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    1.
    发明专利
    未知

    公开(公告)号：DE4216942A1

    公开(公告)日：1993-11-25

    申请号：DE4216942

    申请日：1992-05-22

    Applicant: BASF AG

    Inventor： HELLENDAHL BEATE DR ,  SCHLECKER RAINER DR ,  ROEHL FRANZ DR ,  ZIPPLIES MATTHIAS DR ,  RASCHACK MANFRED DR ,  HAFNER MATTHIAS DR

    IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P31/04 ,  C07D217/04 ,  C07D217/06

    Abstract: Medicament for oral administration which contains as active substance per individual dose, besides the customary galenic auxiliaries, 10 to 1000 mg of a compound of general formula (I) or (II) in which W is a carbonyl group or a single bond, R is a hydrogen atom or a group of the general formula R CO in which R is a lower alkyl, lower alkoxy, mono lower alkylamino or di lower alkylamino group, R is an alkyl residue with 3 to 20 carbon atoms which may be branched or unbranched and contain 1 to 3 double bonds, a saturated cycle of 3 to 7 carbon atoms integrated into the chain or as substituent, or may be substituted by one or more aromatic rings or contain an oxygen or sulphur atom, as a racemate and as isolated enantiomers; or the addition salt thereof with a physiologically acceptable acid, and the active substances themselves insofar as they are novel.

    2.
    发明专利
    未知

    公开(公告)号：DE3869273D1

    公开(公告)日：1992-04-23

    申请号：DE3869273

    申请日：1988-08-06

    Applicant: BASF AG

    Inventor： SCHLECKER RAINER DR ,  RASCHACK MANFRED DR ,  GRIES JOSEF DR

    IPC: A61K31/34 ,  A61K31/343 ,  A61K31/40 ,  A61K31/44 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  C07D307/86 ,  C07D405/06 ,  C07D405/12

    Abstract: Benzofuram derivs.of formula (I) are new: R = R' = H or R + R' = a bond; R1 and R2 = H, 1-4C alkyl or phenyl(1-4C)alkyl; Ar = phenyl with 0.3 substits. selected from benzyloxy, F, Cl, Br, OH, 1-6C alkoxy, NH2, mono- or or di(1-4C alkyl)amino, 1-4C acylamino, NO2, CH2OH and 1-4C alkyl or two adjacent substits. are linked to form CH=CH-NH; R4 and R5 = H, 1-4C alkyl or phenyl(1-4C)alkyl, where the phenyl gp. is opt. mono- or disubstd. by F, Cl, Br, 1-4C alkoxy, NH2, mono-or di(1-4C alkyl)amino or NO2, or R4 + R5 = a 3- to 6-membered chain opt. contg. an O or N atom and opt. fused with a benzene ring opt. substd. by F, Ce, Br, 1-4C alkoxy, NH2, mono-or di(1-4C alkyl)amino or NO2; X = COCH=CH, COCH2CH2 or CH(OH)CH2CH2; n = 2 or 3; provided that when R1 = R2 = Me, then R4 = H or alkyl and R5 = opt. substd. phenylakyl or R4+R5 = a 3- to -6 membered chain (opt. contg. O or N) fused with an opt. substd. benzene ring.

    3.
    发明专利
    未知

    公开(公告)号：DE4019782A1

    公开(公告)日：1992-01-02

    申请号：DE4019782

    申请日：1990-06-21

    Applicant: BASF AG

    Inventor： SCHLECKER RAINER DR ,  HOFMANN HANS PETER DR ,  SZABO LASZLO DR

    IPC: A61K31/135 ,  A61K31/445 ,  A61P25/00 ,  C07C211/41 ,  C07C215/64 ,  C07C217/54 ,  C07C217/74 ,  C07C317/32 ,  C07C323/31 ,  C07D211/14

    Abstract: 9-Amino-2-phenylbicyclo-[3.3.1]nonanes and 9-amino-2-phenylbicyclo[3.3.1]non-2-enes of the formula I I where R1 and R2 are identical or different and each is hydrogen, halogen, alkyl, alkoxy, dialkylamino, trifluoromethyl, hydroxyl, alkylthio, alkylsulfonyl or nitro, R3 and R4 are identical or different and each is hydrogen, alkyl or 1 to 5 or alkenyl or alkynyl of 2 to 5 carbon atoms, or benzyl, it also being possible for R3 and R4 together to form a saturated chain which contains from three to seven carbon atoms and can be substituted by phenyl, and where is a single or double bond, are used for producing drugs which act, in particular, on the central nervous system.

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