公开(公告)号：AT287877T

公开(公告)日：2005-02-15

申请号：AT02016604

申请日：2002-07-25

Applicant: BASF AG

Inventor： RUST HARALD ,  BURKART KIRSTEN ,  FAUST TILLMANN DR ,  HENKELMANN JOCHEM DR ,  KINDLER ALOIS DR ,  KNOLL CHRISTIAN DR ,  BECKER MICHAEL DR

IPC: C07D213/67 ,  C07D263/42

公开(公告)号：DE50211588D1

公开(公告)日：2008-03-13

申请号：DE50211588

申请日：2002-07-26

Applicant: BASF AG

Inventor： RUST HARALD ,  BURKART KIRSTEN ,  FAUST TILLMANN DR ,  HENKELMANN JOCHEM DR ,  KINDLER ALOIS DR ,  KNOLL CHRISTIAN DR ,  MOHRY ANDRE DR

IPC: C07D263/42

Abstract: Continuous production of 5-alkoxy oxazoles (I) comprises heating an alkyl alpha -isocyanoalkanoate ester (II) at a temperature above 80 degrees C in the presence of an auxiliary agent and withdrawing the product from the reactor. Continuous production of 5-alkoxy oxazoles of formula (I) comprises heating an alkyl alpha -isocyanoalkanoate ester of formula (II) at a temperature above 80 degrees C in the presence of an auxiliary agent and withdrawing the product from the reactor. R1 = optionally substituted 1-6C alkyl; R2 = H or optionally substituted 1-6C alkyl. An Independent claim is also included for a process for producing pyridoxine derivatives of formula (IX), comprising: (1) converting an amino acid of formula (III) to an ester of formula (IV); (2) converting (IV) to a formamido ester of formula (IV); (3) converting (IV) to (II); (4) converting (II) to (I) as above; (5) reacting (I) with a protected diol of formula (VI) to form a Diels-Alder adduct of formula (VII); and (6) converting (VII) to (IX) by acid treatment and deprotection. R3, R4 = protecting groups or together form a protecting group.