公开(公告)号：AT77739T

公开(公告)日：1992-07-15

申请号：AT87104724

申请日：1987-03-31

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT DR ,  KLIMESCH ROGER GUENTHER DR ,  LAEMMERHIRT KLAUS DR ,  LANG SIEGFRIED DR ,  SANNER AXEL DR ,  SPENGLER REINHARD DR

IPC: A61K47/32 ,  A61J3/06 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K47/00

公开(公告)号：DE3769687D1

公开(公告)日：1991-06-06

申请号：DE3769687

申请日：1987-03-31

Applicant: BASF AG

Inventor： KLIMESCH ROGER GUENTHER DR ,  BLECKMANN GERHARD ,  FARWERCK KARL-PETER ,  GOERTZ HANS-HELMUT DR ,  SCHLEMMER LOTHAR

IPC: A61H39/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  B29B9/06 ,  B30B11/16 ,  B30B11/24

Abstract: Extrudable pharmaceutical mixtures are tableted by a continuous method in which the mixture is extruded and the still deformable extrudate is pressed between two rollers which are driven in opposite directions and possess depressions opposite one another in the roller shell, the form of these depressions determining the tablet shape.

公开(公告)号：GR3002559T3

公开(公告)日：1993-01-25

申请号：GR910400710

申请日：1991-06-03

Applicant: BASF AG

Inventor： KLIMESCH ROGER GUENTHER DR ,  BLECKMANN GERHARD ,  FARWERCK KARL-PETER ,  GOERTZ HANS-HELMUT DR ,  SCHLEMMER LOTHAR

IPC: A61H39/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  B29B9/06 ,  B30B11/16 ,  B30B11/24

Abstract: Extrudable pharmaceutical mixtures are tableted by a continuous method in which the mixture is extruded and the still deformable extrudate is pressed between two rollers which are driven in opposite directions and possess depressions opposite one another in the roller shell, the form of these depressions determining the tablet shape.

公开(公告)号：DE3780059D1

公开(公告)日：1992-08-06

申请号：DE3780059

申请日：1987-03-31

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT DR ,  KLIMESCH ROGER GUENTHER DR ,  LAEMMERHIRT KLAUS DR ,  LANG SIEGFRIED DR ,  SANNER AXEL DR ,  SPENGLER REINHARD DR

IPC: A61K47/32 ,  A61J3/06 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K47/00

Abstract: Prodn. of solid pharmaceutical dosage forms is effected by mixing at least one active ingredient with at least one meltable binder andopt. other additives, and either injection moulding or extruding and shaping the mxit. at 50-180 deg.C.. The binder is a solvent free polymer of N-vinylpyrrolidone (NVP) comprising 20-100 wt.% NVP and 0-80 wt.% of N- and/or O-contg. comonomers. The polymer contains no more than 3.5 wt.% H2O.At least when the mxit. has a glass temp. above 130 deg.C, the polymer must be produced by polymerisation in an organic solvent or by polymerisation in an aq. medium using an organic peroxide initiator. The mixt. contains no added thermoplasts which are sparingly soluble in gastric juices.

公开(公告)号：AT63056T

公开(公告)日：1991-05-15

申请号：AT87104731

申请日：1987-03-31

Applicant: BASF AG

Inventor： KLIMESCH ROGER GUENTHER DR ,  BLECKMANN GERHARD ,  FARWERCK KARL-PETER ,  GOERTZ HANS-HELMUT DR ,  SCHLEMMER LOTHAR

IPC: A61H39/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  B29B9/06 ,  B30B11/16 ,  B30B11/24