公开(公告)号：DK502988A

公开(公告)日：1989-03-11

申请号：DK502988

申请日：1988-09-09

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS ,  KREIMEYER ANDREAS ,  DAUM LOTHAR

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K1/22 ,  C07K14/52 ,  C07K14/525 ,  C07K14/555 ,  C07K14/57 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  C07K13/00 ,  C07H21/04 ,  C07K15/26 ,  C12N15/00

公开(公告)号：DE59007173D1

公开(公告)日：1994-10-20

申请号：DE59007173

申请日：1990-12-20

Applicant: BASF AG

Inventor： LANG KURT ,  KREIMEYER ANDREAS

IPC: C12N15/09 ,  C07D475/04 ,  C07K1/30 ,  C07K14/815 ,  C12N9/00 ,  C12N9/76 ,  C12N15/15 ,  C12P21/00 ,  C12P21/02 ,  C12R1/19 ,  C07K3/24

Abstract: PCT No. PCT/EP91/02269 Sec. 371 Date Jul. 17, 1992 Sec. 102(e) Date Jul. 17, 1992 PCT Filed Dec. 20, 1990 PCT Pub. No. WO91/10677 PCT Pub. Date Jul. 25, 1991.A method for the concentration and purification of biomolecules is described and comprises introducing the biomolecule into an aqueous/organic solvent system and bringing about a phase separation by addition of salts, where the pH at which the concentration takes place, the solvents suitable for the aqueous/organic solvent system, and the nature of the salt are determined in a series of tests one embodiment concerns concentration of hirudin by using propanol, butanol or acetone a the solvent and sodium chloride as the salt.

公开(公告)号：DK502988D0

公开(公告)日：1988-09-09

申请号：DK502988

申请日：1988-09-09

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS ,  KREIMEYER ANDREAS ,  DAUM LOTHAR

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K1/22 ,  C07K14/52 ,  C07K14/525 ,  C07K14/555 ,  C07K14/57 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  C07K13/00 ,  C07H21/04 ,  C07K15/26 ,  C12N15/00

公开(公告)号：AT111481T

公开(公告)日：1994-09-15

申请号：AT91900759

申请日：1990-12-20

Applicant: BASF AG

Inventor： LANG KURT ,  KREIMEYER ANDREAS

IPC: C12N15/09 ,  C07D475/04 ,  C07K1/30 ,  C07K14/815 ,  C12N9/00 ,  C12N9/76 ,  C12N15/15 ,  C12P21/00 ,  C12P21/02 ,  C12R1/19 ,  C07K3/24

Abstract: PCT No. PCT/EP91/02269 Sec. 371 Date Jul. 17, 1992 Sec. 102(e) Date Jul. 17, 1992 PCT Filed Dec. 20, 1990 PCT Pub. No. WO91/10677 PCT Pub. Date Jul. 25, 1991.A method for the concentration and purification of biomolecules is described and comprises introducing the biomolecule into an aqueous/organic solvent system and bringing about a phase separation by addition of salts, where the pH at which the concentration takes place, the solvents suitable for the aqueous/organic solvent system, and the nature of the salt are determined in a series of tests one embodiment concerns concentration of hirudin by using propanol, butanol or acetone a the solvent and sodium chloride as the salt.

公开(公告)号：AU4344789A

公开(公告)日：1990-05-01

申请号：AU4344789

申请日：1989-10-04

Applicant: BASF AG

Inventor： RETTENMAIER HANSJORG ,  PERNER JOHANNES ,  DIESSEL PAUL ,  KREIMEYER ANDREAS

IPC: C11D3/386 ,  C12N9/54 ,  C12N1/20

Abstract: PCT No. PCT/EP89/01163 Sec. 371 Date May 29, 1990 Sec. 102(e) Date May 29, 1990 PCT Filed Oct. 4, 1989 PCT Pub. No. WO90/04022 PCT Pub. Date Apr. 19, 1990.A substantially purified proteolytic enzyme isolated from a culture of Bacillus spec. DSM 4828 which has a molecular weight of 27,000 daltons, an optimum pH of 12, an optimal temperature of 60 DEG C. and which can be used in a detergent composition.

公开(公告)号：DK0511221T3

公开(公告)日：1994-10-17

申请号：DK91900759

申请日：1990-12-20

Applicant: BASF AG

Inventor： LANG KURT ,  KREIMEYER ANDREAS

IPC: C12N15/09 ,  C07D475/04 ,  C07K1/30 ,  C07K14/815 ,  C12N9/00 ,  C12N9/76 ,  C12N15/15 ,  C12P21/00 ,  C12P21/02 ,  C12R1/19 ,  C07K3/24

Abstract: PCT No. PCT/EP91/02269 Sec. 371 Date Jul. 17, 1992 Sec. 102(e) Date Jul. 17, 1992 PCT Filed Dec. 20, 1990 PCT Pub. No. WO91/10677 PCT Pub. Date Jul. 25, 1991.A method for the concentration and purification of biomolecules is described and comprises introducing the biomolecule into an aqueous/organic solvent system and bringing about a phase separation by addition of salts, where the pH at which the concentration takes place, the solvents suitable for the aqueous/organic solvent system, and the nature of the salt are determined in a series of tests one embodiment concerns concentration of hirudin by using propanol, butanol or acetone a the solvent and sodium chloride as the salt.

公开(公告)号：CA2067790A1

公开(公告)日：1991-07-19

申请号：CA2067790

申请日：1990-12-20

Applicant: BASF AG

Inventor： LANG KURT ,  KREIMEYER ANDREAS

IPC: C12N15/09 ,  C07D475/04 ,  C07K1/30 ,  C07K14/815 ,  C12N9/00 ,  C12N9/76 ,  C12N15/15 ,  C12P21/00 ,  C12P21/02 ,  C12R1/19

Abstract: 2067790 9110677 PCTABS00006 In a process for enriching or cleaning biomolecules, the biomolecule is introduced into an aqueous-organic solvent system and salts are added to separate the phases. The pH at which the enrichment is carried out, suitable solvents for the aqueous-organic system and the type of salt are determined in a series of tests.

公开(公告)号：ES2018734A6

公开(公告)日：1991-05-01

申请号：ES8903413

申请日：1989-10-10

Applicant: BASF AG

Inventor： REITTENMATER HANSJORG ,  KREIMEYER ANDREAS ,  PERNER JOHANNES ,  DIESSEL PAUL

IPC: C11D3/386 ,  C12N9/54 ,  C12N1/20

Abstract: PROCEDIMIENTO PARA LA OBTENCION DE UN ENZIMA PROTEOLITICO. COMPRENDE CULTIVAR EL MICROORGANISMO BACILLUS SPEC. DSM 4828 EN UN MEDIO NUTRIENTE Y AISLAR EL ENZIMA DEL CALDO DE CULTIVO. EL ENZIMA ASI OBTENIDO TIENE APLICACION EN LA FABRICACION DE DETERGENTES.

公开(公告)号：AU2203688A

公开(公告)日：1989-03-16

申请号：AU2203688

申请日：1988-09-09

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS ,  KREIMEYER ANDREAS ,  DAUM LOTHAR

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K1/22 ,  C07K14/52 ,  C07K14/525 ,  C07K14/555 ,  C07K14/57 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  C07G17/00 ,  C07H21/04 ,  C07K13/00 ,  C12N15/00