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    1.
    发明专利
    未知

    公开(公告)号：DE3834861A1

    公开(公告)日：1990-04-19

    申请号：DE3834861

    申请日：1988-10-13

    Applicant: BASF AG

    Inventor： RENDENBACH BEATRICE DR ,  WEIFENBACH HARALD DR ,  TESCHENDORF HANS-JUERGEN DR ME

    IPC: A61K31/00 ,  A61K31/37 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/16 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  C07D311/16

    Abstract: Arylalkoxycoumarins of the general formula I I where R1 and R2 independently of one another are each hydrogen, lower alkyl, phenyl or halogen, or the two radicals together form an alkylene bridge of 3 to 5 carbon atoms, R3 is lower alkyl or halogen, n is an integer of from 0 to 3, m is an integer of from 0 to 4, R4 is hydrogen or lower alkyl and Ar is a phenyl ring which is monosubstituted to trisubstituted by halogen, C1-C6-alkyl or C1-C6-alkoxy or monosubstituted by nitro, cyano or trifluoromethyl or is a naphthyl ring, with the proviso that m is not 0 when Ar is unsubstituted phenyl, processes for their preparation, and drugs prepared therefrom.

    3.
    发明专利
    未知

    公开(公告)号：DE3869886D1

    公开(公告)日：1992-05-14

    申请号：DE3869886

    申请日：1988-09-09

    Applicant: BASF AG

    Inventor： FRANKE ALBRECHT DR ,  OSTERSEHLT BERND DR ,  SCHLECKER RAINER DR ,  RENDENBACH BEATRICE DR ,  VON PHILIPSBORN GERDA DR

    IPC: A61K31/505 ,  A61K31/55 ,  A61P9/06 ,  C07D471/14 ,  C07D487/14

    Abstract: Tetracyclic quinazoline derivs. of formula (I) and their salts with physiolgically tolerable acids are new. In (I), A = opt. 1-4C alkyl-substd. 2-4C alkylene in which 2 adjacent methylene groups may additionally be linked via an opt. 1-4C alkyl-substd. 2-4C alkylene group so as to form a ring; X = phenyl or naphthyl opt. substd. by halogen, NO2, NH2, 1-4C alkylamino, sulphonylamino, 1-4C acylamino, OH, 1-4C alkoxy, -O(CH2)2-4-NR1R2 (R1,R2 = H or 1-4C alkyl), 104C alkyl or a1-4C alkylsulphonic acid groups, an opt. substd. 5-membered heterocycle; and R=H, halogen, NO2, NH2, 1-4C alkylsulphonic acid group. (I) may be prepd. by reaction of cyclic o-amino-benzamidines of formula (II) with omega-chloro ketones of formula ClCH2CH2CH2-CO-X (III), or by reaction of pyrrolo (1,2-a) (3,1) benzoxazine-5-ones of formula (IV) with diamines of formula H2N-A-NH2 (v). Products in which X in hydroxy-substd. phenyl or naphthyl may be etherified by reaction with amino aminoalkyl halides halogen -(CH2)2-4-NR1R2.

    5.
    发明专利
    未知

    公开(公告)号：DE3834860A1

    公开(公告)日：1990-04-19

    申请号：DE3834860

    申请日：1988-10-13

    Applicant: BASF AG

    Inventor： FRICKEL FRITZ-FRIEDER DR ,  KUEKENHOEHNER THOMAS DR ,  RENDENBACH BEATRICE DR ,  WEIFENBACH HARALD DR ,  TESCHENDORF HANS-JUERGEN DR ME

    IPC: A61K31/335 ,  A61K31/35 ,  A61K31/40 ,  A61K31/41 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/47 ,  A61P25/00 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D419/12

    Abstract: Heterocyclically substituted alkoxycoumarins of the formula in which R and R are, independently of one another, hydrogen, C1- to C5-alkyl, trifluoromethyl, phenyl, halogen or together are a C3- to C5-alkylene chain; furthermore R is C1- to C5-alkyl or halogen; n is an integer from 0 to 3; R is hydrogen or C1- to C4-alkyl and Het is one of the following heterocycles: with the following meanings for the symbols used: X is oxygen or sulphur; R is optionally C1-C4-alkoxy-substituted C1-C10-alkyl, 5-6-membered oxacycloalkyl, C3-C7-cycloalkyl, benzyl, an optionally halogen- or NO2-substituted phenyl radical, a pyridine ring, C1-C5-alkoxycarbonyl, perfluoro-C1-C2-alkyl; R is C1-C5-alkyl, C1-C5-alkoxy; R is C1-C5-alkyl, an optionally halogen-substituted benzyl radical, halogen; m is 0 to 2; R is C1-C5-alkyl, C3-C6-cycloalkyl, benzyl, phenyl; R is hydrogen, C1-C4-alkyl; R is C1-C5-alkyl, C3-C6-cycloalkyl; R is C1-C5-alkyl; R is hydrogen, C1-C5-alkyl, C3-C6-cycloalkyl; R is C1-C5-alkyl, halogen, p = 0 to 2; R is C1-C5-alkyl, q = 0 or 1; R , R are hydrogen, C1-C5-alkyl, benzyl; R is hydrogen, C1-C5-alkyl; R is C1-C5-alkyl with the proviso that R is not phenyl when X is oxygen, R is methyl and R to R are hydrogen, method for their preparation and medicaments prepared therefrom.

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