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公开(公告)号:JP2003261546A
公开(公告)日:2003-09-19
申请号:JP2002355604
申请日:2002-12-06
Applicant: BASF AG
Inventor: RUST HARALD , BURKART KIRSTEN , FAUST TILLMANN , HENKELMANN JOCHEM , KINDLER ALOIS , KNOLL CHRISTIAN , MOHRY ANDRE
IPC: C07D213/66 , B01D3/14 , B01J14/00 , C07D213/67 , C07D263/42
Abstract: PROBLEM TO BE SOLVED: To provide a new process for the continuous preparation of a 5- alkoxy-substituted oxazole in high yield and high space-time yield. SOLUTION: The process for the continuous preparation of a 5-alkoxy- substituted oxazole of formula I (R 1 is a substituted or unsubstituted 1-6C alkyl; and R 2 is H or a substituted or unsubstituted 1-6C alkyl) comprises the conversion of a continuously charged α-isocyanoalkanoic acid ester of formula II to the 5-alkoxy-substituted oxazole of formula I in a reactor at ≥80°C in the presence of an assistant selected from continuously charged alcohols and esters and the continuous discharge of the reaction product from the reactor. COPYRIGHT: (C)2003,JPO
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公开(公告)号:JP2001114711A
公开(公告)日:2001-04-24
申请号:JP2000307760
申请日:2000-10-06
Applicant: BASF AG
Inventor: KRATZ DETLEF DR , RUST HARALD , KROKOSZINSKI ROLAND , HELF VOLKER
IPC: C07C29/141 , C07C29/16 , C07C31/20 , C07C45/50 , C07C45/72
Abstract: PROBLEM TO BE SOLVED: To provide a method for easily and economically producing an 1,3-diol. SOLUTION: This method comprises the following steps: (a) at least one kind of >=3C alkanal is prepared, (b) the alkanal is heat-treated in the absence of a basic catalyst, (c) the resultant aldol addition product is hydrogenated, and (d) the objective 1,3-diol thus produced is collected. This 1,3-diol has >=6 carbon atoms in the molecule.
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公开(公告)号:JP2000169408A
公开(公告)日:2000-06-20
申请号:JP34913799
申请日:1999-12-08
Applicant: BASF AG
Inventor: RAHN RALF-THOMAS , RUST HARALD , RUEHL THOMAS DR , HENKELMANN JOCHEM DR , STUTZ SUSANNE DR
IPC: C07C29/82 , C07C29/16 , C07C29/80 , C07C33/025 , C07C33/042 , C07C33/048
Abstract: PROBLEM TO BE SOLVED: To provide a continuous distillation method having excellent economic efficiency, guaranteeing safety of high level in the case of isolating α- ethynylcarbinol on an industrial scale. SOLUTION: α-Ethynylcarbinol is isolated from a liquid reaction mixture obtained by adding acetylene to an α,β-unsaturated carbonyl compound by a continuous distillation comprising introducing a feed stream to the central part of a distillation column, azeotropically distilling away most of water together with a solvent at the top of the column and taking out α- ethynylcarbinol of the objective product at a part below the feeding part to the column.
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公开(公告)号:JP2003267958A
公开(公告)日:2003-09-25
申请号:JP2002355822
申请日:2002-12-06
Applicant: BASF AG
Inventor: RUST HARALD , BURKART KIRSTEN , FAUST TILLMANN , HENKELMANN JOCHEM , KINDLER ALOIS , KNOLL CHRISTIAN , BECKER MICHAEL
IPC: B01D3/14 , B01J14/00 , C07D213/67 , C07D263/42
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a 5-alkoxy-substituted oxazole, especially a 4-methyl-5-alkoxy-substituted oxazole and further a method for producing a pyridoxine derivative. SOLUTION: The method for producing the substituted oxazole is carried out as follows. An α-isocyanoalkanoic acid ester is converted into the 5-alkoxy- substituted oxazole in the presence of an assistant composed of an alcohol or an ester at >80°C. The resultant 5-alkoxy-substituted oxazole is taken out of the reactional mixture simultaneously with the conversion. COPYRIGHT: (C)2003,JPO
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公开(公告)号:JP2003201283A
公开(公告)日:2003-07-18
申请号:JP2002227742
申请日:2002-08-05
Applicant: BASF AG
Inventor: RUST HARALD , BURKART KIRSTEN , FAUST TILLMANN , HENKELMANN JOCHEM , KINDLER ALOIS , KNOLL CHRISTIAN , MOHRY ANDRE
IPC: C07D213/67 , C07D263/42
Abstract: PROBLEM TO BE SOLVED: To provide a method for continuously producing a 5-alkoxy-substituted oxazole and a method for producing a pyridoxine derivative by using the same. SOLUTION: This method for obtaining a pyridoxine derivative is provided by converting an α-isocyanoalkanoic acid ester expressed by the formula II in the presence of continuously supplied base at ≥80°C temperature to a 5- alkoxy-substituted oxazole I, taking it out from a reactor at the same time with the reaction, performing a reaction of the compound I with a compound VI to make a compound VII, and acid-treating it to obtain a pyridoxine derivative IX (in formulae, R 1 is an alkyl, R 2 is H or an alkyl, R 3 , R 4 are each independently a protection group of hydroxy group). COPYRIGHT: (C)2003,JPO
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公开(公告)号:JP2003176272A
公开(公告)日:2003-06-24
申请号:JP2002227292
申请日:2002-08-05
Applicant: BASF AG
Inventor: RUST HARALD , BURKART KIRSTEN , FAUST TILLMANN , HENKELMANN JOCHEM , KINDLER ALOIS , KNOLL CHRISTIAN , BECKER MICHAEL
IPC: C07D233/70 , C07D213/67 , C07D263/42
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a 5-alkoxy-substituted oxazole and a method for producing a pyridoxine derivative. SOLUTION: The 5-alkoxy-substituted oxazole is obtained by converting an α-isocyano alkylic acid ester in the presence of a base at >80°C and separating the 5-alkoxy-substituted oxazole from the reaction mixture simultaneously with the converting reaction, and the pyridoxine derivative is obtained by converting an amino acid into an amino acid ester, converting the obtained into a formamido acid ester, converting the obtained into an α-isocyanoalkyl acid ester, converting the obtained into a 5-alkoxy-substituted oxazole in the presence of a base at >80°C and separating the 5-alkoxy-substituted oxazole from the reaction mixture simultaneously with the converting reaction, reacting the obtained 5-alkoxy-substituted oxazole with a protective diol to obtain an Diels-Alder adduct and treating the obtained with an acid and removing the protective group to convert into the pyridoxine derivative. COPYRIGHT: (C)2003,JPO
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公开(公告)号:MY136889A
公开(公告)日:2008-11-28
申请号:MYPI20015864
申请日:2001-12-24
Applicant: BASF AG
Inventor: GALL MARTIN , KAIBEL GERD DR , KRUG THOMAS , RUST HARALD , STEIN FRANK DR
IPC: C07D309/30 , B01D3/14 , C07C29/80 , C07C31/20 , C07D315/00
Abstract: A PROCESS FOR WORKING UP BY DISTILLATION THE CRUDE PRODUCTS OBTAINED IN THE PROCESS ACCORDING TO DE-A 196 07 954 AND CONTAINING 1,6-HEXANIDIOL (HDO),1,5-PENTANIDIOL (PDO) OR CAPROLACTONE (CLO) IN ORDER IN OBTAIN THE CORESPONDING PURE PRODUCTS,THE WORKING-UP BY DISTILLATION BEONG CARIED OUT IN EACH CASE IN A DIVIDING WALL COLUMN (TK) IN WHICH A DIVIDING WALL (T) IS ARRANGED IN THE LOGITUDINAL DIRECTION OF DIRECTION OF THE COLUMN WITH FORMATION OF AN UPPER COMMON COLUMN REGION (1),A LOWER COMMON COLUMN REGION (6),A FEED SECTION (2,4) HAVING A RECTIFICATION SECTION (2) AND STRIPPING SECTION (4) AND A TAKE-OFF SECTION (3,5) HAVING A STRIPPING SECTION (3) AND RETIFICATION SECTION (5),WITH FEEDING OF THE RESPECTIVE CRUDE PRODUCT HDO,PLO OR CLO IN THE MIDDLE REGION OF THE FEED SECTION (2,4) AND REMOVAL OF THE HIGH BOILER FRACTION (C) FROM THE BOTTOM OF THE COLUMN,OF THE LOW BOILER FRACTION (A) VIA THE TOP OF COLUMN AND OF THE MEDIUM BOILRE FRACTION (B) FROM THR MIDDLE REGION OF THE TAKE-OFF SECTION (3,5),OR IN THERMALLY COUPLED COLUMNS.
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公开(公告)号:AT384706T
公开(公告)日:2008-02-15
申请号:AT02016707
申请日:2002-07-26
Applicant: BASF AG
Inventor: RUST HARALD , BURKART KIRSTEN , FAUST TILLMANN , HENKELMANN JOCHEM , KINDLER ALOIS , KNOLL CHRISTIAN , MOHRY ANDRE
IPC: C07D263/42
Abstract: Continuous production of 5-alkoxy oxazoles (I) comprises heating an alkyl alpha -isocyanoalkanoate ester (II) at a temperature above 80 degrees C in the presence of an auxiliary agent and withdrawing the product from the reactor. Continuous production of 5-alkoxy oxazoles of formula (I) comprises heating an alkyl alpha -isocyanoalkanoate ester of formula (II) at a temperature above 80 degrees C in the presence of an auxiliary agent and withdrawing the product from the reactor. R1 = optionally substituted 1-6C alkyl; R2 = H or optionally substituted 1-6C alkyl. An Independent claim is also included for a process for producing pyridoxine derivatives of formula (IX), comprising: (1) converting an amino acid of formula (III) to an ester of formula (IV); (2) converting (IV) to a formamido ester of formula (IV); (3) converting (IV) to (II); (4) converting (II) to (I) as above; (5) reacting (I) with a protected diol of formula (VI) to form a Diels-Alder adduct of formula (VII); and (6) converting (VII) to (IX) by acid treatment and deprotection. R3, R4 = protecting groups or together form a protecting group.
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公开(公告)号:DE102005048250A1
公开(公告)日:2007-04-12
申请号:DE102005048250
申请日:2005-10-07
Applicant: BASF AG
Inventor: PINKOS ROLF , RUST HARALD , TEBBEN GERD-DIETER , HAUK ALEXANDER , MUELLER CHRISTIAN
IPC: C07C45/27 , C07B63/02 , C07C2/44 , C07C5/05 , C07C13/275 , C07C13/277 , C07C29/149 , C07D301/03 , C07D303/04
Abstract: The present invention relates to a process for purifying a composition (I) at least comprising cyclododecanone. The process according to the invention for purifying a composition (I) at least comprising cyclododecanone comprises at least step (i) (i) irradiation of the composition (I).
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公开(公告)号:ES2266015T3
公开(公告)日:2007-03-01
申请号:ES00985231
申请日:2000-12-21
Applicant: BASF AG
Inventor: DERNBACH MATTHIAS , KRATZ DETLEF , STAMMER ACHIM , RUST HARALD , SCHULZ GERHARD
IPC: C07C29/80 , C07B61/00 , C07C29/141 , C07C31/22
Abstract: Procedimiento para la destilación de purificación de trimetilolpropano procedente de la hidrogenación de 2, 2-dimetilolbutanal, que presenta las etapas siguientes: a) reacción de n-butiraldehído con formaldehído en presencia de cantidades catalíticas de una amina terciaria e hidrogenación de la mezcla obtenida de este modo para dar una mezcla que contiene trimetilolpropano; b) separación por destilación del agua, del metanol, de la trialquilamina y/o del formiato de trialquilamonio a presiones > 200 mbares, preferentemente > 400 mbares, temperaturas en la cola > 140ºC, preferentemente desde 160 hasta 180ºC, así como tiempos de residencia prolongados, que se lleva a cabo de tal manera que al menos la parte preponderante del TMP con el formiato de trialquilamonio, formado en la etapa (a) reaccione para dar formiatos de TMP que permanecen en la cola y trialquilamina que se elimina por destilación con agua y con metanol, c) calentamiento del residuo, obtenido en b) en vacío a una temperatura,a la que sea volátil el trimetilolpropano y se disocien al menos parcialmente los compuestos con un punto de ebullición mayor que el del trimetilolpropano, con separación mediante destilación del trimetilolpropano así como de los compuestos más fácilmente volátiles que el trimetilolpropano; d) destilación del destilado, obtenido en c) y separación de los compuestos fácilmente volátiles y obtención de TMP puro; e) destilación facultativa del trimetilolpropano, obtenido en d), para la obtención de TMP con un menor índice de color APHA.
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