公开(公告)号：DK0714447T3

公开(公告)日：1998-10-07

申请号：DK94925459

申请日：1994-08-17

Applicant: BASF AG

Inventor： LADNER WOLFGANG ,  RETTENMAIER HANSJOERG ,  ZIPPERER BERNHARD ,  HANSEN HANSPETER

IPC: C12P7/52 ,  C07C51/09 ,  C07C53/19 ,  C12P7/40 ,  C12P41/00

Abstract: PCT No. PCT/EP94/02738 Sec. 371 Date Feb. 15, 1996 Sec. 102(e) Date Feb. 15, 1996 PCT Filed Aug. 17, 1994 PCT Pub. No. WO95/06130 PCT Pub. Date Mar. 2, 1995A process for the preparation of (L)-2-chloropropionic acid and its alkali metal, alkaline earth metal or ammonium salts which comprises hydrolyzing isobutyl L-chloropropionate at a pH of from 4 to 8 in the presence of a lipase from Pseudomonas spec. DSM 8246 and isolating the optically active reaction product from the reaction mixture either directly or after conversion of the salt into the acid in a conventional way, or further reacting it in situ. The optically active products are important intermediates for preparing crop protection agents.\!

公开(公告)号：CA2110497C

公开(公告)日：2005-04-19

申请号：CA2110497

申请日：1992-06-23

Applicant: BASF AG

Inventor： BRAATZ REINHARD ,  KURTH ROLAND ,  MENKEL-CONEN ELKE ,  RETTENMAIER HANSJOERG ,  FRIEDRICH THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K38/46 ,  A61K38/00 ,  A61P1/00 ,  A61P1/14 ,  C12N1/20 ,  C12N9/20 ,  C12R1/38 ,  G01N33/573

Abstract: Described is the use of a bacterial lipase from Chromobacter viscosum, Pseudomonas cepacia IAM 1057, Pseudomonas fluorescens and Pseudomonas DSM 6535 which shows a positive immunological cross-section to antibodies of the lipase from Pseudomonas spec. DSM 6483. The lipase from Pseudomonas spec. DSM 6535 is used to produce drugs for use in therapy of maldigestion. The lipase is formed from the species Psedomonas spec. DSM 6483 and/or Pseudonomas cepacia IAM 1057.

公开(公告)号：AT175117T

公开(公告)日：1999-01-15

申请号：AT92912628

申请日：1992-06-23

Applicant: BASF AG

Inventor： BRAATZ REINHARD ,  KURTH ROLAND ,  MENKEL-CONEN ELKE ,  RETTENMAIER HANSJOERG ,  FRIEDRICH THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K38/46 ,  A61K38/00 ,  A61P1/00 ,  A61P1/14 ,  C12N1/20 ,  C12N9/20 ,  C12R1/38 ,  G01N33/573

Abstract: PCT No. PCT/EP92/01412 Sec. 371 Date Dec. 28, 1993 Sec. 102(e) Date Dec. 28, 1993 PCT Filed Jun. 23, 1992 PCT Pub. No. WO93/00924 PCT Pub. Date Jan. 21, 1993.The use of bacterial lipases which show an immunological cross-reaction with the antibodies to the lipase produced by the microorganism Pseudomonas spec. DSM 6483 and/or Pseudomonas cepacia IAM 1057 for producing drugs for the therapy of maldigestion is described.

公开(公告)号：AT166393T

公开(公告)日：1998-06-15

申请号：AT94925459

申请日：1994-08-17

Applicant: BASF AG

Inventor： LADNER WOLFGANG ,  RETTENMAIER HANSJOERG ,  ZIPPERER BERNHARD ,  HANSEN HANSPETER

IPC: C12P7/52 ,  C07C51/09 ,  C07C53/19 ,  C12P7/40 ,  C12P41/00

Abstract: PCT No. PCT/EP94/02738 Sec. 371 Date Feb. 15, 1996 Sec. 102(e) Date Feb. 15, 1996 PCT Filed Aug. 17, 1994 PCT Pub. No. WO95/06130 PCT Pub. Date Mar. 2, 1995A process for the preparation of (L)-2-chloropropionic acid and its alkali metal, alkaline earth metal or ammonium salts which comprises hydrolyzing isobutyl L-chloropropionate at a pH of from 4 to 8 in the presence of a lipase from Pseudomonas spec. DSM 8246 and isolating the optically active reaction product from the reaction mixture either directly or after conversion of the salt into the acid in a conventional way, or further reacting it in situ. The optically active products are important intermediates for preparing crop protection agents.\!

公开(公告)号：CA2110497A1

公开(公告)日：1993-01-21

申请号：CA2110497

申请日：1992-06-23

Applicant: BASF AG

Inventor： BRAATZ REINHARD ,  KURTH ROLAND ,  MENKEL-CONEN ELKE ,  RETTENMAIER HANSJOERG ,  FRIEDRICH THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K38/46 ,  A61K38/00 ,  A61P1/00 ,  A61P1/14 ,  C12N1/20 ,  C12N9/20 ,  C12R1/38 ,  G01N33/573

Abstract: 2110497 9300924 PCTABS00019 Described is the use of a bacterial lipase which shows a positive immunological cross-reaction to antibodies of the lipase to produce drugs for use in the therapy of digestive disorders. The lipase is formed from the species Psedomonas spec. DSM 6483 and/or Pseudomonas cepacia IAM 1057.

公开(公告)号：DK0592478T3

公开(公告)日：1999-08-30

申请号：DK92912628

申请日：1992-06-23

Applicant: BASF AG

Inventor： BRAATZ REINHARD ,  KURTH ROLAND ,  MENKEL-CONEN ELKE ,  RETTENMAIER HANSJOERG ,  FRIEDRICH THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K38/46 ,  A61K38/00 ,  A61P1/00 ,  A61P1/14 ,  C12N1/20 ,  C12N9/20 ,  C12R1/38 ,  G01N33/573 ,  A61K37/54

Abstract: PCT No. PCT/EP92/01412 Sec. 371 Date Dec. 28, 1993 Sec. 102(e) Date Dec. 28, 1993 PCT Filed Jun. 23, 1992 PCT Pub. No. WO93/00924 PCT Pub. Date Jan. 21, 1993.The use of bacterial lipases which show an immunological cross-reaction with the antibodies to the lipase produced by the microorganism Pseudomonas spec. DSM 6483 and/or Pseudomonas cepacia IAM 1057 for producing drugs for the therapy of maldigestion is described.

公开(公告)号：ES2125901T3

公开(公告)日：1999-03-16

申请号：ES92912628

申请日：1992-06-23

Applicant: BASF AG

Inventor： BRAATZ REINHARD ,  KURTH ROLAND ,  MENKEL-CONEN ELKE ,  RETTENMAIER HANSJOERG ,  FRIEDRICH THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K38/46 ,  A61K38/00 ,  A61P1/00 ,  A61P1/14 ,  C12N1/20 ,  C12N9/20 ,  C12R1/38 ,  G01N33/573

Abstract: PCT No. PCT/EP92/01412 Sec. 371 Date Dec. 28, 1993 Sec. 102(e) Date Dec. 28, 1993 PCT Filed Jun. 23, 1992 PCT Pub. No. WO93/00924 PCT Pub. Date Jan. 21, 1993.The use of bacterial lipases which show an immunological cross-reaction with the antibodies to the lipase produced by the microorganism Pseudomonas spec. DSM 6483 and/or Pseudomonas cepacia IAM 1057 for producing drugs for the therapy of maldigestion is described.

公开(公告)号：DE59209604D1

公开(公告)日：1999-02-11

申请号：DE59209604

申请日：1992-06-23

Applicant: BASF AG

Inventor： BRAATZ REINHARD ,  KURTH ROLAND ,  MENKEL-CONEN ELKE ,  RETTENMAIER HANSJOERG ,  FRIEDRICH THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K38/46 ,  A61K38/00 ,  A61P1/00 ,  A61P1/14 ,  C12N1/20 ,  C12N9/20 ,  C12R1/38 ,  G01N33/573

Abstract: PCT No. PCT/EP92/01412 Sec. 371 Date Dec. 28, 1993 Sec. 102(e) Date Dec. 28, 1993 PCT Filed Jun. 23, 1992 PCT Pub. No. WO93/00924 PCT Pub. Date Jan. 21, 1993.The use of bacterial lipases which show an immunological cross-reaction with the antibodies to the lipase produced by the microorganism Pseudomonas spec. DSM 6483 and/or Pseudomonas cepacia IAM 1057 for producing drugs for the therapy of maldigestion is described.

公开(公告)号：DE59406040D1

公开(公告)日：1998-06-25

申请号：DE59406040

申请日：1994-08-17

Applicant: BASF AG

Inventor： LADNER WOLFGANG ,  RETTENMAIER HANSJOERG ,  ZIPPERER BERNHARD ,  HANSEN HANSPETER

IPC: C12P7/52 ,  C07C51/09 ,  C07C53/19 ,  C12P7/40 ,  C12P41/00

Abstract: PCT No. PCT/EP94/02738 Sec. 371 Date Feb. 15, 1996 Sec. 102(e) Date Feb. 15, 1996 PCT Filed Aug. 17, 1994 PCT Pub. No. WO95/06130 PCT Pub. Date Mar. 2, 1995A process for the preparation of (L)-2-chloropropionic acid and its alkali metal, alkaline earth metal or ammonium salts which comprises hydrolyzing isobutyl L-chloropropionate at a pH of from 4 to 8 in the presence of a lipase from Pseudomonas spec. DSM 8246 and isolating the optically active reaction product from the reaction mixture either directly or after conversion of the salt into the acid in a conventional way, or further reacting it in situ. The optically active products are important intermediates for preparing crop protection agents.\!

公开(公告)号：MX9203832A

公开(公告)日：1993-01-01

申请号：MX9203832

申请日：1992-06-30

Applicant: BASF AG

Inventor： BRAATZ REIHARD ,  KURTH ROLAND ,  MANKEL-CONEN ELKE ,  RETTENMAIER HANSJOERG ,  FRIEDRICH THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K38/46 ,  A61K38/00 ,  A61P1/00 ,  A61P1/14 ,  C12N1/20 ,  C12N9/20 ,  C12R1/38 ,  G01N33/573 ,  A61K39/104

Abstract: PCT No. PCT/EP92/01412 Sec. 371 Date Dec. 28, 1993 Sec. 102(e) Date Dec. 28, 1993 PCT Filed Jun. 23, 1992 PCT Pub. No. WO93/00924 PCT Pub. Date Jan. 21, 1993.The use of bacterial lipases which show an immunological cross-reaction with the antibodies to the lipase produced by the microorganism Pseudomonas spec. DSM 6483 and/or Pseudomonas cepacia IAM 1057 for producing drugs for the therapy of maldigestion is described.