公开(公告)号：WO2006087324A3

公开(公告)日：2007-03-01

申请号：PCT/EP2006050920

申请日：2006-02-14

Applicant: BASF AG ,  MOULIN DOMINIQUE ,  SIEGEL WOLFGANG ,  HUTTENLOCH OLIVER

Inventor： MOULIN DOMINIQUE ,  SIEGEL WOLFGANG ,  HUTTENLOCH OLIVER

IPC: C07C231/12 ,  C07C233/05

CPC classification number: C07C231/12 ,  C07C45/516 ,  C07C49/788 ,  C07C233/05

Abstract: The invention relates to a method for producing an N-(1-aryl-alk-1-enyl)-acetamide or N-(1-heteroaryl-alk-1-enyl)-acetamide. According to the invention, an N-(alk-1-enyl)-acetamide is reacted with an aryl- or heteroaryl-chloride, bromide, iodide or triflate in the presence of a) a Pd-catalyst and b) water and/or an ionic liquid, and c) dimethylformamide (DMF), N,N-dimethylacetamide (DMAC) and/or surplus N-(alk-1-enyl)-acetamide.

Abstract translation: 一种用于制备N-（1-芳基 - 烷-1-烯基） - 乙酰胺或N-（1 - 杂芳基链-1-烯基） - 乙酰胺，得到N-（ALK-I-烯基） - 乙酰胺处理 在a）一种钯催化剂的存在下用芳基或杂芳基氯化物，溴化物，碘化物，或三氟甲磺酸酯，和b）水和/或离子液体，和c）二甲基甲酰胺（DMF），N，N-二甲基乙酰胺（DMAC）和 /或过量的N-（烷-1-烯基） - 乙酰胺反应。

公开(公告)号：DE102005052847A1

公开(公告)日：2007-05-10

申请号：DE102005052847

申请日：2005-11-05

Applicant: BASF AG

Inventor： MOULIN DOMINIQUE ,  SIEGEL WOLFGANG ,  HUTTENLOCH OLIVER

IPC: C07C331/12 ,  B01J31/22 ,  C07B37/04 ,  C07B41/06 ,  C07C49/76 ,  C07C49/788 ,  C07C233/01 ,  C07D213/40

Abstract: Preparation of N-(1-aryl-alk-1-enyl)-acetamide or N-(1-heteroaryl-alk-1-enyl)-acetamide comprises reaction of N-(alk-1-enyl)-acetamide with aryl- or heteroaryl- chloride, bromide, iodide or triflate in the presence of palladium-catalyst, water and/or ionic liquid, and dimethylformamide, N,N-dimethylacetamide and/or surplus N-(alk-1-enyl)-acetamide. Independent claims are included for: (1) a preparation of a ketone, comprising preparing N-(1-aryl-alk-1-enyl)-acetamide or N-(1-heteroaryl-alk-1-enyl)-acetamide and followed by hydrolyzing the acetamide; and (2) preparation of N-(1-aryl-alk-1-enyl)-acetamide or N-(1-heteroaryl-alk-1-enyl)-acetamide comprising preparing N-(1-aryl-alk-1-enyl)-acetamide or N-(1-heteroaryl-alk-1-enyl)-acetamide and reducing the acetamide or in situ.

公开(公告)号：DE102006001160A1

公开(公告)日：2007-07-12

申请号：DE102006001160

申请日：2006-01-06

Applicant: BASF AG

Inventor： DITRICH KLAUS ,  WINSEL HARALD ,  MOULIN DOMINIQUE

IPC: C07C229/38 ,  C07C227/34 ,  C12P41/00

Abstract: Producing optically active 4-(1-ammoniumethyl)-benzoic acid methylester-sulfate (I) comprises reacting racemic 4-(1-aminoethyl)-benzoic acid methyl ester with an acylating agent in the presence of a lipase to form 4-(1-aminoethyl)benzoic acid methyl ester and subsequently adding sulfuric acid to precipitate 4-(1-ammoniumethyl)-benzoic acid methyl ester-sulfate. An independent claim is included for (I), which is obtained by the above process.

公开(公告)号：DE102005006985A1

公开(公告)日：2006-08-17

申请号：DE102005006985

申请日：2005-02-15

Applicant: BASF AG

Inventor： MOULIN DOMINIQUE ,  SIEGEL WOLFGANG ,  HUTTENLOCH OLIVER

IPC: C07C231/12

Abstract: Preparation of N-(1-aryl-alk-1-enyl)-acetamides or N-(1-heteroaryl-alk-1-enyl)-acetamides comprises reaction of N-(alk-1-enyl)-acetamide with aryl or heteroaryl chloride, bromide, iodide or triflate in the presence of: (a) palladium-catalyst; (b) water and/or ionic liquid; and (c) dimethylformamide, N,N-dimethylacetamide and/or excess N-(alk-1-enyl)-acetamide. Independent claims are included for the following: (1) preparation of a ketone comprising preparing N-(1-aryl-alk-1-enyl)-acetamide or N-(1-heteroaryl-alk-1-enyl)-acetamide as above followed by hydrolysis of the acetamide; and (2) preparation of N-(1-aryl-alkyl)-acetamide or N-(1-heteroaryl-alkyl)-acetamide comprising preparing N-(1-aryl-alk-1-enyl)-acetamide or N-(1-heteroaryl-alk-1-enyl)-acetamide as above and subsequently reducing the acetamide or in situ.

公开(公告)号：DE102005062966A1

公开(公告)日：2007-07-05

申请号：DE102005062966

申请日：2005-12-28

Applicant: BASF AG

Inventor： DITRICH KLAUS ,  WINSEL HARALD ,  MOULIN DOMINIQUE

IPC: C07C229/38 ,  C07C227/34 ,  C12P13/04 ,  C12P41/00

Abstract: Production of optically active 4-(ammonium ethyl) benzoic acid methyl ester-sulfate (I) comprises reacting a racemic mixture of 4-(1-aminoethyl)-benzoic acid methyl ester with an acylating agent in the presence of lipase to give 4-(aminoethyl) benzoic acid methyl ester and subsequently precipitating 4-(ammonium ethyl)benzoic acid methyl ester-sulfate by adding sulfuric acid. Independent claims are included for: (1) (S)-4-(ammonium ethyl) benzoic acid methyl ester sulfate; and (2) (R)-4-(ammonium ethyl) benzoic acid methyl ester sulfate.