公开(公告)号：DE2910131A1

公开(公告)日：1980-09-25

申请号：DE2910131

申请日：1979-03-15

Applicant: BASF AG

Inventor： ROSS KARL-HEINZ DIPL CHEM DR ,  DUDECK CHRISTIAN DIPL CHEM DR ,  HIMMELE WALTER DIPL CHEM DR ,  LEBKUECHER ROLF DIPL CHEM DR ,  SAUER WOLFGANG DIPL CHEM DR

IPC: C07D303/14 ,  C07D307/20 ,  C07D307/32 ,  C07D307/60 ,  A61K7/46 ,  A23L2/26 ,  A23L1/235

Abstract: A process for the preparation of the sought-after scent 2,5-dimethyl-4-hydroxy-2,3-dihydrofuran-3-one, and novel intermediates for the preparation of this compound. 2,5-Dimethyl-4-hydroxy-2,3-dihydrofuran-3-one is prepared by first epoxidizing hex-3-ene-2,5-diol in the liquid phase with hydrogen peroxide to give the novel compound 3,4-epoxy-hexane-2,5-diol, which at 40 DEG -280 DEG C. is converted, by means of a catalytic amount of an acid, to the novel compound 2,5-dimethyl-3,4-dihydroxy-tetrahydro-furan. The latter is dehydrogenated by means of oxygen over a silver catalyst or copper catalyst to give the nove compound 2,5-dimethyl-4-hydroxy-tetrahydrofuran-3-one, which is oxidized by means of bismuth oxide, in concentrated acetic acid solution, to give the desired compound 2,5-dimethyl-4-hydroxy-2,3-dihydrofuran-3-one.