPC: A61K31/135 ,  A61P9/06 ,  A61P25/02

Abstract: PURPOSE: To prepare an oral or a parenteral therapeutic agent, comprising a specific amount of an antipode of propafenone as an active ingredient, having antiarrhythmic actions and useful for treating cardiopathy. CONSTITUTION: This antiarrhythmic therapeutic agent comprises (S)-propafenone or (R)propafenone represented by the formula as an active ingredient. The active ingredient has the structure represented by the formula and is effective in the form of a hydrochloride in treating cardiac and circulatory diseases, especially heart rate disorders. The content of the active substance in the therapeutic agent is usually 0.1-50mg, preferably 0.2-20mg, especially 1-5mg dose at a time based on 1kg body weight in a propafenone pharmaceutical preparation. The (S)-propafenone having a stronger β-blocking actions than those of (R,S)-propafenone is used for tachycardiac arrhythmia accompanied with a high catecholamine level and further for patients without still undergoing treatment with a β-blocker.

公开(公告)号：JPS63156763A

公开(公告)日：1988-06-29

申请号：JP30031487

申请日：1987-11-30

Applicant: BASF AG

Inventor： UERUNAA ZAITSU ,  RIRIAANE UNGAA ,  MANFUREETO RASHIYAKU ,  FUEREENA BARUDEINGAA ,  KURAUSU RIYUUBUZAAMEN ,  YOOZEFU GURIISU

IPC: A61K31/275 ,  A61K31/335 ,  A61K31/357 ,  A61K31/36 ,  A61P1/04 ,  A61P3/00 ,  A61P9/00 ,  A61P11/00 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C253/30 ,  C07C255/32 ,  C07C255/33 ,  C07C255/35 ,  C07C255/37 ,  C07C255/42 ,  C07C255/53 ,  C07C255/58 ,  C07D317/50 ,  C07D317/60 ,  C07D319/08 ,  C07D319/18 ,  C07D321/00

公开(公告)号：JPS63307883A

公开(公告)日：1988-12-15

申请号：JP12217388

申请日：1988-05-20

Applicant: BASF AG

Inventor： GERUTO SHIYUTAINAA ,  HANSUUYURUGEN TETSUSHIENDORUFU ,  RIRIAANE UNGAA ,  RUDORUFU BINDAA

IPC: A61K31/55 ,  A61P21/02 ,  A61P25/00 ,  A61P25/20 ,  C07D495/04

公开(公告)号：JPS62190155A

公开(公告)日：1987-08-20

申请号：JP1742487

申请日：1987-01-29

Applicant: BASF AG

Inventor： RIRIAANE UNGAA ,  MANFUREEDO RASHIYAAKU ,  FUEREENA BARUDEINGAA ,  FUERUDEINANDO DENGERU ,  OSUKAA EERUMAN ,  HANSU YOERUKU TORAIBAA ,  UERUNAA ZAITSU

IPC: A61K31/275 ,  A61K31/335 ,  A61K31/357 ,  A61P7/02 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/43 ,  C07C255/53 ,  C07C255/58 ,  C07D317/58 ,  C07D319/08 ,  C07D319/18 ,  C07D321/12 ,  C07D325/00

公开(公告)号：JPS6219590A

公开(公告)日：1987-01-28

申请号：JP16100986

申请日：1986-07-10

Applicant: BASF AG

Inventor： GERUTO SHIYUTAINAA ,  HANSU YURUGEN TETSUSHIENDORUFU ,  RIRIAANE UNGAA

IPC: A61K31/55 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  C07D495/04