公开(公告)号：DE2941597A1

公开(公告)日：1981-04-23

申请号：DE2941597

申请日：1979-10-13

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DIPL CHE ,  FRANKE ALBRECHT DIPL CHEM DR ,  PHILIPSBORN GERDA VON DR MED ,  MUELLER CLAUS D DR MED ,  LENKE DIETER PROF DR

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/454 ,  A61K31/47 ,  A61P9/00 ,  A61P9/06 ,  C07C271/22 ,  C07D207/34 ,  C07D207/36 ,  C07D209/42 ,  C07D401/12 ,  C07D401/14

Abstract: Substituted piperidinoalkyl ethers of 4,5-dialkyl-3-hydroxy-pyrrole-2-carboxylic acid esters and their physiologically tolerated addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.

公开(公告)号：DE3732094A1

公开(公告)日：1989-04-06

申请号：DE3732094

申请日：1987-09-24

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  BINNIG FRITZ DR ,  PHILIPSBORN GERDA VON DR MED

IPC: A61K31/435 ,  A61K31/44 ,  A61P9/06 ,  C07D471/08

Abstract: Bispidine derivatives of the formula I I where R, R1 and R3 are identical or different and are each H, C1-C4-alkyl, halogen or C1-C4-alkoxy, when Y is R2 is C1-C4-alkyl, halogen, -CN, C1-C4-alkoxy, -NHSO2CH3, -CF3, NH-acetyl or -NR4R5 where R4 and R5 are each C1-C4-alkyl, when Y is R2 is C1-C4-alkyl, halogen, -CN1C1-C4-alkoxy, -NHSO2CH3, -CF3, NH-acetyl or -NR9R10 where R9 is C1-C4-alkyl and R10 is H or C1-C4-alkyl, and when X is not CH2 R2 may also be NO2 or NH2, X is -CH2-, -C(O)- or -C(R6)OR7- (where R6 is H or C1-C4-alkyl and R7 is H, C1-C4-alkyl or where R8 is H, C1-C4-alkyl, halogen or C1 -C4-alkoxy), Y is -C(O) or -CONH- and Z is C1-C4-alkylene which may be olefinically unsaturated and/or branched, and their physiologically tolerated salts, and drugs containing these compounds as active compounds are described.

公开(公告)号：DE2734882A1

公开(公告)日：1979-02-22

申请号：DE2734882

申请日：1977-08-03

Applicant: BASF AG

Inventor： HAGEN HELMUT DIPL ING DR ,  LENKE DIETER PROF DR ,  PHILIPSBORN GERDA VON DR MED

IPC: A61K31/425 ,  A61K31/505 ,  C07D275/04 ,  C07D417/10

Abstract: 3-[4-(1,3-Diazacyclo-2-yl)]-1,2-benzisothiazoles, their addition salts with acids, their manufacture, and pharmaceutical formulations which contain these compounds as active ingredients and which may be used for the pharmacotherapy of cardiac arrhythmias.

公开(公告)号：DE4036782A1

公开(公告)日：1992-05-21

申请号：DE4036782

申请日：1990-11-17

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  PHILIPSBORN GERDA VON DR MED ,  SCHULT SABINE DR ,  KIRCHENGAST MICHAEL DR

IPC: A61K31/165 ,  A61K31/00 ,  A61K31/16 ,  A61K31/167 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4453 ,  A61P9/00 ,  A61P9/06 ,  C07C233/29 ,  C07C235/38 ,  C07D295/08 ,  C07D295/088 ,  C07D295/092

Abstract: Substituted anilides of the formula I I (where R1 is C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, halogen, cyano, nitro, C2-C4-alkenyl, C2-C4-alkynyl; X is methylene, ethylene, vinylene; R2 and R3 are each C1-C4-alkyl, C3-C6-cycloalkyl or together are tetra- or pentamethylene; R4 is C1-C4-alkyl, methoxy; n is 2, 3 or 4), and the physiologically tolerated acid addition salts thereof, the pharmaceutical use thereof, drugs produced therefrom and the use thereof for treating cardiac arrhythmias and/or for lowering the heart rate, are described.

公开(公告)号：DE3825559A1

公开(公告)日：1990-02-01

申请号：DE3825559

申请日：1988-07-28

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  RASCHACK MANFRED DR ,  PHILIPSBORN GERDA VON DR MED

IPC: A61K31/135 ,  A61K31/13 ,  A61K31/395 ,  A61K31/40 ,  A61K31/445 ,  A61P9/06 ,  C07C217/22 ,  C07D295/08 ,  C07D295/092

Abstract: p-Hydroxyphenone derivatives of the general formula I … … in which R , R and R are identical or different and are methyl, chlorine, bromine and hydrogen, where R , R and R are not all H, R and R are identical or different and are H, C1-C4-alkyl or OR , where R and R are not both H, X is a -CH=CH-, -CH2CH2- and -CH2-bridge, Y is a straight-chain or branched, saturated or unsaturated C1-C4-bridge and Z is the radical NR R , where R and R are, independently of one another, hydrogen or C1-C4-alkyl, or Z is a 5- or 6-membered ring with a nitrogen atom in position 1 and, where appropriate, additionally a second N or an O or S atom, where the second N atom is substituted by R , the physiologically tolerated salts thereof, and medicaments prepared therefrom and the use thereof as Vaughan-Williams Class III antiarrhythmic.

公开(公告)号：DE2711655A1

公开(公告)日：1978-09-21

申请号：DE2711655

申请日：1977-03-17

Applicant: BASF AG

Inventor： BOELL WLATER DIPL CHEM DR ,  LENKE DIETER PROF DR MED ,  PHILIPSBORN GERDA VON DR MED

IPC: A61C8/00 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/455 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  C07D213/127 ,  C07D213/65 ,  C07D213/66 ,  C07D213/67 ,  C07D213/79 ,  C07D213/80 ,  C07D221/04 ,  C07D263/32 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/056

Abstract: New pyridinyl aminoalkyl ethers, their N-oxides and their physiologically acceptable addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.

公开(公告)号：DE3725273A1

公开(公告)日：1989-02-09

申请号：DE3725273

申请日：1987-07-30

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  SCHLECKER RAINER DR ,  GRIES JOSEF DR MED ,  PHILIPSBORN GERDA VON DR MED ,  UNGER LILIANE DR

IPC: A61K31/135 ,  A61P9/06 ,  A61P25/02

Abstract: The agents are prepared as described and used for certain groups of patients.

公开(公告)号：DE2950064A1

公开(公告)日：1981-06-19

申请号：DE2950064

申请日：1979-12-13

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DIPL CHE ,  PHILIPSBORN GERDA VON DR MED ,  MUELLER CLAUS D DR MED ,  LENKE DIETER PROF DR

IPC: A61K31/4433 ,  A61K31/445 ,  A61P9/06 ,  C07D333/38 ,  C07D409/12 ,  A61K31/38

Abstract: Substituted piperidino-alkyl ethers of 3-hydroxy-thiophene-2-carboxylic acid esters and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and which may be used in the treatment of cardiac arrhythmias.

公开(公告)号：DE2841074A1

公开(公告)日：1980-04-03

申请号：DE2841074

申请日：1978-09-21

Applicant: BASF AG

Inventor： ALBRECHT HANS PETER DIPL CHEM ,  PHILIPSBORN GERDA VON DR MED ,  SIEBENEICK HANS ULRICH DIPL CH ,  RASCHACK MANFRED DR

IPC: A61K31/704 ,  A61P9/04 ,  C07J19/00 ,  C07J53/00 ,  A61K31/705

Abstract: 4,5-methano-bufadienolide-rhamnosides of the formula I I where R1 is hydrogen or alkyl or acyl of 1 to 4 carbon atoms, R2 and R3 are identical or different and each is hydrogen or alkyl or acyl of 1 to 4 carbon atoms, or both together are where R4 and R5 are identical or different and each is hydrogen or alkyl or alkoxy of 1 or 2 carbon atoms. The novel compounds may be used for counteracting cardiac insufficiency.

公开(公告)号：DE3825561A1

公开(公告)日：1990-02-01

申请号：DE3825561

申请日：1988-07-28

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  PHILIPSBORN GERDA VON DR MED

IPC: C07D209/08 ,  A61K31/135 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61P9/06 ,  C07C217/22 ,  C07D207/32 ,  C07D207/323 ,  C07D207/333 ,  C07D209/12 ,  C07D231/12 ,  C07D295/08 ,  C07D295/092 ,  C07D333/22

Abstract: Abstract of the disclosure: p-hydroxy phenone derivatives of the formula I I where X is where R1=F, Cl, Br or trifluoromethyl or a heteroaryl of the structure +TR with R2=C1-C4-alkyl, Y is a bridging member of the formula -CH=CH-, -CH2CH2- or -CH2-, is one of the numbers 2, 3 or 4 and is an amino group of the formula -NR2R3 or N-pyrrolidyl or N-piperidyl, where R2 and R3 are, independently of one another, C1-C4-alkyl, as well as the physiologically tolerated salts thereof, are used for preparing antiarrhythmic drugs.