公开(公告)号：JPH10324681A

公开(公告)日：1998-12-08

申请号：JP1863598

申请日：1998-01-30

Applicant: BASF AG

Inventor： FRITZ GERHARD DR ,  WACHE HARRO DR ,  ECK BERND ,  HEILEK JOERG ,  GRUENENWALD THOMAS ,  GRAUENHORST KARL RAINER

IPC: A61K31/415 ,  A61K31/495 ,  A61P31/04 ,  C07D233/28 ,  C07D233/54 ,  C07D233/58 ,  C07D233/60 ,  C07D233/62 ,  C07D233/64 ,  C07D233/92 ,  C07D405/06 ,  C07D409/12 ,  C07D521/00

Abstract: PROBLEM TO BE SOLVED: To purify the subject compound in an industrial scale and simple and sure manner by carrying out crystallization on cooling surface on which crystals of an imidazole compound are grown. SOLUTION: In a method for purifying either one of an imidazole of formula I (R to R are each H, a halogen, acetyl, carboxyl, a 1-20C alkyl, a 6-12C aryl, etc.), and an effective substance containing the imidazole as a base by crystallization, the crystallization is carried out on at least one cooling surface on which crystals of imidazole compound grows. The effective substance containing the imidazole as a base includes e.g. secnidazole of formula II or climbazole of formula III. In the purification, crystals of imidazole compound which grows on the cooling surface are preferably brought through the cooling surface into contact with a liquid mixture (preferably containing at least 80 wt.% imidazole compound) of a substance containing an imidazole compound to be purified and the cooling surface is cooled to form the corresponding crystals.

公开(公告)号：DE19703651A1

公开(公告)日：1998-08-06

申请号：DE19703651

申请日：1997-01-31

Applicant: BASF AG

Inventor： FRITZ GERHARD DR ,  WACHE HARRO DR ,  ECK BERND ,  HEILEK JOERG ,  GRUENENWALD THOMAS ,  GRAUENHORST KARL RAINER

IPC: A61K31/415 ,  A61K31/495 ,  A61P31/04 ,  C07D233/28 ,  C07D233/54 ,  C07D233/58 ,  C07D233/60 ,  C07D233/62 ,  C07D233/64 ,  C07D233/92 ,  C07D405/06 ,  C07D409/12 ,  C07D521/00 ,  A01N43/50