公开(公告)号：CA2257854A1

公开(公告)日：1997-12-24

申请号：CA2257854

申请日：1997-06-05

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  SCH NHERR MICHAEL ,  FRETSCHNER ERICH ,  DIENER RALPH ,  H RTL AXEL PAUL ,  J GER KARL-FRIEDRICH ,  HOFMANN JUERGEN

IPC: C07C59/70 ,  A01N25/00 ,  A01N39/02 ,  A01N39/04 ,  C07C51/41 ,  C07C59/68

Abstract: A process for the production of alkaline metal salts and earth alkali metal salts of aryloxy-C1-C4-alkane carboxylic acids by reacting the basic aryloxyC1-C4-alkane carboxylic acids with alkaline metal bases or earth alkali metal bases in the melt, by extruding a mixture of the aryloxy-C1-C4-alkane carboxylic acid and an at least stoichiometric quantity of an alkaline metal base or an earth alkali metal base, which are partially or completely converted in the reaction conditions into volatile substances. The invention also concerns the extrudates thus obtainable and the use of the extrudates which contain an aryloxy-C1-C4-alkane carboxylic acid with herbicidal action to combat undesired plant growth.

公开(公告)号：CA2232356A1

公开(公告)日：1997-05-01

申请号：CA2232356

申请日：1996-10-23

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER ,  HOFMANN JUERGEN ,  BREITENBACH JOERG ,  H RTL AXEL PAUL

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K9/02 ,  A61K31/19 ,  A61K31/275 ,  A61K31/40 ,  A61K31/455

Abstract: The invention concerns a method of producing multi-layer medicaments in solid form for oral or rectal administration. At least two substances, which each comprise a thermoplastic, pharmacologically acceptable polymer binder which is soluble or can swell in a physiological environment, at least one of the substances comprising a pharmaceutical active substance, are coextruded and the coextruded multi-layer material is shaped to form the desired medicament.

公开(公告)号：CA2232357A1

公开(公告)日：1997-05-01

申请号：CA2232357

申请日：1996-10-22

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  H RTL AXEL PAUL ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER ,  ROSENBERG JOERG

IPC: A61K9/16 ,  A61K9/20 ,  A61J3/06 ,  A61K31/19 ,  A61K31/275 ,  A61K31/40 ,  A61K31/455 ,  A61K31/60 ,  A61K47/32 ,  A61K47/38

Abstract: The invention concerns a method of producing medicaments in solid form by mixing at least one pharmacologically acceptable polymer binder, at least one pharmaceutical active substance and optionally conventional pharmaceutical additives, extruding the mixture and shaping the medicament, a pre-mixture being prepared from the components and fed into the extruder. The method according to the invention enables high-quality medicaments to be produced in a simple and careful manner.