公开(公告)号：JP2002338530A

公开(公告)日：2002-11-27

申请号：JP2002100061

申请日：2002-04-02

Applicant: BASF AG

Inventor： WINSEL HARALD ,  SIEGEL WOLFGANG DR ,  BARTSCH MICHAEL

IPC: C07B61/00 ,  C07C209/52 ,  C07C211/27 ,  C07C211/30 ,  C07C213/02 ,  C07C217/58 ,  C07C249/02 ,  C07C251/24

Abstract: PROBLEM TO BE SOLVED: To provide a simpler process for preparing N-benzylamine. SOLUTION: This process for preparing the N-benzylamine comprises (i) in a first step, reacting benzaldehyde with a primary amine and providing an imine and (ii) in a second step, hydrogenating the imine with hydrogen in the presence of a catalyst containing one or more kinds of metals of groups 8 to 10 of the periodic table of elements and affording the N-benzylamine, wherein the imination (i) is carried out in a water-miscible solvent without removing formed water of reaction and the hydrogenation (ii) is carried out in the imine solution obtained by the imination (i) and containing the water of reaction.

公开(公告)号：DE102006001160A1

公开(公告)日：2007-07-12

申请号：DE102006001160

申请日：2006-01-06

Applicant: BASF AG

Inventor： DITRICH KLAUS ,  WINSEL HARALD ,  MOULIN DOMINIQUE

IPC: C07C229/38 ,  C07C227/34 ,  C12P41/00

Abstract: Producing optically active 4-(1-ammoniumethyl)-benzoic acid methylester-sulfate (I) comprises reacting racemic 4-(1-aminoethyl)-benzoic acid methyl ester with an acylating agent in the presence of a lipase to form 4-(1-aminoethyl)benzoic acid methyl ester and subsequently adding sulfuric acid to precipitate 4-(1-ammoniumethyl)-benzoic acid methyl ester-sulfate. An independent claim is included for (I), which is obtained by the above process.

公开(公告)号：DE102005062966A1

公开(公告)日：2007-07-05

申请号：DE102005062966

申请日：2005-12-28

Applicant: BASF AG

Inventor： DITRICH KLAUS ,  WINSEL HARALD ,  MOULIN DOMINIQUE

IPC: C07C229/38 ,  C07C227/34 ,  C12P13/04 ,  C12P41/00

Abstract: Production of optically active 4-(ammonium ethyl) benzoic acid methyl ester-sulfate (I) comprises reacting a racemic mixture of 4-(1-aminoethyl)-benzoic acid methyl ester with an acylating agent in the presence of lipase to give 4-(aminoethyl) benzoic acid methyl ester and subsequently precipitating 4-(ammonium ethyl)benzoic acid methyl ester-sulfate by adding sulfuric acid. Independent claims are included for: (1) (S)-4-(ammonium ethyl) benzoic acid methyl ester sulfate; and (2) (R)-4-(ammonium ethyl) benzoic acid methyl ester sulfate.

公开(公告)号：DE102004033718A1

公开(公告)日：2006-02-16

申请号：DE102004033718

申请日：2004-07-13

Applicant: BASF AG

Inventor： GRIESBACH ULRICH ,  WINSEL HARALD ,  PUETTER HERMANN

IPC: C25B3/25

Abstract: Process for preparing primary amines having a cyclopropyl unit and a primary amino group bound to an aliphatic or cycloaliphatic carbon atom (amine A) by cathodically reducing oximes having a cyclopropyl unit or oxime derivatives in which the hydrogen atom in the oxime group has been replaced by an alkyl or acyl group (oxime O) at a temperature of from 50 to 100° C. in an essentially anhydrous electrolyte solution in a divided electrolysis cell.

公开(公告)号：DE10116816A1

公开(公告)日：2002-10-17

申请号：DE10116816

申请日：2001-04-04

Applicant: BASF AG

Inventor： WINSEL HARALD ,  SIEGEL WOLFGANG ,  BARTSCH MICHAEL

IPC: C07B61/00 ,  C07C209/52 ,  C07C211/27 ,  C07C211/30 ,  C07C213/02 ,  C07C217/58 ,  C07C249/02 ,  C07C251/24 ,  C07C209/60

Abstract: Preparation of N-benzylamines by reacting benzaldehydes with primary amines to give imines and then hydrogenating the imines using hydrogen and a catalyst containing a Group 8-10 metal is such that the imination is effected in a water-miscible solvent and hydrogenation is effected without removal of the water produced in the imination.