公开(公告)号：DE10009000A1

公开(公告)日：2001-08-30

申请号：DE10009000

申请日：2000-02-25

Applicant: BASF AG

Inventor： HENKELMANN JOCHEM ,  ARNDT JAN-DIRK ,  KNOCHEL PAUL ,  RODRIGUEZ ALAIN-LOUIS ,  DOHLE WOLFGANG ,  KORADIN CHRISTOPHER

IPC: C07B61/00 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D209/40 ,  C07D409/04 ,  C07D417/04 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D209/10 ,  C07D405/04

Abstract: The present application describes a process for preparing compounds of the indole type of the formulain which A is a hydrocarbon radical which, together with the carbons to which it is attached, forms a substituted or unsubstituted mono- or polycyclic aromatic system which may contain one or more heteroatoms from the group consisting of N, O and S, andR1, R2 independently of one another are H, a saturated, linear or branched aliphatic C1-C20-hydrocarbon radical, an unsaturated, linear or branched aliphatic C2-C20-hydrocarbon radical, a saturated or unsaturated, unsubstituted or alkyl-substituted cycloaliphatic C3-C20-hydrocarbon radical or an aromatic C5-C20-hydrocarbon radical, where these radicals may contain in their molecular skeleton one or more heteroatoms from the group consisting of the halogens, N, P, O, S, Si, Sn and B and may be substituted or unsubstituted, by cyclization of alkynylaminoaromatics of the formulain which R1 and R2 are as defined in formula (I) and R1, R2 or A may be attached to an organic or inorganic carrier, which comprises carrying out the reaction in a polar aprotic ion-solvating solvent in the presence of a suitable compound of Na, K, Rb or Cs.Using this process, it is possible to prepare substituted indoles in a simple manner and in high yields.