公开(公告)号：BR0313760A

公开(公告)日：2005-07-12

申请号：BR0313760

申请日：2003-08-26

Applicant: BASF AG

Inventor： GER BURKHARD KR ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  DER HARTWIG SCHR ,  HOFNER STEFAN

IPC: A23K1/00 ,  A23K1/16 ,  C12N15/09 ,  C12P13/04 ,  C12P13/12 ,  C12R1/15

Abstract: Fermentative production of at least one sulfur-containing fine chemical (I) by fermenting a (I)-producing coryneform bacterium (A), concentrating (I) in medium or cells, then isolating it. (A) expresses at least one heterologous nucleotide sequence (II) that encodes a protein (III) with methionine synthase (metF) activity. An Independent claim is also included for preparation of a feed additive (B) that contains L-methionine by culturing/fermenting an L-Met producing microorganisms, removing water from the fermentation broth and optionally also up to 100 % of the biomass, then drying the treated broth to recover (B) in powdered or granular form.

公开(公告)号：BR0317507A

公开(公告)日：2005-11-16

申请号：BR0317507

申请日：2003-12-19

Applicant: BASF AG

Inventor： KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  HOFNER STEFAN ,  LIEBL WOLFGANG

IPC: C12P13/04

Abstract: The invention relates to a method for producing an amino acid comprising culturing a microorganism of the genus Corynebacterium or Brevibacterium wherein said microorganism is partially or completely deficient in at least one of the gene loci of the the group which is formed by otsAB, treZ and treS, and subsequent isolation of the amino acid from the culture medium.

公开(公告)号：BR0311142A

公开(公告)日：2005-03-01

申请号：BR0311142

申请日：2003-05-23

Applicant: BASF AG

Inventor： DER HARTWIG SCHR ,  GER BURKHARD KR ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  HOFNER STEFAN

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/10 ,  C12P13/12 ,  C12R1/15 ,  C12P11/00

Abstract: The invention relates to methods for the production of sulfur-containing fine chemicals, in particular L-methionine, by fermentation using bacteria in which a nucleotide sequence encoding an S-adenosylmethionine synthase (metK) gene is expressed.

公开(公告)号：BR0313759A

公开(公告)日：2005-06-21

申请号：BR0313759

申请日：2003-08-26

Applicant: BASF AG

Inventor： GER BURKHARD KR ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  DER HARTWIG SCHR ,  HOFNER STEFAN

IPC: A23K1/00 ,  A23K1/16 ,  C12N15/09 ,  C12P13/04 ,  C12P13/12

Abstract: Method for fermentative production of at least one sulfur-containing fine chemical (I) by fermenting a (I)-producing coryneform bacterium (A); concentrating (I) in medium or cells, then isolating it. (A) expresses at least one heterologous nucleotide sequence (II) that encodes a protein (III) with homoserine O-acetyltransferase (metA) activity. An Independent claim is also included for preparation of a feed additive (B) that contains L-methionine by culturing/fermenting an L-Met producing microorganisms; removing water from the fermentation broth and optionally also up to 100% of the biomass, then drying the treated broth to recover (B) in powdered or granular form.

公开(公告)号：BR0313758A

公开(公告)日：2005-06-21

申请号：BR0313758

申请日：2003-08-26

Applicant: BASF AG

Inventor： GER BURKHARD KR ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  DER HARTWIG SCHR ,  HOFNER STEFAN

IPC: A23K1/00 ,  A23K1/16 ,  C12N15/09 ,  C12P13/04 ,  C12P13/12 ,  C12R1/15

Abstract: Method for fermentative production of at least one sulfur-containing fine chemical (I) by fermenting a (I)-producing coryneform bacterium (A); concentrating (I) in medium or cells, then isolating it. (A) expresses at least one heterologous nucleotide sequence (II) that encodes a protein (III) with O-acetylhomoserine-sulfhydrolase (metY) activity. An Independent claim is also included for preparation of a feed additive (B) that contains L-methionine by culturing/fermenting an L-Met producing microorganisms; removing water from the fermentation broth and optionally also up to 100% of the biomass, then drying the treated broth to recover (B) in powdered or granular form.

公开(公告)号：BRPI0417773A

公开(公告)日：2007-03-20

申请号：BRPI0417773

申请日：2004-12-17

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  SCHROEDER HARTWIG ,  HOFNER STEFAN ,  KRUEGER BURKHARD ,  KIEFER PATRICK ,  HEINZLE ELMAR ,  WITTMANN CHRISTOPH

IPC: C12N9/04 ,  C12P13/08 ,  C12P13/00

Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., lactate dehydrogenase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of the expression of lactate dehydrogenase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.