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1.发明申请METHODS FOR THE PREPARATION OF LYSINE BY FERMENTATION OF CORYNEBACTERIUM GLUTAMICUM 审中-公开通过发酵玉米淀粉制备赖氨酸的方法
公开(公告)号：WO2005059139A3
公开(公告)日：2005-08-11
申请号：PCT/IB2004004429
申请日：2004-12-17
Applicant: BASF AG , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KROEGER BURKHARD , KIEFER PATRICK , HEINZLE ELMAR , WITTMANN CHRISTOPH
Inventor： ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KROEGER BURKHARD , KIEFER PATRICK , HEINZLE ELMAR , WITTMANN CHRISTOPH
Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose- l,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
Abstract translation: 本发明的特征在于通过使酶编码基因（即果糖-1,6-二磷酸酶）失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。 在优选的实施方案中，本发明提供了通过增加果糖-1,6-二磷酸酶活性的表达来增加谷氨酸棒杆菌中赖氨酸的产生的方法。 本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。 在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。
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公开(公告)号：WO2007051725A3
公开(公告)日：2007-06-28
申请号：PCT/EP2006067680
申请日：2006-10-23
Applicant: BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE G , YOCUM R ROGERS , PATTERSON THOMAS A , WILLIAMS MARK , HERMAN THERON
Inventor： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE G , YOCUM R ROGERS , PATTERSON THOMAS A , WILLIAMS MARK , HERMAN THERON
CPC classification number: C12P13/12 , A23K10/16 , A23K20/142 , A23K40/10 , C12N15/52
Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.
Abstract translation: 本发明涉及用于有效制备L-氨基酸如L-甲硫氨酸的微生物和方法。 特别地，本发明涉及微生物和其中甲硫氨酸途径中高山ion素的形成和/或积累减少和/或预防的方法。
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公开(公告)号：WO2005059154A3
公开(公告)日：2005-10-13
申请号：PCT/IB2004004426
申请日：2004-12-17
Applicant: BASF AG , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KROEGER BURKHARD , KIEFER PATRICK , HEINZLE ELMAR , WITTMANN CHRISTOPH
Inventor： ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KROEGER BURKHARD , KIEFER PATRICK , HEINZLE ELMAR , WITTMANN CHRISTOPH
CPC classification number: C12N9/0006 , C12P13/08
Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., lactate dehydrogenase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of the expression of lactate dehydrogenase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
Abstract translation: 本发明的特征在于通过使酶编码基因（即乳酸脱氢酶）失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。 在优选的实施方案中，本发明提供通过乳酸脱氢酶活性的表达增加谷氨酸棒杆菌中赖氨酸的产生的方法。 本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。 在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。
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公开(公告)号：WO2007135188A2
公开(公告)日：2007-11-29
申请号：PCT/EP2007055056
申请日：2007-05-24
Applicant: BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMANN THERON
Inventor： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMANN THERON
IPC: C12P13/12
CPC classification number: C12P13/12
Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-methionine. In particular, the present invention relates to processes in which the amount of serine available for the metabolism of the microorganism is increased.
Abstract translation: 本发明涉及用于L-甲硫氨酸有效制备的微生物和方法。 特别地，本发明涉及其中可用于微生物代谢的丝氨酸量增加的方法。
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5.发明申请
公开(公告)号：WO2007020295A3
公开(公告)日：2007-05-03
申请号：PCT/EP2006065460
申请日：2006-08-18
Applicant: BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMAN THERON
Inventor： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMAN THERON
Abstract: The present invention concerns methods for the production of microorganisms with increased efficiency for methionine synthesis. The present invention also concerns microorganisms with increased efficiency for methionine synthesis. Furthermore, the present invention concerns methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.
Abstract translation: 本发明涉及生产甲硫氨酸合成效率提高的微生物的方法。 本发明还涉及甲硫氨酸合成效率提高的微生物。 此外，本发明涉及用于确定与甲硫氨酸合成有关的生物体的最佳代谢通量的方法。
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Patent Agency Ranking
公开(公告)号：WO2005121349A3
公开(公告)日：2006-04-13
申请号：PCT/IB2004004463
申请日：2004-12-17
Applicant: BASF AG , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KROEGER BURKHARD , KIEFER PATRICK , HEINZLE ELMAR , WITTMANN CHRISTOPH
Inventor： ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KROEGER BURKHARD , KIEFER PATRICK , HEINZLE ELMAR , WITTMANN CHRISTOPH
CPC classification number: C12P13/08
Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g.,
Abstract translation: 本发明的特征在于增加精细化学品例如来自微生物的赖氨酸的生产的方法，例如，
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7.发明申请METHOD FOR THE QUALITATIVE AND QUANTITATIVE ANALYSIS OF COMPLEX MIXTURES OF CHEMICAL COMPOUNDS, USING MALDI-TOF MASS SPECTROMETRY 审中-公开复杂混合物的定量分析方法和化合物MALDI-TOF质谱的质量
公开(公告)号：WO0194910A3
公开(公告)日：2003-10-02
申请号：PCT/EP0106415
申请日：2001-06-06
Applicant: BASF AG , HEINZLE ELMAR , WITTMANN CHRISTOPH
Inventor： HEINZLE ELMAR , WITTMANN CHRISTOPH
IPC: H01J49/04 , H01J49/16 , G01N33/483
CPC classification number: H01J49/164
Abstract: The invention relates to a method for the qualitative and quantitative analysis of complex mixtures of chemical compounds, using MALDI-TOF mass spectrometry, preferably in the presence of an internal standard on a special supporting material. The inventive method can be used in an advantageous manner to carry out biochemical flow analyses.
Abstract translation: 本发明涉及一种用于通过MALDI-TOF质谱法优选在内部标准的一个特殊的载体材料中存在的化学手段的化合物的复杂混合物的定性和定量分析的方法。 利用本发明的方法分析BIOFLUX可以有利地进行。
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公开(公告)号：NO20062494A
公开(公告)日：2006-09-06
申请号：NO20062494
申请日：2006-05-31
Applicant: BASF AG
Inventor： KROGER BURKHARD , ZELDER OSKAR , SCHRODER HARTWIG , HAFNER STEFAN , KIEFER PATRICK , WITTMANN CHRISTOPH , KLOPPROGGE CORINNA , HEINZLE ELMAR
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公开(公告)号：AR047057A1
公开(公告)日：2006-01-04
申请号：ARP040104740
申请日：2004-12-17
Applicant: BASF AG
Inventor： ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KROEGER BURKHARD , KIEFER PATRICK , HEINZLE ELMAR , WITTMANN CHRISTOPH
Abstract: Comprende métodos para aumentar la produccion de un compuesto químico fino, por ejemplo, lisina a partir de un microorganismo, por ejemplo, Corynebacterium mediante la desregulacion de un gen codificador de una enzima, es decir, lactato deshidrogenasa. Se proveen métodos para incrementar la produccion de lisina en Corynebacterium glutamicum a través del incremento de la expresion de la actividad de lactato deshidrogenasa. También se provee un proceso para la produccion de lisina a través de la regulacion del flujo de carbono hacia oxalacetato (OAA).Se proveen métodos para la produccion de lisina a través de la utilizacion de fructosa o sacarosa como fuente de carbono. Reivindicacion 1: Un método para aumentar el flujo metabolico a través de la vía de pentosafosfatos en un microorganismo que comprenda el cultivo de dicho microorganismo que contenga un gen que se desregula bajo condiciones tales que se aumenta el flujo metabolico a través de la vía de pentosafosfatos. Reivindicacion 49: Un microorganismo recombinante que comprende un gen de biosíntesis de pentosafosfato desregulado
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公开(公告)号：AU2004299729A1
公开(公告)日：2005-06-30
申请号：AU2004299729
申请日：2004-12-17
Applicant: BASF AG
Inventor： KIEFER PATRICK , KLOPPROGGE CORINNA , WITTMANN CHRISTOPH , HAFNER STEFAN , HEINZLE ELMAR , ZELDER OSKAR , KROGER BURKHARD , SCHRODER HARTWIG
Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
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