公开(公告)号：DE3202125A1

公开(公告)日：1983-07-28

申请号：DE3202125

申请日：1982-01-23

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DIPL CHE ,  TRAUTMANN WALTER DIPL CHEM DR ,  NUERRENBACH AXEL DIPL CHEM DR

IPC: C07C29/14 ,  C07F9/54 ,  C07C121/64 ,  C07C121/75

Abstract: Tetralin or indan derivatives of the general formula (I) in which R and R denote hydrogen or a methyl group, R denotes hydrogen, an alkyl group having up to four carbon atoms or an alkoxy group having up to three carbon atoms, R denotes a short-chain alkyl group, such as a methyl or ethyl group, and A denotes a methylene or ethyl radical which may be further substituted by alkyl groups, preferably a methyl group, and their preparation.

公开(公告)号：DE2906296A1

公开(公告)日：1980-08-28

申请号：DE2906296

申请日：1979-02-19

Applicant: BASF AG

Inventor： KROPP RUDOLF ,  THOEMEL FRANK DIPL CHEM DR ,  NUERRENBACH AXEL DIPL CHEM DR ,  HOFFMANN WERNER DIPL CHEM DR ,  WENISCH FRANZ DIPL CHEM DR ,  FUCHS HARTWIG

IPC: C07C45/00 ,  C07C45/69 ,  C07C49/517 ,  C07C67/00 ,  C07D307/20 ,  C07D309/12 ,  C07D311/74 ,  C07D311/94

Abstract: The preparation of bicyclic enol-ethers (I) (I) (where n is from 3 to 12, and R1, R2 and R3 may be H or C1-C4-alkyl) by free radical adduct formation of CHR1 =CR2-CHR3-O-R4 (III)(where R4 is tert.-butyl, tetrahydrofuran-2-yl or tetrahydropyran-2-yl) with a cyclic ketone (IV) (IV) followed by acid-catalyzed cyclization, and novel compounds II (II) The compounds (I) and (II) are intermediates for the synthesis of musk-like fragrances.

公开(公告)号：DE3202100A1

公开(公告)日：1983-08-04

申请号：DE3202100

申请日：1982-01-23

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DIPL CHE ,  NUERRENBACH AXEL DIPL CHEM DR

IPC: C07C63/66 ,  C07D257/06 ,  C07C103/78 ,  A61K31/165

Abstract: Phenylethylene derivatives of the formula (I) where R1, R2, R3, R4, R5 and A have the meanings given in the description, and their preparation. The novel compounds are useful for combating disorders.

公开(公告)号：DE2843884A1

公开(公告)日：1980-04-24

申请号：DE2843884

申请日：1978-10-07

Applicant: BASF AG

Inventor： SCHMIEDER KLAUS DIPL CHEM DR ,  PAUST JOACHIM DIPL CHEM DR ,  NUERRENBACH AXEL DIPL CHEM DR

IPC: A61K31/07 ,  A61K31/23 ,  A61K31/275 ,  A61P35/00 ,  C07C67/00 ,  C07C253/00 ,  C07C255/31 ,  C07C403/00

公开(公告)号：DE2843811A1

公开(公告)日：1980-04-24

申请号：DE2843811

申请日：1978-10-07

Applicant: BASF AG

Inventor： PAUST JOACHIM DIPL CHEM DR ,  NUERRENBACH AXEL DIPL CHEM DR

IPC: A61K31/195 ,  A61K31/07 ,  A61K31/16 ,  A61K31/165 ,  A61K31/20 ,  A61P17/00 ,  A61P35/00 ,  C07C67/00 ,  C07C401/00 ,  C07C403/00 ,  C07C403/20 ,  C07C175/00

公开(公告)号：DE3322995A1

公开(公告)日：1983-12-29

申请号：DE3322995

申请日：1983-06-25

Applicant: BASF AG

Inventor： VOGEL FRIEDRICH DIPL CHEM DR ,  PAUST JOACHIM DIPL CHEM DR ,  NUERRENBACH AXEL DIPL CHEM DR

IPC: C07D311/72 ,  C07F3/02 ,  C07F9/143 ,  C07F9/54 ,  C07F9/40

Abstract: Compounds of the general formula I in which R denotes H, an alkyl radical, arylalkyl radical or an aliphatic acyl radical, preferably a benzyl group or acetyl group, and Y represents OH and X represents H (Ia) or else X and Y together represent a further bond between the C atoms carrying X and Y (Ib) and the dashed line may denote an additional bond, in particular [2R,1'Z,3'E,7'E]-6-benzyloxy-2,5,7,8-tetramethyl-2-(4',8',12'- trimethyltrideca-1',3',7'-trien-1'-yl)chroman and 6-benzyloxy-2,5,7,8- tetramethyl-2-(1'-hydroxy-4',8',12'-trimethyltrideca-3',7'-dien-1-yl)- chroman, and compounds of the general formula II in which Z represents one of the groups ClMg-; BrMg- (IIa); CL ; BR - (IIb> in which R represents alkyl having 1 to 4 C atoms, in particular (3,7,11-trimethyltrideca-2,6,10-trien-1-yl)triphenylphosphonium chloride and dimethyl (3,7,11-trimethyltrideca-2,6,10-trien-1-yl)- phosphite. The invention furthermore relates to a process for the preparation of (2R,4'RS,8'RS)- alpha -tocopherol or (all-rac)- alpha -tocopherol, starting from the compounds of the formula II and via the compounds of the formula I.

公开(公告)号：DE3119384A1

公开(公告)日：1982-12-02

申请号：DE3119384

申请日：1981-05-15

Applicant: BASF AG

Inventor： LECHTKEN PETER DIPL CHEM DR ,  NUERRENBACH AXEL DIPL CHEM DR ,  SCHOLE JUERGEN PROF

IPC: A23K1/16 ,  A23K1/18 ,  C07D215/58 ,  C07D215/60 ,  A23K1/175 ,  A61K31/47

Abstract: Animal feeds and drinks containing small amounts of compounds of the formula Ia or Ib Ia Ib where R1 is hydrogen, low molecular weight alkyl or alkoxy, or halogen, R2 is hydrogen or low molecular weight alkyl and R3 and R4 are hydrogen or a low molecular weight aliphatic or araliphatic radical. The compounds of the formulae Ia and Ib promote growth without exerting an antibiotic action.

公开(公告)号：DE3030054A1

公开(公告)日：1982-03-25

申请号：DE3030054

申请日：1980-08-08

Applicant: BASF AG

Inventor： SCHMIDT WOLFRAM DIPL CHEM DR ,  PAUST JOACHIM DIPL CHEM DR ,  NUERRENBACH AXEL DIPL CHEM DR

IPC: C07C67/00 ,  C07C215/10 ,  C07C241/00 ,  C07C245/08 ,  C07D475/00 ,  C07D475/14 ,  C09B29/085 ,  C07C107/06

Abstract: A process for the preparation of N-(D)-ribityl-2-phenylazo-4,5-dimethylaniline (I), wherein 1. in the case of pure or virtually pure (D)-ribose (III) (a) the latter is reacted with 3,4-dimethylnitrobenzene (IVa) or 3,4-dimethylaniline (IVb) and with hydrogen in the presence of a hydrogenation catalyst, (b) the resulting solution is reacted, in a conventional manner, with an acid phenyldiazonium salt solution (VI) and (c) the resulting product is isolated by crystallization, in a conventional manner, or 2. in the case of crude ribose, ie. industrial mixtures of (D)-ribose and other sugars (a) the crude ribose is reacted with about equimolar amounts, based on III, of 3,4-dimethylaniline (IVb) and boric acid, (b) the boric acid ester of the Schiff base obtained from III and IVb is allowed to crystallize out and is separated off, (c) this ester is hydrogenated with hydrogen in the presence of a hydrogenation catalyst, (d) the solution is freed from catalyst and reacted, in a conventional manner, with an acid phenyldiazonium salt solution and (e) the resulting product I is isolated by crystallization in a conventional manner.

公开(公告)号：DE3002545A1

公开(公告)日：1981-07-30

申请号：DE3002545

申请日：1980-01-25

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DIPL CHE ,  NUERRENBACH AXEL DIPL CHEM DR

IPC: A61K31/41 ,  A61P17/00 ,  A61P35/00 ,  C07D257/04 ,  C07D257/06 ,  A61K31/07

Abstract: 5-Amino-tetrazole derivatives of retinoic acids and their physiologically tolerated salts, processes for their preparation and pharmaceutical formulations which contain these derivatives and salts and which may, in particular, be used in the treatment of dermatoses.

公开(公告)号：DE3202065A1

公开(公告)日：1983-08-04

申请号：DE3202065

申请日：1982-01-23

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DIPL CHE ,  NUERRENBACH AXEL DIPL CHEM DR

IPC: C07C51/00 ,  C07C63/66 ,  C07C67/00 ,  C07C69/76 ,  C07C233/75 ,  C07D257/06 ,  A61K31/41

Abstract: N-(5-Tetrazolyl)benzamides of the formula (I) in which R and R are hydrogen or a methyl group, R is hydrogen, an alkyl group with one to four carbon atoms, R is a short-chain alkyl group such as the methyl or ethyl group and A is a methylene or ethylene radical which is optionally further substituted with alkyl groups, preferably the methyl group, and the physiologically tolerated salts thereof, process for the preparation thereof and pharmaceutical compositions containing these, especially for the treatment of neoplasms, acne, psoriasis, dermatological disorders and for rheumatic disorders.