公开(公告)号：AU8732798A

公开(公告)日：1999-03-08

申请号：AU8732798

申请日：1998-07-25

Applicant: BASF AG

Inventor： BREUER MICHAEL ,  HAUER BERNHARD ,  MESCH KATHRIN ,  IDING HANS ,  GOETZ GUNTER ,  POHL MARTINA ,  KULA MARIA-REGINA

IPC: C12N9/88 ,  C12P7/26

公开(公告)号：DE19736104A1

公开(公告)日：1999-02-25

申请号：DE19736104

申请日：1997-08-20

Applicant: BASF AG

Inventor： BREUER MICHAEL DR ,  HAUER BERNHARD DR ,  MESCH KATHRIN ,  IDING HANS ,  GOETZ GUENTER ,  POHL MARTINA DR ,  KULA MARIA-REGINA PROF DR

IPC: C12N9/88 ,  C12P7/26 ,  C07C45/72 ,  C07C49/245

Abstract: Preparation of entantiomerically pure phenylacetycarbinol derivatives (I) from acetaldehyde and benzaldehyde is carried out in the presence of pyruvate decarboxylase, which is obtained from Zymomonas mobilis. Preparation of entantiomerically pure phenylacetycarbinol derivatives of formula (I) comprises reacting acetaldehyde with the corresponding benzaldehyde (II) in the presence of pyruvate decarboxylase obtained from Zymomonas. The novelty comprises continuous or discontinuous addition of acetaldehyde to the reaction mixture, to ensure that the acetaldehyde concentration stays at 20-50 mMol/l: R = H, F, Cl or Br.